AutismKB 2.0

Annotation Detail for SPRR2A


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Basic Information Top
Gene Symbol:SPRR2A ( - )
Gene Full Name: small proline-rich protein 2A
Band: 1q21.3
Quick LinksEntrez ID:6700; OMIM: 182267; Uniprot ID:SPR2A_HUMAN; ENSEMBL ID: ENSG00000241794; HGNC ID: 11261
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult77 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor71 / 136302520
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal7 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix1 / 4817120
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx3 / 24145124
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth11 / 67052164
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx61 / 413281475
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208539_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.8
Adipocyte9.3
AdrenalCortex13.3
Adrenalgland9.25
Amygdala9.7
Appendix34.55
AtrioventricularNode13.3
BDCA4+_DentriticCells7.7
Bonemarrow28.4
BronchialEpithelialCells29.8
CD105+_Endothelial8
CD14+_Monocytes8.65
CD19+_BCells(neg._sel.)8.25
CD33+_Myeloid10.2
CD34+10.1
CD4+_Tcells7.75
CD56+_NKCells9.15
CD71+_EarlyErythroid9.15
CD8+_Tcells6.9
CardiacMyocytes20
Caudatenucleus8.05
Cerebellum14.3
CerebellumPeduncles10.65
CiliaryGanglion11
CingulateCortex9.8
Colorectaladenocarcinoma9.35
DorsalRootGanglion8.65
FetalThyroid9.85
Fetalbrain10.3
Fetalliver19.75
Fetallung7.85
GlobusPallidus7.95
Heart22.95
Hypothalamus9.3
Kidney11.2
Leukemia_chronicMyelogenousK-5627.8
Leukemia_promyelocytic-HL-608.25
Leukemialymphoblastic(MOLT-4)9.45
Liver50.2
Lung31.6
Lymphnode7.8
Lymphoma_burkitts(Daudi)12.8
Lymphoma_burkitts(Raji)15.5
MedullaOblongata11
OccipitalLobe8.25
OlfactoryBulb6.85
Ovary10.3
Pancreas12.85
PancreaticIslet19.45
ParietalLobe15.9
Pituitary17.3
Placenta12.15
Pons10.3
PrefrontalCortex10.65
Prostate11.1
Salivarygland8.15
SkeletalMuscle53.45
Skin13.9
SmoothMuscle12.4
Spinalcord9.85
SubthalamicNucleus8.2
SuperiorCervicalGanglion28.85
TemporalLobe9
Testis13.95
TestisGermCell8.2
TestisIntersitial10.3
TestisLeydigCell18.4
TestisSeminiferousTubule8.35
Thalamus9.4
Thymus8.85
Thyroid16.3
Tongue8336.5
Tonsil1532.05
Trachea16.3
TrigeminalGanglion13.2
Uterus7.65
UterusCorpus10.2
WholeBlood15.95
Wholebrain8.8
colon10.1
pineal_day9.88
pineal_night10.22
retina10.775
small_intestine8.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_29_PI416383280
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.28 ± 1.04
Basal Forebrain1.77 ± 0.2
Basal Part of Pons1.55 ± 0.41
Cerebellar Cortex1.7 ± 0.62
Cerebellar Nuclei2.2 ± 0.74
Claustrum2.82 ± 0.9
Epithalamus1.63 ± 0.69
Frontal Lobe1.75 ± 0.73
Globus Pallidus2.43 ± 0.28
Hypothalamus2.06 ± 0.65
Insula1.68 ± 0.49
Limbic Lobe1.9 ± 0.61
Mesencephalon2.1 ± 0.74
Myelencephalon1.91 ± 0.66
Occipital Lobe2.04 ± 0.63
Parietal Lobe1.9 ± 0.69
Pontine Tegmentum1.97 ± 0.73
Striatum2.12 ± 0.61
Subthalamus2.01 ± 0.67
Temporal Lobe1.82 ± 0.63
Thalamus1.85 ± 0.62
White Matter2.32 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sprr2aCBCerebellum0.64
0.93
Sprr2aCTXCerebral cortex0.33
0.32
Sprr2aHIPHippocampal region0.97
1.78
Sprr2aHPFHippocampal formation0.82
1.17
Sprr2aHYHypothalamus0.43
0.23
Sprr2aLSXLateral septal complex0.06
0.19
Sprr2aMBMidbrain0.41
0.4
Sprr2aMYMedulla0.47
0.69
Sprr2aOLFOlfactory bulb1.67
2.99
Sprr2aPPons0.36
0.41
Sprr2aPALPallidum0.14
0.18
Sprr2aRHPRetrohippocampal region0.59
0.35
Sprr2asAMYStriatum-like amygdalar nuclei0.27
0.26
Sprr2aSTRStriatum1.35
1.8
Sprr2aSTRdStriatum dorsal region2.06
2.87
Sprr2aSTRvStriatum ventral region0.31
0.19
Sprr2aTHThalamus0.21
0.19
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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