AutismKB 2.0

Annotation Detail for SNX2


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Basic Information Top
Gene Symbol:SNX2 ( MGC5204,TRG-9 )
Gene Full Name: sorting nexin 2
Band: 5q23.2
Quick LinksEntrez ID:6643; OMIM: 605929; Uniprot ID:SNX2_HUMAN; ENSEMBL ID: ENSG00000205302; HGNC ID: 11173
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst10 / 62319160
fetus32 / 56401256
neonate16 / 31097514
infant4 / 23620169
juvenile9 / 55556161
adult162 / 193912183
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor4 / 9417842
cervical tumor4 / 34366116
chondrosarcoma13 / 82823156
colorectal tumor10 / 11424687
esophageal tumor2 / 17290115
gastrointestinal tumor5 / 11936941
germ cell tumor43 / 263845162
glioma6 / 10688356
head and neck tumor12 / 13630288
kidney tumor10 / 68959145
leukemia12 / 95842125
liver tumor11 / 96359114
lung tumor2 / 10312719
lymphoma5 / 7175569
non-neoplasia20 / 97250205
normal337 / 3360307100
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer5 / 10268048
retinoblastoma5 / 46356107
skin tumor18 / 124949144
soft tissue/muscle tissue tumor22 / 125191175
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites2 / 4001549
bladder4 / 29757134
blood25 / 123478202
bone13 / 71655181
bone marrow8 / 48801163
brain99 / 110098989
cervix8 / 48171166
connective tissue38 / 149255254
ear1 / 1621261
embryonic tissue19 / 21572288
esophagus4 / 20209197
eye13 / 21105461
heart10 / 89626111
intestine34 / 234472145
kidney32 / 211777151
larynx9 / 24145372
liver16 / 20774377
lung36 / 336974106
lymph3 / 4427067
lymph node9 / 9161098
mammary gland5 / 15327132
mouth3 / 6705244
muscle4 / 10771537
nerve1 / 1576863
ovary2 / 10205119
pancreas11 / 21481251
parathyroid6 / 20539292
pharynx19 / 41328459
pituitary gland2 / 16585120
placenta34 / 280825121
prostate10 / 18934552
salivary gland2 / 2015599
skin26 / 210574123
spleen21 / 53952389
stomach5 / 9661951
testis38 / 330442114
thymus14 / 81131172
thyroid2 / 4747342
tonsil1 / 1699958
trachea7 / 52413133
umbilical cord2 / 13680146
uterus22 / 23287894
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202113_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts138.3
Adipocyte23.3
AdrenalCortex8.25
Adrenalgland5.75
Amygdala19.85
Appendix8.1
AtrioventricularNode7.85
BDCA4+_DentriticCells152.45
Bonemarrow7.25
BronchialEpithelialCells28.65
CD105+_Endothelial59.5
CD14+_Monocytes226.1
CD19+_BCells(neg._sel.)553
CD33+_Myeloid322.35
CD34+130.9
CD4+_Tcells41.6
CD56+_NKCells66.6
CD71+_EarlyErythroid28.7
CD8+_Tcells31.25
CardiacMyocytes13.2
Caudatenucleus6.65
Cerebellum5.8
CerebellumPeduncles8.85
CiliaryGanglion6.2
CingulateCortex7.35
Colorectaladenocarcinoma12.05
DorsalRootGanglion6.85
FetalThyroid8.85
Fetalbrain6.85
Fetalliver27.8
Fetallung31.2
GlobusPallidus6
Heart9.7
Hypothalamus14.9
Kidney5.9
Leukemia_chronicMyelogenousK-56217.25
Leukemia_promyelocytic-HL-6056.85
Leukemialymphoblastic(MOLT-4)10.4
Liver10.85
Lung7.8
Lymphnode31.8
Lymphoma_burkitts(Daudi)60.8
Lymphoma_burkitts(Raji)79.35
MedullaOblongata6.85
OccipitalLobe12
OlfactoryBulb6.5
Ovary12.5
Pancreas6.25
PancreaticIslet34.1
ParietalLobe7.8
Pituitary18.15
Placenta17.6
Pons8
PrefrontalCortex14.45
Prostate8.35
Salivarygland18.15
SkeletalMuscle8.8
Skin7.9
SmoothMuscle54.55
Spinalcord9.65
SubthalamicNucleus6.75
SuperiorCervicalGanglion9.85
TemporalLobe6.55
Testis5.95
TestisGermCell22.05
TestisIntersitial8.45
TestisLeydigCell12.4
TestisSeminiferousTubule7.8
Thalamus12
Thymus5.25
Thyroid93.95
Tongue8.05
Tonsil47.9
Trachea11.5
TrigeminalGanglion8.5
Uterus17.7
UterusCorpus7.2
WholeBlood130.75
Wholebrain5.5
colon25
pineal_day14.52
pineal_night25.54
retina10.55
small_intestine11.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2316_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.84 ± 0.28
Basal Forebrain7.72 ± 0.22
Basal Part of Pons7.66 ± 0.17
Cerebellar Cortex7.65 ± 0.28
Cerebellar Nuclei7.74 ± 0.26
Claustrum8.07 ± 0.39
Epithalamus7.78 ± 0.23
Frontal Lobe7.7 ± 0.29
Globus Pallidus7.72 ± 0.19
Hypothalamus7.7 ± 0.18
Insula7.74 ± 0.21
Limbic Lobe7.91 ± 0.31
Mesencephalon7.73 ± 0.3
Myelencephalon7.73 ± 0.29
Occipital Lobe7.75 ± 0.28
Parietal Lobe7.68 ± 0.22
Pontine Tegmentum7.76 ± 0.26
Striatum7.94 ± 0.18
Subthalamus7.68 ± 0.12
Temporal Lobe7.72 ± 0.26
Thalamus7.71 ± 0.23
White Matter7.94 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Snx2CBCerebellum8.74
10.39
Snx2CTXCerebral cortex13.44
10.15
Snx2HIPHippocampal region18.85
22.02
Snx2HPFHippocampal formation15.07
16.06
Snx2HYHypothalamus1.19
0.98
Snx2LSXLateral septal complex2.24
1.58
Snx2MBMidbrain1.72
1.83
Snx2MYMedulla2.53
3.21
Snx2OLFOlfactory bulb10.8
8.54
Snx2PPons1.78
2.79
Snx2PALPallidum2.17
1.91
Snx2RHPRetrohippocampal region9.17
8.31
Snx2sAMYStriatum-like amygdalar nuclei2.57
1.92
Snx2STRStriatum1.98
1.54
Snx2STRdStriatum dorsal region1.89
1.55
Snx2STRvStriatum ventral region1.85
1.17
Snx2THThalamus4.19
4.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064300 14 270 283 AVNTQALSGAGILR Peptide Atlas
SNX2_HUMAN_0 0 0 0 KLHVSVEALVCHR PRIDE
SNX2_HUMAN_117 10 117 126 SMSAPVIFDR PRIDE
SNX2_HUMAN_260 10 260 269 QFLESSELPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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