AutismKB 2.0

Annotation Detail for SRM


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Basic Information Top
Gene Symbol:SRM ( PAPT,SPDSY,SPS1,SRML1 )
Gene Full Name: spermidine synthase
Band: 1p36.22
Quick LinksEntrez ID:6723; OMIM: 182891; Uniprot ID:SPEE_HUMAN; ENSEMBL ID: ENSG00000116649; HGNC ID: 11296
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus24 / 56401242
neonate1 / 3109732
infant1 / 2362042
juvenile0 / 555560 
adult161 / 193912183
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor16 / 94178169
cervical tumor5 / 34366145
chondrosarcoma6 / 8282372
colorectal tumor16 / 114246140
esophageal tumor0 / 172900 
gastrointestinal tumor20 / 119369167
germ cell tumor16 / 26384560
glioma14 / 106883130
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor4 / 9635941
lung tumor17 / 103127164
lymphoma17 / 71755236
non-neoplasia1 / 9725010
normal158 / 336030747
ovarian tumor10 / 76682130
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS19 / 125680151
prostate cancer17 / 102680165
retinoblastoma5 / 46356107
skin tumor48 / 124949384
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites4 / 4001599
bladder3 / 29757100
blood10 / 12347880
bone6 / 7165583
bone marrow1 / 4880120
brain173 / 1100989157
cervix5 / 48171103
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye10 / 21105447
heart5 / 8962655
intestine25 / 234472106
kidney5 / 21177723
larynx2 / 2414582
liver5 / 20774324
lung27 / 33697480
lymph8 / 44270180
lymph node15 / 91610163
mammary gland21 / 153271137
mouth2 / 6705229
muscle14 / 107715129
nerve1 / 1576863
ovary15 / 102051146
pancreas21 / 21481297
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta14 / 28082549
prostate33 / 189345174
salivary gland4 / 20155198
skin54 / 210574256
spleen1 / 5395218
stomach4 / 9661941
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord1 / 1368073
uterus16 / 23287868
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201516_at
Cell line Expression level Expression bar
721_B_lymphoblasts1945.7
Adipocyte215
AdrenalCortex160.45
Adrenalgland129.35
Amygdala267.15
Appendix110.4
AtrioventricularNode107.85
BDCA4+_DentriticCells656.1
Bonemarrow129.4
BronchialEpithelialCells169.5
CD105+_Endothelial574.45
CD14+_Monocytes173.1
CD19+_BCells(neg._sel.)276.65
CD33+_Myeloid212.3
CD34+991.3
CD4+_Tcells220.95
CD56+_NKCells264.1
CD71+_EarlyErythroid77.75
CD8+_Tcells170.7
CardiacMyocytes460.65
Caudatenucleus175.6
Cerebellum133.45
CerebellumPeduncles181.75
CiliaryGanglion110.6
CingulateCortex183.95
Colorectaladenocarcinoma285
DorsalRootGanglion114.2
FetalThyroid129.25
Fetalbrain207.15
Fetalliver134.15
Fetallung180.45
GlobusPallidus97.6
Heart334.9
Hypothalamus177.05
Kidney77.45
Leukemia_chronicMyelogenousK-562280.85
Leukemia_promyelocytic-HL-601272.7
Leukemialymphoblastic(MOLT-4)275.75
Liver273
Lung250.6
Lymphnode156.6
Lymphoma_burkitts(Daudi)1092.85
Lymphoma_burkitts(Raji)1916.8
MedullaOblongata152.85
OccipitalLobe148.5
OlfactoryBulb156.55
Ovary116
Pancreas102.1
PancreaticIslet175.1
ParietalLobe169.35
Pituitary120.25
Placenta147.15
Pons155.1
PrefrontalCortex183.3
Prostate195.85
Salivarygland90.6
SkeletalMuscle178.9
Skin77.45
SmoothMuscle544.9
Spinalcord172.2
SubthalamicNucleus130.7
SuperiorCervicalGanglion180.4
TemporalLobe147.55
Testis143.4
TestisGermCell140.45
TestisIntersitial125.25
TestisLeydigCell134.6
TestisSeminiferousTubule119.7
Thalamus221.25
Thymus126.25
Thyroid207.95
Tongue115.4
Tonsil188.05
Trachea117.55
TrigeminalGanglion118.5
Uterus111.2
UterusCorpus102.7
WholeBlood132.25
Wholebrain180.1
colon106.5
pineal_day238.9
pineal_night256.58
retina213.1
small_intestine124.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7644_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.07 ± 0.42
Basal Forebrain6.16 ± 0.29
Basal Part of Pons6.37 ± 0.54
Cerebellar Cortex6.21 ± 0.49
Cerebellar Nuclei5.77 ± 0.44
Claustrum5.41 ± 0.62
Epithalamus6.19 ± 0.37
Frontal Lobe6.42 ± 0.49
Globus Pallidus5.84 ± 0.3
Hypothalamus6.28 ± 0.61
Insula6.55 ± 0.3
Limbic Lobe6.33 ± 0.52
Mesencephalon6.2 ± 0.48
Myelencephalon6.22 ± 0.53
Occipital Lobe5.77 ± 0.52
Parietal Lobe6.08 ± 0.44
Pontine Tegmentum6.08 ± 0.54
Striatum6.39 ± 0.52
Subthalamus5.4 ± 0.37
Temporal Lobe6.38 ± 0.46
Thalamus6.24 ± 0.51
White Matter5.39 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SrmCBCerebellum34.86
49.86
SrmCTXCerebral cortex76.01
55.76
SrmHIPHippocampal region45.16
56.67
SrmHPFHippocampal formation54.26
53.8
SrmHYHypothalamus34.62
21.94
SrmLSXLateral septal complex28.69
20.29
SrmMBMidbrain26.64
21.72
SrmMYMedulla54.33
52.99
SrmOLFOlfactory bulb63.51
45.82
SrmPPons40.39
35.14
SrmPALPallidum39.79
31.12
SrmRHPRetrohippocampal region65.75
50.47
SrmsAMYStriatum-like amygdalar nuclei51.41
31.68
SrmSTRStriatum85.14
56.95
SrmSTRdStriatum dorsal region94.63
65.36
SrmSTRvStriatum ventral region73.38
46.78
SrmTHThalamus42.08
29.45
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001569 21 75 95 DEFSYQEMIANLPLCSHPNPR Peptide Atlas
SPEE_HUMAN_1 17 1 17 MEPGPDGPAASGPAAIR PRIDE
SPEE_HUMAN_135 13 135 147 FLPGMAIGYSSSK PRIDE
SPEE_HUMAN_149 13 149 161 LTLHVGDGFEFMK PRIDE
SPEE_HUMAN_194 24 194 217 TALKEDGVLCCQGECQWLHLDLIK PRIDE
SPEE_HUMAN_22 22 22 43 ETCSLWPGQALSLQVEQLLHHR PRIDE
SPEE_HUMAN_47 8 47 54 YQDILVFR PRIDE
SPEE_HUMAN_95 14 95 108 KVLIIGGGDGGVLR PRIDE
SPEE_HUMAN_96 13 96 108 VLIIGGGDGGVLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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