AutismKB 2.0

Annotation Detail for SRPK2


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Basic Information Top
Gene Symbol:SRPK2 ( FLJ36101,SFRSK2 )
Gene Full Name: SRSF protein kinase 2
Band: 7q22.3
Quick LinksEntrez ID:6733; OMIM: 602980; Uniprot ID:SRPK2_HUMAN; ENSEMBL ID: ENSG00000135250; HGNC ID: 11306
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst5 / 6231980
fetus56 / 56401299
neonate1 / 3109732
infant0 / 236200 
juvenile4 / 5555671
adult110 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor4 / 34366116
chondrosarcoma4 / 8282348
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor12 / 26384545
glioma4 / 10688337
head and neck tumor13 / 13630295
kidney tumor5 / 6895972
leukemia18 / 95842187
liver tumor3 / 9635931
lung tumor8 / 10312777
lymphoma3 / 7175541
non-neoplasia8 / 9725082
normal293 / 336030787
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer3 / 10268029
retinoblastoma4 / 4635686
skin tumor4 / 12494932
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood2 / 12347816
bone4 / 7165555
bone marrow4 / 4880181
brain180 / 1100989163
cervix6 / 48171124
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye14 / 21105466
heart5 / 8962655
intestine9 / 23447238
kidney7 / 21177733
larynx10 / 24145414
liver6 / 20774328
lung16 / 33697447
lymph0 / 442700 
lymph node3 / 9161032
mammary gland6 / 15327139
mouth3 / 6705244
muscle4 / 10771537
nerve1 / 1576863
ovary3 / 10205129
pancreas5 / 21481223
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta7 / 28082524
prostate4 / 18934521
salivary gland0 / 201550 
skin13 / 21057461
spleen3 / 5395255
stomach2 / 9661920
testis54 / 330442163
thymus7 / 8113186
thyroid6 / 47473126
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord1 / 1368073
uterus17 / 23287872
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203182_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts48.65
Adipocyte10.3
AdrenalCortex8.6
Adrenalgland6.6
Amygdala202.2
Appendix7.95
AtrioventricularNode5.8
BDCA4+_DentriticCells64.7
Bonemarrow5.7
BronchialEpithelialCells33.95
CD105+_Endothelial7.75
CD14+_Monocytes47.2
CD19+_BCells(neg._sel.)91.85
CD33+_Myeloid50.1
CD34+23.4
CD4+_Tcells66.3
CD56+_NKCells200.85
CD71+_EarlyErythroid4.45
CD8+_Tcells53.9
CardiacMyocytes15.05
Caudatenucleus41.45
Cerebellum14.1
CerebellumPeduncles30.2
CiliaryGanglion3.95
CingulateCortex94.25
Colorectaladenocarcinoma18.35
DorsalRootGanglion3.1
FetalThyroid7.65
Fetalbrain169.75
Fetalliver3.35
Fetallung8
GlobusPallidus39.4
Heart5.25
Hypothalamus159.4
Kidney3
Leukemia_chronicMyelogenousK-5629.8
Leukemia_promyelocytic-HL-608.9
Leukemialymphoblastic(MOLT-4)155.65
Liver6.15
Lung7.65
Lymphnode8.25
Lymphoma_burkitts(Daudi)14.15
Lymphoma_burkitts(Raji)10.7
MedullaOblongata76.45
OccipitalLobe132.75
OlfactoryBulb10.85
Ovary4.7
Pancreas6.25
PancreaticIslet12.3
ParietalLobe60.9
Pituitary16.2
Placenta5.25
Pons10.6
PrefrontalCortex285.9
Prostate13.2
Salivarygland5.9
SkeletalMuscle5.15
Skin6.85
SmoothMuscle24.3
Spinalcord39.45
SubthalamicNucleus62.65
SuperiorCervicalGanglion10.25
TemporalLobe56.7
Testis36.2
TestisGermCell99.65
TestisIntersitial71.45
TestisLeydigCell32.4
TestisSeminiferousTubule46.5
Thalamus95.25
Thymus18.85
Thyroid13.3
Tongue7.1
Tonsil8.25
Trachea9.4
TrigeminalGanglion9.7
Uterus20.15
UterusCorpus6.45
WholeBlood204.3
Wholebrain114.95
colon15
pineal_day53.34
pineal_night48.92
retina21.55
small_intestine14.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P215599
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.05 ± 0.3
Basal Forebrain9.17 ± 0.15
Basal Part of Pons9.29 ± 0.25
Cerebellar Cortex8.89 ± 0.22
Cerebellar Nuclei9.12 ± 0.26
Claustrum9.53 ± 0.36
Epithalamus8.68 ± 0.45
Frontal Lobe9.14 ± 0.29
Globus Pallidus8.98 ± 0.34
Hypothalamus9.1 ± 0.19
Insula9.1 ± 0.23
Limbic Lobe9.27 ± 0.33
Mesencephalon9.32 ± 0.38
Myelencephalon9.12 ± 0.3
Occipital Lobe9.49 ± 0.21
Parietal Lobe9.24 ± 0.28
Pontine Tegmentum9.16 ± 0.29
Striatum8.95 ± 0.37
Subthalamus9.43 ± 0.19
Temporal Lobe9.18 ± 0.26
Thalamus9.31 ± 0.25
White Matter9.4 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Srpk2CBCerebellum16.86
19.53
Srpk2CTXCerebral cortex100
100
Srpk2HIPHippocampal region39.86
62.02
Srpk2HPFHippocampal formation49.57
63.34
Srpk2HYHypothalamus12
10.48
Srpk2LSXLateral septal complex28.86
24.83
Srpk2MBMidbrain23.02
22.51
Srpk2MYMedulla22.13
26.77
Srpk2OLFOlfactory bulb52.02
56.24
Srpk2PPons19.55
23.18
Srpk2PALPallidum16.18
16.35
Srpk2RHPRetrohippocampal region67.92
68.34
Srpk2sAMYStriatum-like amygdalar nuclei26.42
21.44
Srpk2STRStriatum25.35
20.29
Srpk2STRdStriatum dorsal region25.73
20.43
Srpk2STRvStriatum ventral region24.56
18.94
Srpk2THThalamus58.59
59.17
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00025940 21 252 272 IIHTDIKPENILMCVDDAYVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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