AutismKB 2.0

Annotation Detail for SPARC


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Basic Information Top
Gene Symbol:SPARC ( ON )
Gene Full Name: secreted protein, acidic, cysteine-rich (osteonectin)
Band: 5q33.1
Quick LinksEntrez ID:6678; OMIM: 182120; Uniprot ID:SPRC_HUMAN; ENSEMBL ID: ENSG00000113140; HGNC ID: 11219
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body197 / 707612784
blastocyst44 / 62319706
fetus443 / 564012785
neonate51 / 310971640
infant6 / 23620254
juvenile22 / 55556395
adult1419 / 1939121731
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor31 / 127942423
bladder carcinoma9 / 17475515
breast (mammary gland) tumor40 / 94178424
cervical tumor1 / 3436629
chondrosarcoma233 / 828232813
colorectal tumor37 / 114246323
esophageal tumor7 / 17290404
gastrointestinal tumor75 / 119369628
germ cell tumor107 / 263845405
glioma84 / 106883785
head and neck tumor81 / 136302594
kidney tumor71 / 689591029
leukemia2 / 9584220
liver tumor36 / 96359373
lung tumor26 / 103127252
lymphoma14 / 71755195
non-neoplasia124 / 972501275
normal2285 / 3360307679
ovarian tumor37 / 76682482
pancreatic tumor121 / 1046161156
primitive neuroectodermal tumor of the CNS33 / 125680262
prostate cancer18 / 102680175
retinoblastoma0 / 463560 
skin tumor161 / 1249491288
soft tissue/muscle tissue tumor44 / 125191351
uterine tumor76 / 90257842
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue13 / 13106991
adrenal gland47 / 331971415
ascites0 / 400150 
bladder2 / 2975767
blood4 / 12347832
bone253 / 716553530
bone marrow109 / 488012233
brain560 / 1100989508
cervix4 / 4817183
connective tissue223 / 1492551494
ear132 / 162128142
embryonic tissue317 / 2157221469
esophagus8 / 20209395
eye142 / 211054672
heart70 / 89626781
intestine88 / 234472375
kidney97 / 211777458
larynx6 / 24145248
liver65 / 207743312
lung126 / 336974373
lymph2 / 4427045
lymph node8 / 9161087
mammary gland59 / 153271384
mouth34 / 67052507
muscle39 / 107715362
nerve29 / 157681839
ovary40 / 102051391
pancreas149 / 214812693
parathyroid12 / 20539584
pharynx4 / 4132896
pituitary gland6 / 16585361
placenta327 / 2808251164
prostate45 / 189345237
salivary gland6 / 20155297
skin310 / 2105741472
spleen14 / 53952259
stomach80 / 96619827
testis195 / 330442590
thymus5 / 8113161
thyroid43 / 47473905
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord50 / 136803654
uterus168 / 232878721
vascular32 / 51780617
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200665_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5
Adipocyte7145.25
AdrenalCortex607.35
Adrenalgland921.05
Amygdala978.05
Appendix910.85
AtrioventricularNode918.1
BDCA4+_DentriticCells24.25
Bonemarrow63.1
BronchialEpithelialCells323.75
CD105+_Endothelial57.3
CD14+_Monocytes98.45
CD19+_BCells(neg._sel.)61.9
CD33+_Myeloid58.5
CD34+171.45
CD4+_Tcells5.2
CD56+_NKCells20.75
CD71+_EarlyErythroid9.8
CD8+_Tcells4.1
CardiacMyocytes8236.9
Caudatenucleus731.55
Cerebellum589.9
CerebellumPeduncles549.3
CiliaryGanglion817.35
CingulateCortex193.3
Colorectaladenocarcinoma20.75
DorsalRootGanglion2058.6
FetalThyroid2456
Fetalbrain269.1
Fetalliver268.75
Fetallung2757.65
GlobusPallidus87.7
Heart340.4
Hypothalamus4432.45
Kidney152.15
Leukemia_chronicMyelogenousK-562241.3
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)4.2
Liver178.6
Lung1564.45
Lymphnode410.3
Lymphoma_burkitts(Daudi)6.8
Lymphoma_burkitts(Raji)24.65
MedullaOblongata148.05
OccipitalLobe403.2
OlfactoryBulb5282.85
Ovary235.45
Pancreas291.55
PancreaticIslet155.45
ParietalLobe268.05
Pituitary309.2
Placenta3206.3
Pons214.9
PrefrontalCortex577.9
Prostate483
Salivarygland89.7
SkeletalMuscle68
Skin354.6
SmoothMuscle8046.45
Spinalcord4845.3
SubthalamicNucleus150.65
SuperiorCervicalGanglion299.75
TemporalLobe48.4
Testis1607.75
TestisGermCell3858.3
TestisIntersitial1430.75
TestisLeydigCell828
TestisSeminiferousTubule1321.45
Thalamus1489
Thymus278
Thyroid1211.15
Tongue101.8
Tonsil182.1
Trachea696.7
TrigeminalGanglion1087.85
Uterus2212.4
UterusCorpus1270.75
WholeBlood529.1
Wholebrain380.8
colon423.75
pineal_day1509.48
pineal_night1267.46
retina3519.625
small_intestine1132.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P7642
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.49 ± 0.79
Basal Forebrain10.81 ± 0.65
Basal Part of Pons9.8 ± 0.35
Cerebellar Cortex10.26 ± 0.27
Cerebellar Nuclei11.02 ± 0.94
Claustrum9.2 ± 0.46
Epithalamus11.55 ± 0.27
Frontal Lobe10.72 ± 0.75
Globus Pallidus13.84 ± 0.84
Hypothalamus11.85 ± 0.37
Insula10.78 ± 0.61
Limbic Lobe10.29 ± 0.95
Mesencephalon11.39 ± 0.66
Myelencephalon10.82 ± 0.63
Occipital Lobe10.07 ± 0.57
Parietal Lobe10.1 ± 0.71
Pontine Tegmentum11.04 ± 0.44
Striatum11.79 ± 0.9
Subthalamus10.94 ± 0.44
Temporal Lobe10.41 ± 0.6
Thalamus11.28 ± 0.5
White Matter12.26 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SparcCBCerebellum81.92
100
SparcCTXCerebral cortex50.59
44.41
SparcHIPHippocampal region53.37
68.72
SparcHPFHippocampal formation55.21
62.71
SparcHYHypothalamus94.05
100
SparcLSXLateral septal complex59.5
71.86
SparcMBMidbrain92.89
100
SparcMYMedulla98.51
100
SparcOLFOlfactory bulb71.5
71.89
SparcPPons96.67
100
SparcPALPallidum88.3
99.04
SparcRHPRetrohippocampal region56.26
52.33
SparcsAMYStriatum-like amygdalar nuclei68.02
73.94
SparcSTRStriatum47
45.14
SparcSTRdStriatum dorsal region40.04
37.34
SparcSTRvStriatum ventral region51.72
41.68
SparcTHThalamus81.37
94.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010750 10 141 150 LHLDYIGPCK Peptide Atlas
SPRC_HUMAN_204 14 204 217 RLEAGDHPVELLAR PRIDE
SPRC_HUMAN_205 13 205 217 LEAGDHPVELLAR PRIDE
SPRC_HUMAN_256 12 256 267 APLIPMEHCTTR PRIDE
SPRC_HUMAN_257 12 257 268 APLIPMEHCTTR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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