AutismKB 2.0

Annotation Detail for SQLE


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Basic Information Top
Gene Symbol:SQLE ( FLJ30795 )
Gene Full Name: squalene epoxidase
Band: 8q24.13
Quick LinksEntrez ID:6713; OMIM: 602019; Uniprot ID:ERG1_HUMAN; ENSEMBL ID: ENSG00000104549; HGNC ID: 11279
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst1 / 6231916
fetus54 / 56401295
neonate3 / 3109796
infant1 / 2362042
juvenile16 / 55556287
adult122 / 193912162
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor4 / 34366116
chondrosarcoma3 / 8282336
colorectal tumor17 / 114246148
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor27 / 263845102
glioma7 / 10688365
head and neck tumor15 / 136302110
kidney tumor6 / 6895987
leukemia11 / 95842114
liver tumor7 / 9635972
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal228 / 336030767
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer24 / 102680233
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland6 / 33197180
ascites3 / 4001574
bladder2 / 2975767
blood8 / 12347864
bone4 / 7165555
bone marrow9 / 48801184
brain97 / 110098988
cervix5 / 48171103
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye11 / 21105452
heart1 / 8962611
intestine23 / 23447298
kidney12 / 21177756
larynx1 / 2414541
liver12 / 20774357
lung9 / 33697426
lymph2 / 4427045
lymph node2 / 9161021
mammary gland6 / 15327139
mouth7 / 67052104
muscle2 / 10771518
nerve1 / 1576863
ovary5 / 10205148
pancreas10 / 21481246
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta15 / 28082553
prostate28 / 189345147
salivary gland0 / 201550 
skin7 / 21057433
spleen0 / 539520 
stomach2 / 9661920
testis95 / 330442287
thymus2 / 8113124
thyroid5 / 47473105
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus7 / 23287830
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213562_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts29.05
Adipocyte7.85
AdrenalCortex8.65
Adrenalgland6.6
Amygdala7.6
Appendix8.4
AtrioventricularNode6.9
BDCA4+_DentriticCells7.15
Bonemarrow8.1
BronchialEpithelialCells76.55
CD105+_Endothelial7.35
CD14+_Monocytes7.8
CD19+_BCells(neg._sel.)7.65
CD33+_Myeloid9.15
CD34+8.85
CD4+_Tcells7.6
CD56+_NKCells8.1
CD71+_EarlyErythroid7.1
CD8+_Tcells6.75
CardiacMyocytes10.3
Caudatenucleus6.75
Cerebellum6.1
CerebellumPeduncles8.9
CiliaryGanglion5.95
CingulateCortex7.8
Colorectaladenocarcinoma9.35
DorsalRootGanglion6.45
FetalThyroid7.35
Fetalbrain8.4
Fetalliver13.2
Fetallung5.9
GlobusPallidus5.8
Heart11.1
Hypothalamus7.9
Kidney6.65
Leukemia_chronicMyelogenousK-56290.8
Leukemia_promyelocytic-HL-6015.05
Leukemialymphoblastic(MOLT-4)11.25
Liver10.35
Lung8.1
Lymphnode6.05
Lymphoma_burkitts(Daudi)10.35
Lymphoma_burkitts(Raji)11.5
MedullaOblongata7.4
OccipitalLobe6.6
OlfactoryBulb5.65
Ovary5.25
Pancreas6.2
PancreaticIslet7.95
ParietalLobe8.3
Pituitary8.6
Placenta7.4
Pons7.35
PrefrontalCortex8.85
Prostate8.45
Salivarygland6.3
SkeletalMuscle10.15
Skin6.45
SmoothMuscle8.35
Spinalcord7.9
SubthalamicNucleus7.05
SuperiorCervicalGanglion12.2
TemporalLobe7
Testis7.25
TestisGermCell9.2
TestisIntersitial6.35
TestisLeydigCell11.1
TestisSeminiferousTubule6.4
Thalamus7.8
Thymus5.6
Thyroid9
Tongue7.9
Tonsil7.4
Trachea6.1
TrigeminalGanglion9.1
Uterus5.8
UterusCorpus7.25
WholeBlood7.95
Wholebrain6.1
colon7.55
pineal_day9
pineal_night8.92
retina9.125
small_intestine7.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7835_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.02 ± 0.53
Basal Forebrain7.09 ± 0.38
Basal Part of Pons7.31 ± 0.3
Cerebellar Cortex7.34 ± 0.31
Cerebellar Nuclei7.67 ± 0.41
Claustrum8.11 ± 0.35
Epithalamus7.55 ± 0.35
Frontal Lobe7.52 ± 0.33
Globus Pallidus6.63 ± 0.4
Hypothalamus7.52 ± 0.38
Insula7.42 ± 0.29
Limbic Lobe7.3 ± 0.43
Mesencephalon7.05 ± 0.56
Myelencephalon7.36 ± 0.5
Occipital Lobe6.83 ± 0.47
Parietal Lobe7.1 ± 0.4
Pontine Tegmentum7.44 ± 0.35
Striatum6.82 ± 0.36
Subthalamus7.31 ± 0.26
Temporal Lobe7.43 ± 0.39
Thalamus7.27 ± 0.47
White Matter8.97 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SqleCBCerebellum61.94
92.01
SqleCTXCerebral cortex100
100
SqleHIPHippocampal region76.63
100
SqleHPFHippocampal formation89.66
100
SqleHYHypothalamus79.84
83.51
SqleLSXLateral septal complex70.31
61.09
SqleMBMidbrain83.78
94.04
SqleMYMedulla66.58
85.94
SqleOLFOlfactory bulb100
100
SqlePPons82.98
100
SqlePALPallidum60.34
67.45
SqleRHPRetrohippocampal region100
100
SqlesAMYStriatum-like amygdalar nuclei86.4
83.39
SqleSTRStriatum60.01
55.66
SqleSTRdStriatum dorsal region56.39
54.32
SqleSTRvStriatum ventral region54.42
43.51
SqleTHThalamus82.49
90.26
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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