AutismKB 2.0

Annotation Detail for SIGLEC1


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Basic Information Top
Gene Symbol:SIGLEC1 ( CD169,DKFZp667F058,FLJ00051,FLJ00055,FLJ00073,FLJ00411,FLJ32150,SIGLEC-1,SN,dJ1009E24.1 )
Gene Full Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Band: 20p13
Quick LinksEntrez ID:6614; OMIM: 600751; Uniprot ID:SN_HUMAN; ENSEMBL ID: ENSG00000088827; HGNC ID: 11127
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult36 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma7 / 10688365
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal32 / 33603079
ovarian tumor6 / 7668278
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone3 / 7165541
bone marrow0 / 488010 
brain10 / 11009899
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart2 / 8962622
intestine2 / 2344728
kidney3 / 21177714
larynx0 / 241450 
liver1 / 2077434
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary6 / 10205158
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis0 / 3304420 
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 44673_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.15
Adipocyte7
AdrenalCortex10.7
Adrenalgland6.5
Amygdala7.45
Appendix7.75
AtrioventricularNode5.6
BDCA4+_DentriticCells8
Bonemarrow7.35
BronchialEpithelialCells6.9
CD105+_Endothelial7.15
CD14+_Monocytes7.65
CD19+_BCells(neg._sel.)7.1
CD33+_Myeloid12.1
CD34+8.65
CD4+_Tcells7.3
CD56+_NKCells8.15
CD71+_EarlyErythroid6.55
CD8+_Tcells6.45
CardiacMyocytes9.45
Caudatenucleus6.35
Cerebellum5.75
CerebellumPeduncles9.75
CiliaryGanglion5.3
CingulateCortex7.15
Colorectaladenocarcinoma7.2
DorsalRootGanglion5.65
FetalThyroid6.95
Fetalbrain7.05
Fetalliver6.4
Fetallung5.85
GlobusPallidus5.3
Heart11.25
Hypothalamus7.4
Kidney5.9
Leukemia_chronicMyelogenousK-5626.45
Leukemia_promyelocytic-HL-606.3
Leukemialymphoblastic(MOLT-4)5.75
Liver14.55
Lung17.45
Lymphnode25.75
Lymphoma_burkitts(Daudi)9.15
Lymphoma_burkitts(Raji)10.35
MedullaOblongata6.45
OccipitalLobe6.4
OlfactoryBulb5.6
Ovary5.55
Pancreas5.8
PancreaticIslet8.65
ParietalLobe7.65
Pituitary8.4
Placenta8.9
Pons7.1
PrefrontalCortex8.7
Prostate8.25
Salivarygland5.85
SkeletalMuscle8.5
Skin5.8
SmoothMuscle7.95
Spinalcord7.55
SubthalamicNucleus6.6
SuperiorCervicalGanglion8.5
TemporalLobe6.65
Testis6.1
TestisGermCell6.3
TestisIntersitial6.25
TestisLeydigCell7.05
TestisSeminiferousTubule6
Thalamus7.2
Thymus6.8
Thyroid8.95
Tongue8.45
Tonsil9.05
Trachea6
TrigeminalGanglion7.55
Uterus5.75
UterusCorpus6.35
WholeBlood7.85
Wholebrain6
colon7.15
pineal_day8.66
pineal_night8.2
retina8.775
small_intestine6.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P17481
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.51 ± 1.01
Basal Forebrain2.07 ± 0.23
Basal Part of Pons1.7 ± 0.36
Cerebellar Cortex1.81 ± 0.57
Cerebellar Nuclei2.43 ± 0.71
Claustrum3.02 ± 0.93
Epithalamus1.83 ± 0.75
Frontal Lobe1.88 ± 0.58
Globus Pallidus3.09 ± 0.76
Hypothalamus2.12 ± 0.71
Insula1.89 ± 0.52
Limbic Lobe2.08 ± 0.7
Mesencephalon2.22 ± 0.68
Myelencephalon2.1 ± 0.68
Occipital Lobe2.12 ± 0.65
Parietal Lobe2.09 ± 0.76
Pontine Tegmentum2.15 ± 0.73
Striatum2.38 ± 0.93
Subthalamus2.22 ± 0.67
Temporal Lobe1.96 ± 0.63
Thalamus2.03 ± 0.59
White Matter2.44 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Siglec1CBCerebellum1.11
1.61
Siglec1CTXCerebral cortex0.7
0.8
Siglec1HIPHippocampal region0.57
0.55
Siglec1HPFHippocampal formation0.65
0.6
Siglec1HYHypothalamus0.4
0.38
Siglec1LSXLateral septal complex0.25
0.22
Siglec1MBMidbrain0.74
0.7
Siglec1MYMedulla3.35
4.44
Siglec1OLFOlfactory bulb2.05
2.91
Siglec1PPons0.93
0.78
Siglec1PALPallidum0.23
0.15
Siglec1RHPRetrohippocampal region0.83
0.64
Siglec1sAMYStriatum-like amygdalar nuclei0.94
0.67
Siglec1STRStriatum0.46
0.38
Siglec1STRdStriatum dorsal region0.33
0.26
Siglec1STRvStriatum ventral region0.54
0.46
Siglec1THThalamus0.68
0.56
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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