AutismKB 2.0

Annotation Detail for SSB


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Basic Information Top
Gene Symbol:SSB ( LARP3,La )
Gene Full Name: Sjogren syndrome antigen B (autoantigen La)
Band: 2q31.1
Quick LinksEntrez ID:6741; OMIM: 109090; Uniprot ID:LA_HUMAN; ENSEMBL ID: ENSG00000138385; HGNC ID: 11316
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst11 / 62319176
fetus41 / 56401272
neonate1 / 3109732
infant2 / 2362084
juvenile0 / 555560 
adult164 / 193912184
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma8 / 17475457
breast (mammary gland) tumor12 / 94178127
cervical tumor1 / 3436629
chondrosarcoma9 / 82823108
colorectal tumor9 / 11424678
esophageal tumor1 / 1729057
gastrointestinal tumor25 / 119369209
germ cell tumor26 / 26384598
glioma10 / 10688393
head and neck tumor10 / 13630273
kidney tumor3 / 6895943
leukemia27 / 95842281
liver tumor13 / 96359134
lung tumor6 / 10312758
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal277 / 336030782
ovarian tumor6 / 7668278
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer7 / 10268068
retinoblastoma2 / 4635643
skin tumor13 / 124949104
soft tissue/muscle tissue tumor20 / 125191159
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites5 / 40015124
bladder10 / 29757336
blood8 / 12347864
bone11 / 71655153
bone marrow29 / 48801594
brain80 / 110098972
cervix2 / 4817141
connective tissue9 / 14925560
ear2 / 16212123
embryonic tissue38 / 215722176
esophagus1 / 2020949
eye13 / 21105461
heart4 / 8962644
intestine18 / 23447276
kidney15 / 21177770
larynx2 / 2414582
liver26 / 207743125
lung33 / 33697497
lymph1 / 4427022
lymph node9 / 9161098
mammary gland16 / 153271104
mouth4 / 6705259
muscle9 / 10771583
nerve0 / 157680 
ovary9 / 10205188
pancreas15 / 21481269
parathyroid1 / 2053948
pharynx8 / 41328193
pituitary gland4 / 16585241
placenta20 / 28082571
prostate16 / 18934584
salivary gland8 / 20155396
skin17 / 21057480
spleen2 / 5395237
stomach17 / 96619175
testis40 / 330442121
thymus3 / 8113136
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus27 / 232878115
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201139_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts763.55
Adipocyte207.2
AdrenalCortex65.85
Adrenalgland30.15
Amygdala211.35
Appendix54.35
AtrioventricularNode76.45
BDCA4+_DentriticCells127.1
Bonemarrow49.3
BronchialEpithelialCells165.55
CD105+_Endothelial301.85
CD14+_Monocytes118.6
CD19+_BCells(neg._sel.)258.15
CD33+_Myeloid134.75
CD34+510.75
CD4+_Tcells183.55
CD56+_NKCells138.35
CD71+_EarlyErythroid187.05
CD8+_Tcells193.3
CardiacMyocytes320.45
Caudatenucleus71.85
Cerebellum44.65
CerebellumPeduncles74.05
CiliaryGanglion57.8
CingulateCortex96.5
Colorectaladenocarcinoma494.8
DorsalRootGanglion57.75
FetalThyroid112.65
Fetalbrain99.55
Fetalliver126
Fetallung129.65
GlobusPallidus54.35
Heart97.25
Hypothalamus241.55
Kidney32.8
Leukemia_chronicMyelogenousK-562334.5
