AutismKB 2.0

Annotation Detail for SPI1


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Basic Information Top
Gene Symbol:SPI1 ( OF,PU.1,SFPI1,SPI-1,SPI-A )
Gene Full Name: spleen focus forming virus (SFFV) proviral integration oncogene spi1
Band: 11p11.2
Quick LinksEntrez ID:6688; OMIM: 165170; Uniprot ID:SPI1_HUMAN; ENSEMBL ID: ENSG00000066336; HGNC ID: 11241
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus13 / 56401223
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult65 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor4 / 26384515
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor3 / 6895943
leukemia6 / 9584262
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma6 / 7175583
non-neoplasia5 / 9725051
normal98 / 336030729
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood27 / 123478218
bone0 / 716550 
bone marrow0 / 488010 
brain15 / 110098913
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye6 / 21105428
heart1 / 8962611
intestine2 / 2344728
kidney4 / 21177718
larynx0 / 241450 
liver2 / 2077439
lung15 / 33697444
lymph6 / 44270135
lymph node16 / 91610174
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen7 / 53952129
stomach2 / 9661920
testis1 / 3304423
thymus3 / 8113136
thyroid0 / 474730 
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205312_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.4
Adipocyte4.05
AdrenalCortex4.3
Adrenalgland3.5
Amygdala4.35
Appendix4.15
AtrioventricularNode3.2
BDCA4+_DentriticCells30.2
Bonemarrow4.2
BronchialEpithelialCells4.05
CD105+_Endothelial4.15
CD14+_Monocytes217.05
CD19+_BCells(neg._sel.)10.15
CD33+_Myeloid136.05
CD34+5.3
CD4+_Tcells4.5
CD56+_NKCells12.05
CD71+_EarlyErythroid3.9
CD8+_Tcells3.9
CardiacMyocytes5.5
Caudatenucleus3.7
Cerebellum3.35
CerebellumPeduncles4.65
CiliaryGanglion2.9
CingulateCortex4.2
Colorectaladenocarcinoma4.1
DorsalRootGanglion3.2
FetalThyroid4
Fetalbrain4.05
Fetalliver3.85
Fetallung3.45
GlobusPallidus3.05
Heart5.8
Hypothalamus4.45
Kidney3.35
Leukemia_chronicMyelogenousK-5623.7
Leukemia_promyelocytic-HL-603.65
Leukemialymphoblastic(MOLT-4)3.25
Liver5.5
Lung34.55
Lymphnode3.6
Lymphoma_burkitts(Daudi)5.25
Lymphoma_burkitts(Raji)20.05
MedullaOblongata3.75
OccipitalLobe3.7
OlfactoryBulb3.25
Ovary2.75
Pancreas3.3
PancreaticIslet4.4
ParietalLobe4.4
Pituitary4.85
Placenta4.75
Pons3.9
PrefrontalCortex5.2
Prostate4.8
Salivarygland3.3
SkeletalMuscle4.85
Skin3.15
SmoothMuscle4.65
Spinalcord4.4
SubthalamicNucleus3.8
SuperiorCervicalGanglion7.05
TemporalLobe3.75
Testis3.5
TestisGermCell3.35
TestisIntersitial3.45
TestisLeydigCell4.1
TestisSeminiferousTubule3.55
Thalamus4.2
Thymus3.25
Thyroid5.2
Tongue4.65
Tonsil4.05
Trachea3.45
TrigeminalGanglion4.15
Uterus3.35
UterusCorpus3.8
WholeBlood268.9
Wholebrain3.45
colon4.15
pineal_day5.22
pineal_night5.02
retina5.125
small_intestine4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P115998
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.24 ± 1.01
Basal Forebrain2.85 ± 0.5
Basal Part of Pons3.22 ± 0.37
Cerebellar Cortex2.56 ± 0.6
Cerebellar Nuclei3.7 ± 0.66
Claustrum3.57 ± 0.82
Epithalamus3.86 ± 0.6
Frontal Lobe3.02 ± 0.88
Globus Pallidus4.89 ± 0.33
Hypothalamus2.83 ± 0.97
Insula2.85 ± 0.44
Limbic Lobe3.24 ± 0.78
Mesencephalon3.27 ± 0.93
Myelencephalon3.02 ± 0.75
Occipital Lobe2.98 ± 0.83
Parietal Lobe2.99 ± 0.86
Pontine Tegmentum3.13 ± 0.98
Striatum3.61 ± 0.58
Subthalamus3.09 ± 1.01
Temporal Lobe3.08 ± 0.79
Thalamus3.2 ± 0.67
White Matter4.51 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sfpi1CBCerebellum3.13
5.26
Sfpi1CTXCerebral cortex3.12
2.85
Sfpi1HIPHippocampal region1.21
1.22
Sfpi1HPFHippocampal formation1.03
0.93
Sfpi1HYHypothalamus0.31
0.46
Sfpi1LSXLateral septal complex0.36
0.35
Sfpi1MBMidbrain1.56
2.16
Sfpi1MYMedulla2.3
2.81
Sfpi1OLFOlfactory bulb2.06
2.61
Sfpi1PPons1.71
2.12
Sfpi1PALPallidum0.88
0.9
Sfpi1RHPRetrohippocampal region0.73
0.52
Sfpi1sAMYStriatum-like amygdalar nuclei0.08
0.11
Sfpi1STRStriatum0.7
0.65
Sfpi1STRdStriatum dorsal region0.6
0.66
Sfpi1STRvStriatum ventral region1.61
1
Sfpi1THThalamus0.53
0.59
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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