AutismKB 2.0

Annotation Detail for SOS2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SOS2 ( FLJ25596 )
Gene Full Name: son of sevenless homolog 2 (Drosophila)
Band: 14q21.3
Quick LinksEntrez ID:6655; OMIM: 601247; Uniprot ID:SOS2_HUMAN; ENSEMBL ID: ENSG00000100485; HGNC ID: 11188
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult81 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia12 / 95842125
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal136 / 336030740
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder3 / 29757100
blood3 / 12347824
bone3 / 7165541
bone marrow4 / 4880181
brain26 / 110098923
cervix1 / 4817120
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye2 / 2110549
heart3 / 8962633
intestine3 / 23447212
kidney15 / 21177770
larynx1 / 2414541
liver8 / 20774338
lung8 / 33697423
lymph0 / 442700 
lymph node14 / 91610152
mammary gland6 / 15327139
mouth5 / 6705274
muscle4 / 10771537
nerve2 / 15768126
ovary2 / 10205119
pancreas4 / 21481218
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta28 / 28082599
prostate7 / 18934536
salivary gland1 / 2015549
skin5 / 21057423
spleen0 / 539520 
stomach2 / 9661920
testis16 / 33044248
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217644_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.25
Adipocyte5.7
AdrenalCortex7.3
Adrenalgland5
Amygdala5.85
Appendix7.55
AtrioventricularNode7
BDCA4+_DentriticCells7.45
Bonemarrow6
BronchialEpithelialCells5.65
CD105+_Endothelial5.8
CD14+_Monocytes6.35
CD19+_BCells(neg._sel.)6.15
CD33+_Myeloid9.25
CD34+7.4
CD4+_Tcells6.3
CD56+_NKCells16.7
CD71+_EarlyErythroid5.6
CD8+_Tcells5.85
CardiacMyocytes8.45
Caudatenucleus5.2
Cerebellum4.7
CerebellumPeduncles6.75
CiliaryGanglion5.7
CingulateCortex5.95
Colorectaladenocarcinoma5.7
DorsalRootGanglion4.7
FetalThyroid5.8
Fetalbrain5.65
Fetalliver5
Fetallung4.65
GlobusPallidus4.4
Heart8.2
Hypothalamus6
Kidney4.95
Leukemia_chronicMyelogenousK-5625.15
Leukemia_promyelocytic-HL-605.05
Leukemialymphoblastic(MOLT-4)4.45
Liver8.1
Lung6.25
Lymphnode4.8
Lymphoma_burkitts(Daudi)7.55
Lymphoma_burkitts(Raji)8.5
MedullaOblongata5.3
OccipitalLobe5.1
OlfactoryBulb4.5
Ovary3.95
Pancreas4.75
PancreaticIslet6.2
ParietalLobe6.3
Pituitary6.7
Placenta5.95
Pons5.55
PrefrontalCortex6.85
Prostate6.65
Salivarygland4.85
SkeletalMuscle9.1
Skin5.45
SmoothMuscle6.4
Spinalcord6.15
SubthalamicNucleus5.65
SuperiorCervicalGanglion7.45
TemporalLobe5.35
Testis4.9
TestisGermCell4.8
TestisIntersitial4.9
TestisLeydigCell6.1
TestisSeminiferousTubule4.85
Thalamus5.9
Thymus4.5
Thyroid7
Tongue6
Tonsil5.65
Trachea4.75
TrigeminalGanglion7
Uterus4.6
UterusCorpus6.3
WholeBlood6.35
Wholebrain4.6
colon5.85
pineal_day7.06
pineal_night7.02
retina6.925
small_intestine5.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P117546
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.25 ± 0.35
Basal Forebrain7.74 ± 0.26
Basal Part of Pons7.02 ± 0.3
Cerebellar Cortex7.31 ± 0.14
Cerebellar Nuclei7.64 ± 0.43
Claustrum7.49 ± 0.23
Epithalamus7.5 ± 0.3
Frontal Lobe7.35 ± 0.33
Globus Pallidus8.27 ± 0.21
Hypothalamus7.33 ± 0.2
Insula7.28 ± 0.17
Limbic Lobe7.32 ± 0.29
Mesencephalon7.66 ± 0.42
Myelencephalon7.49 ± 0.43
Occipital Lobe7.59 ± 0.34
Parietal Lobe7.4 ± 0.36
Pontine Tegmentum7.58 ± 0.29
Striatum8.1 ± 0.34
Subthalamus7.58 ± 0.16
Temporal Lobe7.34 ± 0.33
Thalamus7.64 ± 0.3
White Matter8.62 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sos2CBCerebellum64.13
96.98
Sos2CTXCerebral cortex58.72
45.9
Sos2HIPHippocampal region39.46
54.22
Sos2HPFHippocampal formation42.61
47.16
Sos2HYHypothalamus62.72
53.4
Sos2LSXLateral septal complex67.31
51.05
Sos2MBMidbrain45.64
43.56
Sos2MYMedulla55.92
60.82
Sos2OLFOlfactory bulb63.68
60.98
Sos2PPons47.79
50.6
Sos2PALPallidum45.82
41.9
Sos2RHPRetrohippocampal region47.92
38.42
Sos2sAMYStriatum-like amygdalar nuclei28.22
22.05
Sos2STRStriatum41.86
31.74
Sos2STRdStriatum dorsal region38.32
29.75
Sos2STRvStriatum ventral region51.68
35.73
Sos2THThalamus48.01
42.87
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00033012 19 1251 1269 DISTCPNSPSTPPSTPSPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved