AutismKB 2.0

Annotation Detail for FSCN1


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Basic Information Top
Gene Symbol:FSCN1 ( FLJ38511,SNL,p55 )
Gene Full Name: fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
Band: 7p22.1
Quick LinksEntrez ID:6624; OMIM: 602689; Uniprot ID:FSCN1_HUMAN; ENSEMBL ID: ENSG00000075618; HGNC ID: 11148
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body17 / 70761240
blastocyst10 / 62319160
fetus27 / 56401247
neonate3 / 3109796
infant0 / 236200 
juvenile4 / 5555671
adult94 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor6 / 34366174
chondrosarcoma15 / 82823181
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor63 / 263845238
glioma43 / 106883402
head and neck tumor16 / 136302117
kidney tumor15 / 68959217
leukemia4 / 9584241
liver tumor7 / 9635972
lung tumor22 / 103127213
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal142 / 336030742
ovarian tumor4 / 7668252
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS19 / 125680151
prostate cancer5 / 10268048
retinoblastoma10 / 46356215
skin tumor4 / 12494932
soft tissue/muscle tissue tumor26 / 125191207
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood4 / 12347832
bone14 / 71655195
bone marrow3 / 4880161
brain86 / 110098978
cervix6 / 48171124
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue38 / 215722176
esophagus2 / 2020998
eye25 / 211054118
heart5 / 8962655
intestine11 / 23447246
kidney18 / 21177784
larynx2 / 2414582
liver8 / 20774338
lung34 / 336974100
lymph0 / 442700 
lymph node2 / 9161021
mammary gland1 / 1532716
mouth3 / 6705244
muscle16 / 107715148
nerve1 / 1576863
ovary8 / 10205178
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate7 / 18934536
salivary gland8 / 20155396
skin11 / 21057452
spleen3 / 5395255
stomach1 / 9661910
testis21 / 33044263
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus18 / 23287877
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210933_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts588.3
Adipocyte45.1
AdrenalCortex50.7
Adrenalgland43.8
Amygdala546.85
Appendix43.6
AtrioventricularNode37.95
BDCA4+_DentriticCells27.35
Bonemarrow40.2
BronchialEpithelialCells455.5
CD105+_Endothelial79.75
CD14+_Monocytes44.8
CD19+_BCells(neg._sel.)37.95
CD33+_Myeloid51.6
CD34+151.35
CD4+_Tcells25.8
CD56+_NKCells37.1
CD71+_EarlyErythroid35.85
CD8+_Tcells23.55
CardiacMyocytes299.2
Caudatenucleus89.35
Cerebellum35
CerebellumPeduncles49.45
CiliaryGanglion32.35
CingulateCortex67.5
Colorectaladenocarcinoma47.5
DorsalRootGanglion34.75
FetalThyroid44.3
Fetalbrain298.1
Fetalliver39.8
Fetallung35.55
GlobusPallidus51.95
Heart63
Hypothalamus77.95
Kidney33.25
Leukemia_chronicMyelogenousK-562232.15
Leukemia_promyelocytic-HL-6031.75
Leukemialymphoblastic(MOLT-4)23.1
Liver58.75
Lung50.15
Lymphnode45.05
Lymphoma_burkitts(Daudi)49.45
Lymphoma_burkitts(Raji)56.35
MedullaOblongata80.15
OccipitalLobe57
OlfactoryBulb65.55
Ovary28.35
Pancreas34.75
PancreaticIslet38.25
ParietalLobe54.3
Pituitary41.15
Placenta123.5
Pons43.55
PrefrontalCortex113.25
Prostate39.2
