AutismKB 2.0

Annotation Detail for SRC


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Basic Information Top
Gene Symbol:SRC ( ASV,SRC1,c-SRC,p60-Src )
Gene Full Name: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
Band: 20q11.23
Quick LinksEntrez ID:6714; OMIM: 190090; Uniprot ID:SRC_HUMAN; ENSEMBL ID: ENSG00000197122; HGNC ID: 11283
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor8 / 26384530
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor7 / 10312767
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal56 / 336030716
ovarian tumor3 / 7668239
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder4 / 29757134
blood1 / 1234788
bone4 / 7165555
bone marrow0 / 488010 
brain14 / 110098912
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine10 / 23447242
kidney5 / 21177723
larynx1 / 2414541
liver1 / 2077434
lung22 / 33697465
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth3 / 6705244
muscle3 / 10771527
nerve1 / 1576863
ovary3 / 10205129
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate6 / 18934531
salivary gland0 / 201550 
skin12 / 21057456
spleen0 / 539520 
stomach4 / 9661941
testis5 / 33044215
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213324_at
Cell line Expression level Expression bar
721_B_lymphoblasts39.35
Adipocyte39.4
AdrenalCortex60.35
Adrenalgland55.85
Amygdala36.2
Appendix33.9
AtrioventricularNode25.2
BDCA4+_DentriticCells42.45
Bonemarrow33.65
BronchialEpithelialCells35.85
CD105+_Endothelial25.5
CD14+_Monocytes37.05
CD19+_BCells(neg._sel.)29.65
CD33+_Myeloid43
CD34+44.05
CD4+_Tcells35.75
CD56+_NKCells31.65
CD71+_EarlyErythroid30.2
CD8+_Tcells19.85
CardiacMyocytes41.3
Caudatenucleus44.85
Cerebellum46.4
CerebellumPeduncles38.55
CiliaryGanglion23.35
CingulateCortex34.8
Colorectaladenocarcinoma36.2
DorsalRootGanglion25.75
FetalThyroid33.5
Fetalbrain39.6
Fetalliver35.9
Fetallung37.35
GlobusPallidus24.6
Heart55.45
Hypothalamus49.2
Kidney40.75
Leukemia_chronicMyelogenousK-56235
Leukemia_promyelocytic-HL-6029.2
Leukemialymphoblastic(MOLT-4)32.05
Liver46.05
Lung66.65
Lymphnode28.55
Lymphoma_burkitts(Daudi)55.3
Lymphoma_burkitts(Raji)46.35
MedullaOblongata35.85
OccipitalLobe30.05
OlfactoryBulb31.1
Ovary22.5
Pancreas36.3
PancreaticIslet45.75
ParietalLobe36
Pituitary64.6
Placenta35.5
Pons32.05
PrefrontalCortex44.2
Prostate70.55
Salivarygland26.95
SkeletalMuscle37.9
Skin25.45
SmoothMuscle38.05
Spinalcord35.85
SubthalamicNucleus29.75
SuperiorCervicalGanglion37.85
TemporalLobe31
Testis52.9
TestisGermCell57.05
TestisIntersitial27.95
TestisLeydigCell32.6
TestisSeminiferousTubule30.3
Thalamus33.85
Thymus27.55
Thyroid43.95
Tongue33.35
Tonsil34.05
Trachea46.15
TrigeminalGanglion23.65
Uterus38.65
UterusCorpus37.85
WholeBlood38.25
Wholebrain35.5
colon37.75
pineal_day41.52
pineal_night31.58
retina53.725
small_intestine51.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17088_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.67 ± 0.86
Basal Forebrain3.28 ± 0.57
Basal Part of Pons3.06 ± 0.52
Cerebellar Cortex3.28 ± 0.69
Cerebellar Nuclei3.43 ± 0.89
Claustrum3.99 ± 1.4
Epithalamus2.85 ± 0.7
Frontal Lobe3.28 ± 0.77
Globus Pallidus2.97 ± 0.89
Hypothalamus3.31 ± 0.68
Insula2.93 ± 0.94
Limbic Lobe3.38 ± 0.92
Mesencephalon3.36 ± 0.95
Myelencephalon3.54 ± 0.89
Occipital Lobe3.78 ± 0.73
Parietal Lobe3.3 ± 0.8
Pontine Tegmentum3.62 ± 0.74
Striatum3.28 ± 1.02
Subthalamus3.3 ± 0.45
Temporal Lobe3.48 ± 0.84
Thalamus3.5 ± 0.82
White Matter2.62 ± 1.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SrcCBCerebellum34.42
71.91
SrcCTXCerebral cortex100
100
SrcHIPHippocampal region100
100
SrcHPFHippocampal formation100
100
SrcHYHypothalamus61.8
56.44
SrcLSXLateral septal complex74.82
65.78
SrcMBMidbrain53.52
53.18
SrcMYMedulla26.44
29.26
SrcOLFOlfactory bulb100
100
SrcPPons32.34
33.65
SrcPALPallidum76.9
77.73
SrcRHPRetrohippocampal region100
100
SrcsAMYStriatum-like amygdalar nuclei100
100
SrcSTRStriatum100
98.74
SrcSTRdStriatum dorsal region100
87.75
SrcSTRvStriatum ventral region100
100
SrcTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000173 13 392 404 AANILVGENLVCK Peptide Atlas
SRC_HUMAN_346 13 346 358 GSLLDFLKGETGK PRIDE
SRC_HUMAN_359 23 359 381 YLRLPQLVDMAAQIASGMAYVER PRIDE
SRC_HUMAN_362 20 362 381 LPQLVDMAAQIASGMAYVER PRIDE
SRC_HUMAN_391 13 391 403 AANILVGENLVCK PRIDE
SRC_HUMAN_430 11 430 440 WTAPEAALYGR PRIDE
SRC_HUMAN_445 16 445 460 SDVWSFGILLTELTTK PRIDE
SRC_HUMAN_62 16 62 77 LFGGFNSSDTVTSPQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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