AutismKB 2.0

Annotation Detail for TMEM108


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Basic Information Top
Gene Symbol:TMEM108 ( CT124,MGC3040 )
Gene Full Name: transmembrane protein 108
Band: 3q22.1
Quick LinksEntrez ID:66000; OMIM: NA; Uniprot ID:TM108_HUMAN; ENSEMBL ID: ENSG00000144868; HGNC ID: 28451
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus29 / 56401251
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal64 / 336030719
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS21 / 125680167
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain45 / 110098940
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye9 / 21105442
heart2 / 8962622
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung28 / 33697483
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis14 / 33044242
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P71781
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.08 ± 0.47
Basal Forebrain5.85 ± 0.37
Basal Part of Pons5.4 ± 0.41
Cerebellar Cortex6.4 ± 0.18
Cerebellar Nuclei5.36 ± 0.48
Claustrum5.42 ± 0.49
Epithalamus5.99 ± 0.55
Frontal Lobe6.29 ± 0.44
Globus Pallidus5.25 ± 0.24
Hypothalamus5.9 ± 0.82
Insula6.43 ± 0.21
Limbic Lobe6.03 ± 0.68
Mesencephalon5.93 ± 0.59
Myelencephalon5.92 ± 0.84
Occipital Lobe5.34 ± 0.88
Parietal Lobe6.11 ± 0.47
Pontine Tegmentum6.3 ± 0.86
Striatum4.36 ± 0.91
Subthalamus5.09 ± 0.61
Temporal Lobe6.36 ± 0.35
Thalamus6.59 ± 0.61
White Matter3.6 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem108CBCerebellum88.69
100
Tmem108CTXCerebral cortex81.02
71.4
Tmem108HIPHippocampal region86.02
100
Tmem108HPFHippocampal formation80.02
95.51
Tmem108HYHypothalamus44.1
38.96
Tmem108LSXLateral septal complex23.7
19.03
Tmem108MBMidbrain47.76
48.32
Tmem108MYMedulla40.58
51.51
Tmem108OLFOlfactory bulb78.66
79.16
Tmem108PPons42.62
48.55
Tmem108PALPallidum26.48
24.73
Tmem108RHPRetrohippocampal region70.89
68.83
Tmem108sAMYStriatum-like amygdalar nuclei41.74
33.96
Tmem108STRStriatum21.46
17.63
Tmem108STRdStriatum dorsal region17.03
14.27
Tmem108STRvStriatum ventral region23.51
17.84
Tmem108THThalamus71.52
69.46
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018