AutismKB 2.0

Annotation Detail for SNX1


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Basic Information Top
Gene Symbol:SNX1 ( HsT17379,MGC8664,SNX1A,Vps5 )
Gene Full Name: sorting nexin 1
Band: 15q22.31
Quick LinksEntrez ID:6642; OMIM: 601272; Uniprot ID:SNX1_HUMAN; ENSEMBL ID: ENSG00000028528; HGNC ID: 11172
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus36 / 56401263
neonate3 / 3109796
infant2 / 2362084
juvenile1 / 5555617
adult245 / 1939121126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor36 / 94178382
cervical tumor8 / 34366232
chondrosarcoma6 / 8282372
colorectal tumor12 / 114246105
esophageal tumor5 / 17290289
gastrointestinal tumor5 / 11936941
germ cell tumor17 / 26384564
glioma10 / 10688393
head and neck tumor18 / 136302132
kidney tumor5 / 6895972
leukemia18 / 95842187
liver tumor8 / 9635983
lung tumor6 / 10312758
lymphoma5 / 7175569
non-neoplasia13 / 97250133
normal329 / 336030797
ovarian tumor2 / 7668226
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer10 / 10268097
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor17 / 125191135
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland2 / 3319760
ascites0 / 400150 
bladder4 / 29757134
blood22 / 123478178
bone6 / 7165583
bone marrow1 / 4880120
brain120 / 1100989108
cervix9 / 48171186
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus5 / 20209247
eye17 / 21105480
heart9 / 89626100
intestine21 / 23447289
kidney9 / 21177742
larynx6 / 24145248
liver17 / 20774381
lung24 / 33697471
lymph1 / 4427022
lymph node17 / 91610185
mammary gland50 / 153271326
mouth3 / 6705244
muscle32 / 107715297
nerve3 / 15768190
ovary5 / 10205148
pancreas31 / 214812144
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta18 / 28082564
prostate14 / 18934573
salivary gland0 / 201550 
skin16 / 21057475
spleen1 / 5395218
stomach5 / 9661951
testis20 / 33044260
thymus9 / 81131110
thyroid16 / 47473337
tonsil1 / 1699958
trachea4 / 5241376
umbilical cord2 / 13680146
uterus31 / 232878133
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214531_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts30.45
Adipocyte17.4
AdrenalCortex14.7
Adrenalgland12.55
Amygdala15.05
Appendix14.55
AtrioventricularNode11
BDCA4+_DentriticCells45.85
Bonemarrow14.4
BronchialEpithelialCells23.75
CD105+_Endothelial30.3
CD14+_Monocytes79.2
CD19+_BCells(neg._sel.)17.55
CD33+_Myeloid38.7
CD34+35.35
CD4+_Tcells14.45
CD56+_NKCells34.55
CD71+_EarlyErythroid10.05
CD8+_Tcells15.45
CardiacMyocytes17.5
Caudatenucleus12.6
Cerebellum9.85
CerebellumPeduncles15.45
CiliaryGanglion8.75
CingulateCortex14.1
Colorectaladenocarcinoma15.5
DorsalRootGanglion10
FetalThyroid119.6
Fetalbrain8.5
Fetalliver12.15
Fetallung24.8
GlobusPallidus9.35
Heart17.7
Hypothalamus16.6
Kidney12.15
Leukemia_chronicMyelogenousK-56210.45
Leukemia_promyelocytic-HL-6012.65
Leukemialymphoblastic(MOLT-4)11.6
Liver20.2
Lung50.8
Lymphnode12.4
Lymphoma_burkitts(Daudi)22.85
Lymphoma_burkitts(Raji)19.45
MedullaOblongata13.1
OccipitalLobe13.25
OlfactoryBulb11.25
Ovary9.3
Pancreas9.75
PancreaticIslet15.35
ParietalLobe15.1
Pituitary13.2
Placenta30.05
Pons10.4
PrefrontalCortex17.2
Prostate44.2
Salivarygland9.85
SkeletalMuscle16.7
Skin9.15
SmoothMuscle25.9
Spinalcord20.1
SubthalamicNucleus13
SuperiorCervicalGanglion16.35
TemporalLobe10.5
Testis10.7
TestisGermCell11.6
TestisIntersitial7.4
TestisLeydigCell14
TestisSeminiferousTubule11.55
Thalamus17.3
Thymus35.5
Thyroid80.95
Tongue11.5
Tonsil14.05
Trachea11.95
TrigeminalGanglion13.65
Uterus13.45
UterusCorpus12.95
WholeBlood58.3
Wholebrain23.7
colon15.75
pineal_day43.96
pineal_night45.72
retina16.225
small_intestine15.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5033_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.35 ± 0.35
Basal Forebrain7.61 ± 0.46
Basal Part of Pons7.39 ± 0.29
Cerebellar Cortex7.26 ± 0.16
Cerebellar Nuclei8.12 ± 0.4
Claustrum7.57 ± 0.36
Epithalamus7.33 ± 0.39
Frontal Lobe7.38 ± 0.32
Globus Pallidus8.38 ± 0.18
Hypothalamus7.05 ± 0.34
Insula7.28 ± 0.29
Limbic Lobe7.42 ± 0.35
Mesencephalon7.53 ± 0.39
Myelencephalon7.52 ± 0.37
Occipital Lobe7.69 ± 0.47
Parietal Lobe7.4 ± 0.31
Pontine Tegmentum7.54 ± 0.41
Striatum7.78 ± 0.4
Subthalamus7.55 ± 0.05
Temporal Lobe7.35 ± 0.27
Thalamus7.54 ± 0.27
White Matter8.98 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Snx1CBCerebellum28.95
38.09
Snx1CTXCerebral cortex85.06
68.71
Snx1HIPHippocampal region49.3
85.8
Snx1HPFHippocampal formation57.23
74.49
Snx1HYHypothalamus71.33
61.85
Snx1LSXLateral septal complex52.01
38.25
Snx1MBMidbrain59.11
56.67
Snx1MYMedulla59.09
63.41
Snx1OLFOlfactory bulb73.21
64.68
Snx1PPons60.6
62.16
Snx1PALPallidum75.01
74.63
Snx1RHPRetrohippocampal region71.41
62.52
Snx1sAMYStriatum-like amygdalar nuclei65.69
51.61
Snx1STRStriatum61.81
47.15
Snx1STRdStriatum dorsal region58.43
45.64
Snx1STRvStriatum ventral region73.69
50.93
Snx1THThalamus85.05
82.77
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00067692 10 122 131 FSDFLGLYEK Peptide Atlas
SNX1_HUMAN_2 12 2 13 ASGGGGCSASER PRIDE
SNX1_HUMAN_249 14 249 262 IVNHPTMLQDPDVR PRIDE
SNX1_HUMAN_272 14 272 285 AVGTQTLSGAGLLK PRIDE
SNX1_HUMAN_350 16 350 365 SLAMLGSSEDNTALSR PRIDE
SNX1_HUMAN_365 11 365 375 ALSQLAEVEEK PRIDE
SNX1_HUMAN_509 10 509 518 YWEAFLPEAK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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