AutismKB 2.0

Annotation Detail for SNCB


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Basic Information Top
Gene Symbol:SNCB ( - )
Gene Full Name: synuclein, beta
Band: 5q35.2
Quick LinksEntrez ID:6620; OMIM: 602569; Uniprot ID:SYUB_HUMAN; ENSEMBL ID: ENSG00000074317; HGNC ID: 11140
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal84 / 336030724
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain57 / 110098951
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye23 / 211054108
heart1 / 8962611
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207853_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.4
Adipocyte5.4
AdrenalCortex5.6
Adrenalgland4.55
Amygdala149.6
Appendix5.75
AtrioventricularNode4.1
BDCA4+_DentriticCells5.3
Bonemarrow5.3
BronchialEpithelialCells5.3
CD105+_Endothelial5.35
CD14+_Monocytes5.65
CD19+_BCells(neg._sel.)5.7
CD33+_Myeloid6.35
CD34+6
CD4+_Tcells5.65
CD56+_NKCells5.6
CD71+_EarlyErythroid5
CD8+_Tcells4.5
CardiacMyocytes7.35
Caudatenucleus11.2
Cerebellum63.7
CerebellumPeduncles175.1
CiliaryGanglion3.8
CingulateCortex120.4
Colorectaladenocarcinoma5.45
DorsalRootGanglion4.15
FetalThyroid5.2
Fetalbrain20.1
Fetalliver4.75
Fetallung4.15
GlobusPallidus114.6
Heart7.25
Hypothalamus32.2
Kidney4.45
Leukemia_chronicMyelogenousK-5624.85
Leukemia_promyelocytic-HL-604.8
Leukemialymphoblastic(MOLT-4)4.25
Liver7.3
Lung6.05
Lymphnode4.55
Lymphoma_burkitts(Daudi)6.9
Lymphoma_burkitts(Raji)7.7
MedullaOblongata89.45
OccipitalLobe87.85
OlfactoryBulb4.3
Ovary3.6
Pancreas4.3
PancreaticIslet5.85
ParietalLobe94.2
Pituitary6.5
Placenta5.55
Pons87.65
PrefrontalCortex456.65
Prostate6.25
Salivarygland4.25
SkeletalMuscle6.85
Skin4.15
SmoothMuscle6.1
Spinalcord5.85
SubthalamicNucleus170.35
SuperiorCervicalGanglion6.25
TemporalLobe145.35
Testis4.7
TestisGermCell4.4
TestisIntersitial4.55
TestisLeydigCell5.3
TestisSeminiferousTubule4.65
Thalamus80.8
Thymus4.15
Thyroid6.75
Tongue5.45
Tonsil5.2
Trachea4.45
TrigeminalGanglion5.7
Uterus4.35
UterusCorpus4.85
WholeBlood5.7
Wholebrain226.1
colon5.4
pineal_day115.12
pineal_night121.76
retina19.5
small_intestine5.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3_PI416558205
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.88 ± 0.84
Basal Forebrain4.45 ± 0.34
Basal Part of Pons4.59 ± 0.52
Cerebellar Cortex4.47 ± 0.46
Cerebellar Nuclei4.46 ± 0.41
Claustrum5.32 ± 0.8
Epithalamus4.1 ± 0.48
Frontal Lobe4.45 ± 0.52
Globus Pallidus4.87 ± 0.66
Hypothalamus4.4 ± 0.57
Insula4.4 ± 0.42
Limbic Lobe4.56 ± 0.63
Mesencephalon4.58 ± 0.61
Myelencephalon4.61 ± 0.54
Occipital Lobe4.56 ± 0.53
Parietal Lobe4.63 ± 0.59
Pontine Tegmentum4.41 ± 0.64
Striatum4.21 ± 0.7
Subthalamus4.37 ± 0.31
Temporal Lobe4.57 ± 0.5
Thalamus4.65 ± 0.47
White Matter4.88 ± 0.81
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00136614 11 33 43 TKEGVLYVGSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018