AutismKB 2.0

Annotation Detail for SSR2


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Basic Information Top
Gene Symbol:SSR2 ( DKFZp686F19123,TLAP,TRAP-BETA,TRAPB )
Gene Full Name: signal sequence receptor, beta (translocon-associated protein beta)
Band: 1q22
Quick LinksEntrez ID:6746; OMIM: 600867; Uniprot ID:SSRB_HUMAN; ENSEMBL ID: ENSG00000163479; HGNC ID: 11324
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body31 / 70761438
blastocyst17 / 62319272
fetus68 / 564012120
neonate6 / 31097192
infant2 / 2362084
juvenile6 / 55556107
adult299 / 1939121154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma1 / 1747557
breast (mammary gland) tumor15 / 94178159
cervical tumor7 / 34366203
chondrosarcoma20 / 82823241
colorectal tumor24 / 114246210
esophageal tumor10 / 17290578
gastrointestinal tumor30 / 119369251
germ cell tumor38 / 263845144
glioma13 / 106883121
head and neck tumor11 / 13630280
kidney tumor17 / 68959246
leukemia18 / 95842187
liver tumor33 / 96359342
lung tumor44 / 103127426
lymphoma13 / 71755181
non-neoplasia6 / 9725061
normal495 / 3360307147
ovarian tumor37 / 76682482
pancreatic tumor19 / 104616181
primitive neuroectodermal tumor of the CNS37 / 125680294
prostate cancer40 / 102680389
retinoblastoma18 / 46356388
skin tumor36 / 124949288
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland8 / 33197240
ascites7 / 40015174
bladder1 / 2975733
blood27 / 123478218
bone21 / 71655293
bone marrow17 / 48801348
brain126 / 1100989114
cervix8 / 48171166
connective tissue17 / 149255113
ear1 / 1621261
embryonic tissue71 / 215722329
esophagus10 / 20209494
eye45 / 211054213
heart18 / 89626200
intestine41 / 234472174
kidney35 / 211777165
larynx1 / 2414541
liver49 / 207743235
lung89 / 336974264
lymph8 / 44270180
lymph node10 / 91610109
mammary gland20 / 153271130
mouth2 / 6705229
muscle22 / 107715204
nerve2 / 15768126
ovary42 / 102051411
pancreas64 / 214812297
parathyroid3 / 20539146
pharynx9 / 41328217
pituitary gland1 / 1658560
placenta43 / 280825153
prostate58 / 189345306
salivary gland5 / 20155248
skin49 / 210574232
spleen3 / 5395255
stomach24 / 96619248
testis29 / 33044287
thymus8 / 8113198
thyroid6 / 47473126
tonsil3 / 16999176
trachea4 / 5241376
umbilical cord6 / 13680438
uterus27 / 232878115
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200652_at
Cell line Expression level Expression bar
721_B_lymphoblasts667.9
Adipocyte301.6
AdrenalCortex368.95
Adrenalgland487.85
Amygdala70.5
Appendix158.55
AtrioventricularNode17.75
BDCA4+_DentriticCells1159.65
Bonemarrow277.4
BronchialEpithelialCells738.25
CD105+_Endothelial222.95
CD14+_Monocytes917.1
CD19+_BCells(neg._sel.)1228.7
CD33+_Myeloid840.3
CD34+902.85
CD4+_Tcells904.4
CD56+_NKCells1241.4
CD71+_EarlyErythroid63.75
CD8+_Tcells815.1
CardiacMyocytes575.9
Caudatenucleus73.4
Cerebellum139.55
CerebellumPeduncles136
CiliaryGanglion59.9
CingulateCortex64.85
Colorectaladenocarcinoma74.15
DorsalRootGanglion80.6
FetalThyroid244.4
Fetalbrain263.85
Fetalliver145.15
Fetallung461.5
GlobusPallidus44.9
Heart237.6
Hypothalamus101.35
Kidney272.6
Leukemia_chronicMyelogenousK-562304.65
Leukemia_promyelocytic-HL-60191.8
Leukemialymphoblastic(MOLT-4)208.75
Liver310.25
Lung418.95
Lymphnode377.25
Lymphoma_burkitts(Daudi)411.35
Lymphoma_burkitts(Raji)271.45
MedullaOblongata85.6
OccipitalLobe73.95
OlfactoryBulb180
Ovary388.95
Pancreas355.7
PancreaticIslet660.6
ParietalLobe62.9
Pituitary268.5
Placenta402.7
Pons79.5
PrefrontalCortex143
Prostate197.7
Salivarygland260.75
SkeletalMuscle60.05
Skin40.05
SmoothMuscle980.1
Spinalcord131.95
SubthalamicNucleus46.75
SuperiorCervicalGanglion29.35
TemporalLobe100.65
Testis362.75
TestisGermCell273.1
TestisIntersitial253.35
TestisLeydigCell285.55
TestisSeminiferousTubule215.55
Thalamus113.15
Thymus527.1
Thyroid275.55
Tongue71.65
Tonsil291.3
Trachea258.8
TrigeminalGanglion31.65
Uterus261.15
UterusCorpus325.45
WholeBlood686.35
Wholebrain142.6
colon299.85
pineal_day112.34
pineal_night135.52
retina215.4
small_intestine520.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P282578
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.22 ± 0.21
Basal Forebrain7.53 ± 0.18
Basal Part of Pons7.64 ± 0.27
Cerebellar Cortex7.47 ± 0.3
Cerebellar Nuclei7.6 ± 0.26
Claustrum7.23 ± 0.28
Epithalamus7.49 ± 0.26
Frontal Lobe7.52 ± 0.3
Globus Pallidus7.52 ± 0.23
Hypothalamus7.65 ± 0.37
Insula7.49 ± 0.25
Limbic Lobe7.3 ± 0.31
Mesencephalon7.33 ± 0.34
Myelencephalon7.44 ± 0.32
Occipital Lobe7.21 ± 0.28
Parietal Lobe7.39 ± 0.29
Pontine Tegmentum7.38 ± 0.29
Striatum7.5 ± 0.26
Subthalamus7.65 ± 0.33
Temporal Lobe7.43 ± 0.31
Thalamus7.47 ± 0.21
White Matter7.61 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ssr2CBCerebellum38.64
61.09
Ssr2CTXCerebral cortex100
83.42
Ssr2HIPHippocampal region60.66
98.08
Ssr2HPFHippocampal formation77.23
89.65
Ssr2HYHypothalamus82.05
67.8
Ssr2LSXLateral septal complex75.08
60.58
Ssr2MBMidbrain65.52
59.43
Ssr2MYMedulla67.88
75.37
Ssr2OLFOlfactory bulb100
87.27
Ssr2PPons76.17
76.13
Ssr2PALPallidum77.17
67.91
Ssr2RHPRetrohippocampal region96.5
80.91
Ssr2sAMYStriatum-like amygdalar nuclei88.34
68.25
Ssr2STRStriatum74.7
51.49
Ssr2STRdStriatum dorsal region67.37
46.33
Ssr2STRvStriatum ventral region84.76
53.78
Ssr2THThalamus79.22
64.99
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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