AutismKB 2.0

Annotation Detail for BRAF


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Basic Information Top
Gene Symbol:BRAF ( B-RAF1,BRAF1,FLJ95109,MGC126806,MGC138284,RAFB1 )
Gene Full Name: v-raf murine sarcoma viral oncogene homolog B1
Band: 7q34
Quick LinksEntrez ID:673; OMIM: 164757; Uniprot ID:BRAF_HUMAN; ENSEMBL ID: ENSG00000157764; HGNC ID: 1097
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus5 / 5640128
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult51 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor3 / 26384511
glioma20 / 106883187
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal50 / 336030714
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain30 / 110098927
cervix1 / 4817120
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine0 / 2344720 
kidney7 / 21177733
larynx1 / 2414541
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node6 / 9161065
mammary gland6 / 15327139
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta2 / 2808257
prostate6 / 18934531
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis13 / 33044239
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206044_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.65
Adipocyte8
AdrenalCortex10.1
Adrenalgland7.25
Amygdala9.1
Appendix18.05
AtrioventricularNode17.1
BDCA4+_DentriticCells6.8
Bonemarrow10.05
BronchialEpithelialCells7.2
CD105+_Endothelial8.7
CD14+_Monocytes8.85
CD19+_BCells(neg._sel.)8.25
CD33+_Myeloid10.3
CD34+8.7
CD4+_Tcells8.3
CD56+_NKCells9.15
CD71+_EarlyErythroid8.1
CD8+_Tcells7.75
CardiacMyocytes12.1
Caudatenucleus7.7
Cerebellum7
CerebellumPeduncles9.75
CiliaryGanglion7.45
CingulateCortex8.85
Colorectaladenocarcinoma8.2
DorsalRootGanglion10.55
FetalThyroid8.3
Fetalbrain7.8
Fetalliver9.7
Fetallung6.4
GlobusPallidus6.05
Heart15.9
Hypothalamus8.55
Kidney8.25
Leukemia_chronicMyelogenousK-5627.8
Leukemia_promyelocytic-HL-607.25
Leukemialymphoblastic(MOLT-4)6.9
Liver16.1
Lung9.2
Lymphnode7.6
Lymphoma_burkitts(Daudi)10.95
Lymphoma_burkitts(Raji)11.9
MedullaOblongata10.15
OccipitalLobe6.7
OlfactoryBulb6.9
Ovary7.3
Pancreas7.35
PancreaticIslet9.15
ParietalLobe9.2
Pituitary10.35
Placenta9.05
Pons9.6
PrefrontalCortex10.25
Prostate10.15
Salivarygland7.3
SkeletalMuscle12
Skin10.4
SmoothMuscle8.8
Spinalcord8.35
SubthalamicNucleus7.7
SuperiorCervicalGanglion34.65
TemporalLobe8.6
Testis14.5
TestisGermCell10.55
TestisIntersitial15.6
TestisLeydigCell16.4
TestisSeminiferousTubule9.85
Thalamus9.85
Thymus6.6
Thyroid9.2
Tongue12.15
Tonsil8.4
Trachea7.55
TrigeminalGanglion15.4
Uterus6.6
UterusCorpus11
WholeBlood9.05
Wholebrain6.7
colon8.65
pineal_day9.6
pineal_night9.86
retina11.175
small_intestine8.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P42935
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.32 ± 0.19
Basal Forebrain8.14 ± 0.08
Basal Part of Pons8.14 ± 0.28
Cerebellar Cortex8.35 ± 0.16
Cerebellar Nuclei7.9 ± 0.25
Claustrum8.4 ± 0.31
Epithalamus7.96 ± 0.19
Frontal Lobe8.05 ± 0.25
Globus Pallidus7.68 ± 0.14
Hypothalamus7.81 ± 0.18
Insula8.01 ± 0.2
Limbic Lobe8.32 ± 0.3
Mesencephalon8.11 ± 0.27
Myelencephalon8.1 ± 0.23
Occipital Lobe8.49 ± 0.3
Parietal Lobe8.25 ± 0.24
Pontine Tegmentum8.11 ± 0.28
Striatum8.25 ± 0.25
Subthalamus7.87 ± 0.2
Temporal Lobe8.06 ± 0.26
Thalamus8.04 ± 0.2
White Matter7.75 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
BrafCBCerebellum26.22
38.29
BrafCTXCerebral cortex91.58
79.45
BrafHIPHippocampal region69.91
100
BrafHPFHippocampal formation73.24
100
BrafHYHypothalamus18.94
16.63
BrafLSXLateral septal complex29.62
24.03
BrafMBMidbrain29.17
28.57
BrafMYMedulla33.02
39.57
BrafOLFOlfactory bulb63.66
59.81
BrafPPons24.44
28.57
BrafPALPallidum31.7
31.54
BrafRHPRetrohippocampal region78.97
74.6
BrafsAMYStriatum-like amygdalar nuclei38.92
31.55
BrafSTRStriatum60.4
50.57
BrafSTRdStriatum dorsal region59.51
49.4
BrafSTRvStriatum ventral region88.18
75.33
BrafTHThalamus49.01
48.28
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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