AutismKB 2.0

Annotation Detail for SLC22A3


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Basic Information Top
Gene Symbol:SLC22A3 ( EMT,EMTH,OCT3 )
Gene Full Name: solute carrier family 22 (extraneuronal monoamine transporter), member 3
Band: 6q25.3
Quick LinksEntrez ID:6581; OMIM: 604842; Uniprot ID:S22A3_HUMAN; ENSEMBL ID: ENSG00000146477; HGNC ID: 10967
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult62 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor7 / 9635972
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal85 / 336030725
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer25 / 102680243
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain18 / 110098916
cervix0 / 481710 
connective tissue1 / 1492556
ear7 / 16212431
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver20 / 20774396
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate31 / 189345163
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach4 / 9661941
testis7 / 33044221
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus3 / 23287812
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205421_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.3
Adipocyte7.5
AdrenalCortex11.05
Adrenalgland7.35
Amygdala7.5
Appendix13
AtrioventricularNode10.4
BDCA4+_DentriticCells7.5
Bonemarrow9.15
BronchialEpithelialCells7.3
CD105+_Endothelial7.65
CD14+_Monocytes8.45
CD19+_BCells(neg._sel.)7.85
CD33+_Myeloid9.2
CD34+8.9
CD4+_Tcells7.55
CD56+_NKCells8.3
CD71+_EarlyErythroid7.55
CD8+_Tcells6.8
CardiacMyocytes16.4
Caudatenucleus7
Cerebellum6.45
CerebellumPeduncles9.9
CiliaryGanglion8.2
CingulateCortex8.35
Colorectaladenocarcinoma7.7
DorsalRootGanglion7.95
FetalThyroid8.05
Fetalbrain7.35
Fetalliver7.35
Fetallung5.95
GlobusPallidus6.55
Heart14.9
Hypothalamus7.85
Kidney7.45
Leukemia_chronicMyelogenousK-5626.9
Leukemia_promyelocytic-HL-606.85
Leukemialymphoblastic(MOLT-4)5.8
Liver15.25
Lung8.55
Lymphnode6.75
Lymphoma_burkitts(Daudi)10.55
Lymphoma_burkitts(Raji)12.95
MedullaOblongata6.75
OccipitalLobe6.85
OlfactoryBulb6
Ovary6.8
Pancreas6.75
PancreaticIslet8.45
ParietalLobe9.05
Pituitary9
Placenta10.35
Pons8
PrefrontalCortex9.05
Prostate33.15
Salivarygland8.5
SkeletalMuscle14.5
Skin8.25
SmoothMuscle8.8
Spinalcord8.15
SubthalamicNucleus7.6
SuperiorCervicalGanglion13.5
TemporalLobe7.4
Testis6.6
TestisGermCell6.2
TestisIntersitial6.75
TestisLeydigCell8.45
TestisSeminiferousTubule6.65
Thalamus8.2
Thymus5.6
Thyroid9
Tongue9.95
Tonsil7.8
Trachea6.45
TrigeminalGanglion10.95
Uterus12.45
UterusCorpus8.6
WholeBlood8.25
Wholebrain5.9
colon7.85
pineal_day9.32
pineal_night9.26
retina9.3
small_intestine7.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P19733
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.85 ± 0.76
Basal Forebrain3.15 ± 0.61
Basal Part of Pons2.9 ± 0.43
Cerebellar Cortex3.28 ± 0.58
Cerebellar Nuclei4.51 ± 0.71
Claustrum3.36 ± 0.8
Epithalamus3.49 ± 0.97
Frontal Lobe3.77 ± 0.79
Globus Pallidus5.36 ± 0.65
Hypothalamus3.88 ± 0.53
Insula3.82 ± 0.36
Limbic Lobe3.53 ± 0.57
Mesencephalon4.16 ± 0.71
Myelencephalon3.97 ± 0.77
Occipital Lobe3.48 ± 0.69
Parietal Lobe3.82 ± 0.65
Pontine Tegmentum4.04 ± 0.54
Striatum4.83 ± 0.47
Subthalamus3.35 ± 0.22
Temporal Lobe3.84 ± 0.69
Thalamus4.39 ± 0.56
White Matter2.46 ± 0.58
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc22a3CBCerebellum9.45
11.72
Slc22a3CTXCerebral cortex9.61
7.06
Slc22a3HIPHippocampal region5.85
5.94
Slc22a3HPFHippocampal formation5.74
5.48
Slc22a3HYHypothalamus2.32
2.12
Slc22a3LSXLateral septal complex2.66
2.29
Slc22a3MBMidbrain3.59
4.73
Slc22a3MYMedulla5.41
6.27
Slc22a3OLFOlfactory bulb17.09
15.29
Slc22a3PPons5.08
6.91
Slc22a3PALPallidum2.92
2.48
Slc22a3RHPRetrohippocampal region5.53
4.7
Slc22a3sAMYStriatum-like amygdalar nuclei2.61
1.87
Slc22a3STRStriatum11.03
8.46
Slc22a3STRdStriatum dorsal region11.93
8.8
Slc22a3STRvStriatum ventral region16.84
13.55
Slc22a3THThalamus6.45
5.51
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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