Leukemia_promyelocytic-HL-60495.8
Leukemialymphoblastic(MOLT-4)197
Liver60.8
Lung30.85
Lymphnode157.25
Lymphoma_burkitts(Daudi)534.2
Lymphoma_burkitts(Raji)489.6
MedullaOblongata94.95
OccipitalLobe108.25
OlfactoryBulb85.45
Ovary50.7
Pancreas155.35
PancreaticIslet161.1
ParietalLobe111.7
Pituitary131.75
Placenta27.45
Pons62.5
PrefrontalCortex168.15
Prostate63
Salivarygland50.8
SkeletalMuscle101.1
Skin56.4
SmoothMuscle284
Spinalcord43.65
SubthalamicNucleus93.7
SuperiorCervicalGanglion74.25
TemporalLobe53.8
Testis28.55
TestisGermCell68.3
TestisIntersitial47.25
TestisLeydigCell63.3
TestisSeminiferousTubule67.2
Thalamus125.3
Thymus33.4
Thyroid324.7
Tongue76.4
Tonsil137.25
Trachea49.1
TrigeminalGanglion71.85
Uterus159.1
UterusCorpus70.1
WholeBlood182.55
Wholebrain71.35
colon48.95
pineal_day377.94
pineal_night316.94
retina54.325
small_intestine26.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3244_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.57 ± 0.59
Basal Forebrain6.64 ± 0.29
Basal Part of Pons7.09 ± 0.48
Cerebellar Cortex6.81 ± 0.41
Cerebellar Nuclei6.74 ± 0.32
Claustrum6.68 ± 0.41
Epithalamus7.33 ± 0.49
Frontal Lobe6.9 ± 0.55
Globus Pallidus6.57 ± 0.25
Hypothalamus7.06 ± 0.5
Insula7.01 ± 0.65
Limbic Lobe6.7 ± 0.59
Mesencephalon6.63 ± 0.56
Myelencephalon6.7 ± 0.54
Occipital Lobe6.61 ± 0.61
Parietal Lobe6.82 ± 0.44
Pontine Tegmentum6.72 ± 0.48
Striatum6.58 ± 0.55
Subthalamus6.17 ± 1.21
Temporal Lobe6.74 ± 0.46
Thalamus6.75 ± 0.37
White Matter6.39 ± 0.65
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SsbCBCerebellum46.5
63.14
SsbCTXCerebral cortex100
94.68
SsbHIPHippocampal region79.23
100
SsbHPFHippocampal formation87.83
100
SsbHYHypothalamus56.31
48.4
SsbLSXLateral septal complex75.41
63.19
SsbMBMidbrain63.53
61
SsbMYMedulla48.11
56.43
SsbOLFOlfactory bulb96.55
100
SsbPPons44.71
52.02
SsbPALPallidum51.17
52.29
SsbRHPRetrohippocampal region100
100
SsbsAMYStriatum-like amygdalar nuclei69.7
56.84
SsbSTRStriatum67.31
54.5
SsbSTRdStriatum dorsal region66.67
54.92
SsbSTRvStriatum ventral region68.2
51.26
SsbTHThalamus64.88
63.07
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LA_HUMAN_116 27 116 142 GFPTDATLDDIKEWLEDKGQVLNIQMR PRIDE
LA_HUMAN_135 9 135 143 GQVLNIQMR PRIDE
LA_HUMAN_151 14 151 164 GSIFVVFDSIESAK PRIDE
LA_HUMAN_16 16 16 31 ICHQIEYYFGDFNLPR PRIDE
LA_HUMAN_174 17 174 190 YKETDLLILFKDDYFAK PRIDE
LA_HUMAN_176 15 176 190 ETDLLILFKDDYFAK PRIDE
LA_HUMAN_215 10 215 224 QKLEEDAEMK PRIDE
LA_HUMAN_235 25 235 259 FSGDLDDQTCREDLHILFSNHGEIK PRIDE
LA_HUMAN_317 11 317 327 IIEDQQESLNK PRIDE
LA_HUMAN_37 17 37 53 EQIKLDEGWVPLEIMIK PRIDE
LA_HUMAN_42 13 42 54 LDEGWVPLEIMIK PRIDE
LA_HUMAN_60 14 60 73 LTTDFNVIVEALSK PRIDE
LA_HUMAN_74 14 74 87 SKAELMEISEDKTK PRIDE
LA_HUMAN_90 19 90 108 RSPSKPLPEVTDEYKNDVK PRIDE
PAp00002571 11 236 246 FSGDLDDQTCR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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