AutismKB 2.0

Annotation Detail for SON


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Basic Information Top
Gene Symbol:SON ( BASS1,C21orf50,DBP-5,FLJ21099,FLJ33914,KIAA1019,NREBP,SON3 )
Gene Full Name: SON DNA binding protein
Band: 21q22.11
Quick LinksEntrez ID:6651; OMIM: 182465; Uniprot ID:SON_HUMAN; ENSEMBL ID: ENSG00000159140; HGNC ID: 11183
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst13 / 62319208
fetus127 / 564012225
neonate4 / 31097128
infant0 / 236200 
juvenile3 / 5555653
adult385 / 1939121198
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor25 / 94178265
cervical tumor2 / 3436658
chondrosarcoma20 / 82823241
colorectal tumor12 / 114246105
esophageal tumor1 / 1729057
gastrointestinal tumor9 / 11936975
germ cell tumor43 / 263845162
glioma11 / 106883102
head and neck tumor32 / 136302234
kidney tumor6 / 6895987
leukemia16 / 95842166
liver tumor33 / 96359342
lung tumor6 / 10312758
lymphoma19 / 71755264
non-neoplasia10 / 97250102
normal589 / 3360307175
ovarian tumor8 / 76682104
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer40 / 102680389
retinoblastoma10 / 46356215
skin tumor12 / 12494996
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor21 / 90257232
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites3 / 4001574
bladder3 / 29757100
blood39 / 123478315
bone18 / 71655251
bone marrow1 / 4880120
brain133 / 1100989120
cervix2 / 4817141
connective tissue18 / 149255120
ear5 / 16212308
embryonic tissue48 / 215722222
esophagus1 / 2020949
eye34 / 211054161
heart20 / 89626223
intestine21 / 23447289
kidney25 / 211777118
larynx4 / 24145165
liver101 / 207743486
lung34 / 336974100
lymph16 / 44270361
lymph node13 / 91610141
mammary gland35 / 153271228
mouth21 / 67052313
muscle20 / 107715185
nerve3 / 15768190
ovary10 / 10205197
pancreas22 / 214812102
parathyroid14 / 20539681
pharynx5 / 41328120
pituitary gland12 / 16585723
placenta32 / 280825113
prostate51 / 189345269
salivary gland0 / 201550 
skin23 / 210574109
spleen2 / 5395237
stomach8 / 9661982
testis47 / 330442142
thymus12 / 81131147
thyroid9 / 47473189
tonsil2 / 16999117
trachea10 / 52413190
umbilical cord0 / 136800 
uterus53 / 232878227
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201086_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts722.25
Adipocyte125.65
AdrenalCortex89.6
Adrenalgland85.05
Amygdala219.25
Appendix78.9
AtrioventricularNode79.15
BDCA4+_DentriticCells652.4
Bonemarrow104.9
BronchialEpithelialCells224.55
CD105+_Endothelial506.5
CD14+_Monocytes518.2
CD19+_BCells(neg._sel.)571
CD33+_Myeloid718.25
CD34+685.9
CD4+_Tcells1007.95
CD56+_NKCells685.55
CD71+_EarlyErythroid586.85
CD8+_Tcells942.6
CardiacMyocytes115.9
Caudatenucleus196.05
Cerebellum142.3
CerebellumPeduncles166.95
CiliaryGanglion82.7
CingulateCortex86
Colorectaladenocarcinoma184
DorsalRootGanglion79.4
FetalThyroid278.25
Fetalbrain236.3
Fetalliver191.35
Fetallung291.9
GlobusPallidus98.05
Heart7.4
Hypothalamus372.2
Kidney27.9
Leukemia_chronicMyelogenousK-562274
Leukemia_promyelocytic-HL-60201.4
Leukemialymphoblastic(MOLT-4)314.15
Liver13.45
Lung129.6
Lymphnode472.2
Lymphoma_burkitts(Daudi)417.45
Lymphoma_burkitts(Raji)137
MedullaOblongata105.3
OccipitalLobe193.7
OlfactoryBulb171.6
Ovary103.6
Pancreas100.75
PancreaticIslet257.7
ParietalLobe124.95
Pituitary377.85
Placenta243.7
Pons65.2
PrefrontalCortex247
Prostate280.25
Salivarygland220
SkeletalMuscle61.2
Skin73.2
SmoothMuscle256.25
Spinalcord178.3
SubthalamicNucleus75
SuperiorCervicalGanglion73.15
TemporalLobe35.75
Testis135.3
TestisGermCell258.6
TestisIntersitial227.15
TestisLeydigCell212.6
TestisSeminiferousTubule139.15
Thalamus186.6
Thymus315.75
Thyroid363.65
Tongue76.75
Tonsil336.15
Trachea164.35
TrigeminalGanglion75.25
Uterus355.05
UterusCorpus136.65
WholeBlood431.05
Wholebrain174.15
colon120.55
pineal_day455.76
pineal_night525.38
retina324.65
small_intestine104.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P402733
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.92 ± 0.54
Basal Forebrain3.87 ± 0.47
Basal Part of Pons3.82 ± 0.45
Cerebellar Cortex4.36 ± 0.27
Cerebellar Nuclei3.98 ± 0.42
Claustrum3.92 ± 0.68
Epithalamus4.29 ± 0.32
Frontal Lobe3.85 ± 0.53
Globus Pallidus3.84 ± 0.9
Hypothalamus3.63 ± 0.72
Insula3.78 ± 0.47
Limbic Lobe3.73 ± 0.53
Mesencephalon3.97 ± 0.61
Myelencephalon3.92 ± 0.59
Occipital Lobe4.22 ± 0.54
Parietal Lobe3.85 ± 0.57
Pontine Tegmentum3.84 ± 0.61
Striatum3.71 ± 0.65
Subthalamus4.02 ± 0.23
Temporal Lobe3.84 ± 0.56
Thalamus3.85 ± 0.63
White Matter4.94 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SonCBCerebellum98.97
91.67
SonCTXCerebral cortex74.82
65.51
SonHIPHippocampal region87.82
89.81
SonHPFHippocampal formation88.12
84.14
SonHYHypothalamus68.79
61.26
SonLSXLateral septal complex86.93
71.55
SonMBMidbrain61.09
57.7
SonMYMedulla73.73
68.5
SonOLFOlfactory bulb100
90.96
SonPPons66.12
62.72
SonPALPallidum63.2
58.49
SonRHPRetrohippocampal region88.3
76.02
SonsAMYStriatum-like amygdalar nuclei76.96
65.82
SonSTRStriatum83.26
69.75
SonSTRdStriatum dorsal region80.29
67.91
SonSTRvStriatum ventral region97.72
78.17
SonTHThalamus73.23
66.37
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001471 16 92 107 CVSVQTDPTDEIPTKK Peptide Atlas
SON_HUMAN_142 16 142 157 SHDDGNIDLESDSFLK PRIDE
SON_HUMAN_1678 22 1678 1699 DTEEPLPVKESDQTLAALLSPK PRIDE
SON_HUMAN_1687 13 1687 1699 ESDQTLAALLSPK PRIDE
SON_HUMAN_2 9 2 10 ATNIEQIFR PRIDE
SON_HUMAN_278 11 278 288 SVESTSPEPSK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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