Salivarygland31.7
SkeletalMuscle53.7
Skin33.85
SmoothMuscle270.35
Spinalcord52.4
SubthalamicNucleus43.5
SuperiorCervicalGanglion50.95
TemporalLobe40.25
Testis107.15
TestisGermCell40.35
TestisIntersitial36.35
TestisLeydigCell40.65
TestisSeminiferousTubule39.65
Thalamus57.85
Thymus35.1
Thyroid104.1
Tongue48.55
Tonsil41.35
Trachea26.35
TrigeminalGanglion46.4
Uterus36.05
UterusCorpus38.55
WholeBlood35.05
Wholebrain310.55
colon38.3
pineal_day96.94
pineal_night99.7
retina83.875
small_intestine41.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P168532
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.67 ± 0.55
Basal Forebrain4.94 ± 0.28
Basal Part of Pons5.23 ± 0.5
Cerebellar Cortex4.45 ± 0.48
Cerebellar Nuclei5.33 ± 0.35
Claustrum5.96 ± 0.35
Epithalamus3.89 ± 0.76
Frontal Lobe5.05 ± 0.58
Globus Pallidus5.5 ± 0.32
Hypothalamus4.35 ± 0.53
Insula5.02 ± 0.47
Limbic Lobe5.35 ± 0.56
Mesencephalon4.96 ± 0.63
Myelencephalon5.17 ± 0.65
Occipital Lobe5.14 ± 0.56
Parietal Lobe5.23 ± 0.66
Pontine Tegmentum5.23 ± 0.64
Striatum5.57 ± 0.54
Subthalamus4.82 ± 0.36
Temporal Lobe5.3 ± 0.55
Thalamus5.37 ± 0.4
White Matter5.63 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fscn1CBCerebellum41.51
49.57
Fscn1CTXCerebral cortex100
100
Fscn1HIPHippocampal region85.94
100
Fscn1HPFHippocampal formation96.29
100
Fscn1HYHypothalamus57.58
55.15
Fscn1LSXLateral septal complex78.17
75.13
Fscn1MBMidbrain73.38
76.38
Fscn1MYMedulla86.45
94.48
Fscn1OLFOlfactory bulb100
100
Fscn1PPons89.23
92.47
Fscn1PALPallidum77.24
86.04
Fscn1RHPRetrohippocampal region100
100
Fscn1sAMYStriatum-like amygdalar nuclei84.27
78.9
Fscn1STRStriatum100
100
Fscn1STRdStriatum dorsal region100
100
Fscn1STRvStriatum ventral region100
100
Fscn1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FSCN1_HUMAN_0 0 0 0 YWTLTATGGVQSTASSK PRIDE
FSCN1_HUMAN_118 13 118 130 LSCFAQTVSPAEK PRIDE
FSCN1_HUMAN_131 18 131 148 WSVHIAMHPQVNIYSVTR PRIDE
FSCN1_HUMAN_150 35 150 184 RYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQR PRIDE
FSCN1_HUMAN_151 16 151 166 YAHLSARPADEIAVDR PRIDE
FSCN1_HUMAN_151 34 151 184 YAHLSARPADEIAVDRDVPWGVDSLITLAFQDQR PRIDE
FSCN1_HUMAN_158 9 158 166 PADEIAVDR PRIDE
FSCN1_HUMAN_167 18 167 184 DVPWGVDSLITLAFQDQR PRIDE
FSCN1_HUMAN_201 16 201 216 LVARPEPATGYTLEFR PRIDE
FSCN1_HUMAN_22 10 22 31 YLTAEAFGFK PRIDE
FSCN1_HUMAN_229 12 229 240 YLAPSGPSGTLK PRIDE
FSCN1_HUMAN_244 27 244 270 ATKVGKDELFALEQSCAQVVLQAANER PRIDE
FSCN1_HUMAN_247 24 247 270 VGKDELFALEQSCAQVVLQAANER PRIDE
FSCN1_HUMAN_308 22 308 329 THTGKYWTLTATGGVQSTASSK PRIDE
FSCN1_HUMAN_330 11 330 340 NASCYFDIEWR PRIDE
FSCN1_HUMAN_359 20 359 378 NGQLAASVETAGDSELFLMK PRIDE
FSCN1_HUMAN_379 10 379 388 LINRPIIVFR PRIDE
FSCN1_HUMAN_379 19 379 397 LINRPIIVFRGEHGFIGCR PRIDE
FSCN1_HUMAN_408 23 408 430 SSYDVFQLEFNDGAYNIKDSTGK PRIDE
FSCN1_HUMAN_468 11 468 478 YLKGDHAGVLK PRIDE
FSCN1_HUMAN_479 14 479 492 ASAETVDPASLWEY PRIDE
FSCN1_HUMAN_90 10 90 99 FLIVAHDDGR PRIDE
PAp00002762 9 396 404 GEHGFIGCR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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