AutismKB 2.0

Annotation Detail for SRPR


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Basic Information Top
Gene Symbol:SRPR ( DP,MGC17355,MGC3650,MGC9571,Sralpha )
Gene Full Name: signal recognition particle receptor (docking protein)
Band: 11q24.2
Quick LinksEntrez ID:6734; OMIM: 182180; Uniprot ID:SRPR_HUMAN; ENSEMBL ID: ENSG00000182934; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst11 / 62319176
fetus60 / 564012106
neonate6 / 31097192
infant0 / 236200 
juvenile4 / 5555671
adult343 / 1939121176
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma4 / 17475228
breast (mammary gland) tumor30 / 94178318
cervical tumor8 / 34366232
chondrosarcoma59 / 82823712
colorectal tumor27 / 114246236
esophageal tumor1 / 1729057
gastrointestinal tumor19 / 119369159
germ cell tumor18 / 26384568
glioma21 / 106883196
head and neck tumor19 / 136302139
kidney tumor17 / 68959246
leukemia21 / 95842219
liver tumor8 / 9635983
lung tumor5 / 10312748
lymphoma9 / 71755125
non-neoplasia11 / 97250113
normal424 / 3360307126
ovarian tumor24 / 76682312
pancreatic tumor26 / 104616248
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer5 / 10268048
retinoblastoma5 / 46356107
skin tumor17 / 124949136
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland8 / 33197240
ascites5 / 40015124
bladder4 / 29757134
blood15 / 123478121
bone26 / 71655362
bone marrow7 / 48801143
brain100 / 110098990
cervix13 / 48171269
connective tissue27 / 149255180
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus1 / 2020949
eye22 / 211054104
heart13 / 89626145
intestine41 / 234472174
kidney36 / 211777169
larynx1 / 2414541
liver16 / 20774377
lung56 / 336974166
lymph4 / 4427090
lymph node16 / 91610174
mammary gland47 / 153271306
mouth8 / 67052119
muscle24 / 107715222
nerve2 / 15768126
ovary25 / 102051244
pancreas53 / 214812246
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta27 / 28082596
prostate18 / 18934595
salivary gland1 / 2015549
skin53 / 210574251
spleen6 / 53952111
stomach11 / 96619113
testis30 / 33044290
thymus25 / 81131308
thyroid14 / 47473294
tonsil1 / 1699958
trachea7 / 52413133
umbilical cord0 / 136800 
uterus18 / 23287877
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200918_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts381.25
Adipocyte62.65
AdrenalCortex41.4
Adrenalgland106.25
Amygdala53
Appendix31.05
AtrioventricularNode18.25
BDCA4+_DentriticCells688.3
Bonemarrow101.2
BronchialEpithelialCells193.75
CD105+_Endothelial163.3
CD14+_Monocytes236.85
CD19+_BCells(neg._sel.)210.6
CD33+_Myeloid331.6
CD34+309.25
CD4+_Tcells256.95
CD56+_NKCells361.7
CD71+_EarlyErythroid75.1
CD8+_Tcells344.35
CardiacMyocytes56.5
Caudatenucleus30.6
Cerebellum34.65
CerebellumPeduncles29.95
CiliaryGanglion23.25
CingulateCortex35.65
Colorectaladenocarcinoma150.85
DorsalRootGanglion23.55
FetalThyroid114.65
Fetalbrain19.85
Fetalliver68.7
Fetallung103.4
GlobusPallidus21.85
Heart75.25
Hypothalamus56.95
Kidney58.85
Leukemia_chronicMyelogenousK-562219.25
Leukemia_promyelocytic-HL-6076.85
Leukemialymphoblastic(MOLT-4)92.05
Liver345.55
Lung210.7
Lymphnode121.85
Lymphoma_burkitts(Daudi)88.75
Lymphoma_burkitts(Raji)86.95
MedullaOblongata33.1
OccipitalLobe34.1
OlfactoryBulb64
Ovary66.8
Pancreas156.8
PancreaticIslet601.5
ParietalLobe27.4
Pituitary227.05
Placenta205.35
Pons30.75
PrefrontalCortex71.95
Prostate257.75
Salivarygland179.1
SkeletalMuscle32.65
Skin22.85
SmoothMuscle203.25
Spinalcord47.3
SubthalamicNucleus22.65
SuperiorCervicalGanglion33.6
TemporalLobe26.8
Testis49.45
TestisGermCell64.9
TestisIntersitial31.55
TestisLeydigCell43.05
TestisSeminiferousTubule36.6
Thalamus45.15
Thymus119.35
Thyroid192.35
Tongue27.3
Tonsil113.15
Trachea282.25
TrigeminalGanglion32.1
Uterus88.85
UterusCorpus30.25
WholeBlood241.7
Wholebrain96.4
colon98.05
pineal_day143.4
pineal_night157.52
retina260.325
small_intestine151.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P86943
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.63 ± 0.35
Basal Forebrain6.37 ± 0.11
Basal Part of Pons7.05 ± 0.18
Cerebellar Cortex6.57 ± 0.23
Cerebellar Nuclei6.89 ± 0.29
Claustrum6.76 ± 0.17
Epithalamus6.36 ± 0.21
Frontal Lobe6.79 ± 0.28
Globus Pallidus6.26 ± 0.24
Hypothalamus6.53 ± 0.33
Insula6.65 ± 0.15
Limbic Lobe6.65 ± 0.25
Mesencephalon6.66 ± 0.29
Myelencephalon6.64 ± 0.29
Occipital Lobe6.69 ± 0.18
Parietal Lobe6.75 ± 0.27
Pontine Tegmentum6.63 ± 0.23
Striatum6.53 ± 0.27
Subthalamus6.92 ± 0.27
Temporal Lobe6.65 ± 0.23
Thalamus6.76 ± 0.21
White Matter6.55 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SrprCBCerebellum18.28
15.85
SrprCTXCerebral cortex9.75
6.01
SrprHIPHippocampal region31.19
16.45
SrprHPFHippocampal formation25.51
13.56
SrprHYHypothalamus8.29
5.08
SrprLSXLateral septal complex8.58
4.72
SrprMBMidbrain7.63
5.66
SrprMYMedulla15.07
13.02
SrprOLFOlfactory bulb15.81
9.27
SrprPPons13.3
11.12
SrprPALPallidum6.36
4.07
SrprRHPRetrohippocampal region14.86
9.09
SrprsAMYStriatum-like amygdalar nuclei4.19
2.68
SrprSTRStriatum7.64
4.06
SrprSTRdStriatum dorsal region7.49
3.98
SrprSTRvStriatum ventral region10.68
5.23
SrprTHThalamus6.1
3.44
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003134 32 283 314 GTGSGGQLQDLDCSSSDDEGAAQNSTKPSATK Peptide Atlas
SRPR_HUMAN_387 15 387 401 QALQESLVQILQPQR PRIDE
SRPR_HUMAN_485 8 485 492 TMVQLFEK PRIDE
SRPR_HUMAN_497 14 497 510 DAAGIAMEAIAFAR PRIDE
SRPR_HUMAN_569 12 569 580 ALADHSMAQTPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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