AutismKB 2.0

Annotation Detail for BNIP2


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Basic Information Top
Gene Symbol:BNIP2 ( BNIP-2,NIP2 )
Gene Full Name: BCL2/adenovirus E1B 19kDa interacting protein 2
Band: 15q22.2
Quick LinksEntrez ID:663; OMIM: 603292; Uniprot ID:BNIP2_HUMAN; ENSEMBL ID: ENSG00000140299; HGNC ID: 1083
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus22 / 56401239
neonate7 / 31097225
infant1 / 2362042
juvenile10 / 55556179
adult129 / 193912166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma6 / 17475343
breast (mammary gland) tumor3 / 9417831
cervical tumor4 / 34366116
chondrosarcoma8 / 8282396
colorectal tumor2 / 11424617
esophageal tumor4 / 17290231
gastrointestinal tumor6 / 11936950
germ cell tumor31 / 263845117
glioma1 / 1068839
head and neck tumor9 / 13630266
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor11 / 96359114
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia13 / 97250133
normal238 / 336030770
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites2 / 4001549
bladder8 / 29757268
blood15 / 123478121
bone5 / 7165569
bone marrow3 / 4880161
brain62 / 110098956
cervix5 / 48171103
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus4 / 20209197
eye8 / 21105437
heart8 / 8962689
intestine6 / 23447225
kidney10 / 21177747
larynx0 / 241450 
liver16 / 20774377
lung15 / 33697444
lymph0 / 442700 
lymph node8 / 9161087
mammary gland10 / 15327165
mouth17 / 67052253
muscle11 / 107715102
nerve3 / 15768190
ovary2 / 10205119
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta18 / 28082564
prostate9 / 18934547
salivary gland0 / 201550 
skin16 / 21057475
spleen9 / 53952166
stomach2 / 9661920
testis37 / 330442111
thymus9 / 81131110
thyroid1 / 4747321
tonsil1 / 1699958
trachea14 / 52413267
umbilical cord0 / 136800 
uterus31 / 232878133
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209308_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts57.15
Adipocyte31.3
AdrenalCortex33.7
Adrenalgland24.95
Amygdala23.95
Appendix36.95
AtrioventricularNode24.7
BDCA4+_DentriticCells87.95
Bonemarrow40.7
BronchialEpithelialCells45.8
CD105+_Endothelial43.6
CD14+_Monocytes78.9
CD19+_BCells(neg._sel.)113.6
CD33+_Myeloid162.95
CD34+103.3
CD4+_Tcells49.95
CD56+_NKCells110.1
CD71+_EarlyErythroid29.15
CD8+_Tcells43.15
CardiacMyocytes44.75
Caudatenucleus22.95
Cerebellum21.7
CerebellumPeduncles31.9
CiliaryGanglion22.05
CingulateCortex29.75
Colorectaladenocarcinoma32.7
DorsalRootGanglion24.9
FetalThyroid32.45
Fetalbrain26.3
Fetalliver28.3
Fetallung27.55
GlobusPallidus22.95
Heart40.9
Hypothalamus22.75
Kidney16.4
Leukemia_chronicMyelogenousK-56226.05
Leukemia_promyelocytic-HL-6030.3
Leukemialymphoblastic(MOLT-4)43.85
Liver42.5
Lung32.7
Lymphnode32.9
Lymphoma_burkitts(Daudi)55.1
Lymphoma_burkitts(Raji)56.4
MedullaOblongata20.9
OccipitalLobe21.35
OlfactoryBulb20.5
Ovary27.55
Pancreas26.2
PancreaticIslet34.9
ParietalLobe32.05
Pituitary34.8
Placenta36.25
Pons23.6
PrefrontalCortex20.4
Prostate33.95
Salivarygland27.3
SkeletalMuscle49.15
Skin27.4
SmoothMuscle37.45
Spinalcord24.8
SubthalamicNucleus21
SuperiorCervicalGanglion50.1
TemporalLobe25.4
Testis21.45
TestisGermCell29.75
TestisIntersitial26.6
TestisLeydigCell33.9
TestisSeminiferousTubule24.3
Thalamus23
Thymus25.75
Thyroid41.4
Tongue33.8
Tonsil31.9
Trachea28.5
TrigeminalGanglion37.7
Uterus45.65
UterusCorpus29.9
WholeBlood78.65
Wholebrain14.95
colon60.75
pineal_day50.24
pineal_night41.22
retina53.9
small_intestine48.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1338_PI416379584
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.39 ± 0.37
Basal Forebrain7.59 ± 0.15
Basal Part of Pons6.77 ± 0.25
Cerebellar Cortex7.34 ± 0.1
Cerebellar Nuclei7.64 ± 0.33
Claustrum7.11 ± 0.26
Epithalamus8.29 ± 0.52
Frontal Lobe7.32 ± 0.36
Globus Pallidus8.27 ± 0.32
Hypothalamus7.56 ± 0.41
Insula7.39 ± 0.24
Limbic Lobe7.29 ± 0.39
Mesencephalon7.57 ± 0.25
Myelencephalon7.42 ± 0.42
Occipital Lobe7.45 ± 0.43
Parietal Lobe7.25 ± 0.3
Pontine Tegmentum7.52 ± 0.31
Striatum8.08 ± 0.33
Subthalamus7.42 ± 0.13
Temporal Lobe7.27 ± 0.28
Thalamus7.38 ± 0.23
White Matter8.33 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Bnip2CBCerebellum0.4
0.93
Bnip2CTXCerebral cortex0.24
0.34
Bnip2HIPHippocampal region2.02
2.22
Bnip2HPFHippocampal formation1.66
1.83
Bnip2HYHypothalamus0.38
0.59
Bnip2LSXLateral septal complex0.21
0.3
Bnip2MBMidbrain1.04
2.13
Bnip2MYMedulla0.06
0.3
Bnip2OLFOlfactory bulb0.96
1.4
Bnip2PPons0.5
1.64
Bnip2PALPallidum0.09
0.06
Bnip2RHPRetrohippocampal region0.89
1.08
Bnip2sAMYStriatum-like amygdalar nuclei0.91
1.08
Bnip2STRStriatum0.37
0.38
Bnip2STRdStriatum dorsal region0.13
0.12
Bnip2STRvStriatum ventral region0.96
0.81
Bnip2THThalamus0.46
0.84
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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