AutismKB 2.0

Annotation Detail for SSR4


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Basic Information Top
Gene Symbol:SSR4 ( TRAPD )
Gene Full Name: signal sequence receptor, delta (translocon-associated protein delta)
Band: Xq28
Quick LinksEntrez ID:6748; OMIM: 300090; Uniprot ID:SSRD_HUMAN; ENSEMBL ID: ENSG00000180879; HGNC ID: 11326
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst16 / 62319256
fetus62 / 564012109
neonate3 / 3109796
infant3 / 23620127
juvenile1 / 5555617
adult245 / 1939121126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor6 / 9417863
cervical tumor4 / 34366116
chondrosarcoma13 / 82823156
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor26 / 119369217
germ cell tumor24 / 26384590
glioma11 / 106883102
head and neck tumor3 / 13630222
kidney tumor7 / 68959101
leukemia12 / 95842125
liver tumor17 / 96359176
lung tumor13 / 103127126
lymphoma3 / 7175541
non-neoplasia5 / 9725051
normal382 / 3360307113
ovarian tumor10 / 76682130
pancreatic tumor43 / 104616411
primitive neuroectodermal tumor of the CNS19 / 125680151
prostate cancer23 / 102680223
retinoblastoma5 / 46356107
skin tumor22 / 124949176
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland8 / 33197240
ascites8 / 40015199
bladder3 / 29757100
blood15 / 123478121
bone6 / 7165583
bone marrow12 / 48801245
brain62 / 110098956
cervix5 / 48171103
connective tissue12 / 14925580
ear0 / 162120 
embryonic tissue40 / 215722185
esophagus0 / 202090 
eye16 / 21105475
heart14 / 89626156
intestine35 / 234472149
kidney17 / 21177780
larynx0 / 241450 
liver27 / 207743129
lung48 / 336974142
lymph1 / 4427022
lymph node21 / 91610229
mammary gland9 / 15327158
mouth2 / 6705229
muscle6 / 10771555
nerve0 / 157680 
ovary14 / 102051137
pancreas50 / 214812232
parathyroid9 / 20539438
pharynx2 / 4132848
pituitary gland6 / 16585361
placenta35 / 280825124
prostate49 / 189345258
salivary gland3 / 20155148
skin32 / 210574151
spleen12 / 53952222
stomach12 / 96619124
testis21 / 33044263
thymus4 / 8113149
thyroid2 / 4747342
tonsil3 / 16999176
trachea2 / 5241338
umbilical cord3 / 13680219
uterus15 / 23287864
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201004_at
Cell line Expression level Expression bar
721_B_lymphoblasts781.7
Adipocyte765.6
AdrenalCortex524.15
Adrenalgland930.7
Amygdala280.1
Appendix270.35
AtrioventricularNode63.7
BDCA4+_DentriticCells2968.65
Bonemarrow1239.1
BronchialEpithelialCells1107.4
CD105+_Endothelial854.6
CD14+_Monocytes1253.15
CD19+_BCells(neg._sel.)1549.45
CD33+_Myeloid1181.45
CD34+1711.9
CD4+_Tcells1075.1
CD56+_NKCells1751.95
CD71+_EarlyErythroid365.35
CD8+_Tcells1090.6
CardiacMyocytes873.05
Caudatenucleus251.7
Cerebellum266.35
CerebellumPeduncles265.45
CiliaryGanglion61.4
CingulateCortex149.05
Colorectaladenocarcinoma1220.75
DorsalRootGanglion116.15
FetalThyroid856.15
Fetalbrain273.75
Fetalliver438.4
Fetallung946.75
GlobusPallidus79.55
Heart2664.9
Hypothalamus509.05
Kidney378.25
Leukemia_chronicMyelogenousK-562542.95
Leukemia_promyelocytic-HL-60527.55
Leukemialymphoblastic(MOLT-4)561.25
Liver3609.05
Lung1687.4
Lymphnode1898.2
Lymphoma_burkitts(Daudi)1108.25
Lymphoma_burkitts(Raji)993.95
MedullaOblongata150.2
OccipitalLobe201.55
OlfactoryBulb308.75
Ovary505.8
Pancreas2695.05
PancreaticIslet2612.35
ParietalLobe202.65
Pituitary2770.45
Placenta1591.4
Pons112.4
PrefrontalCortex258.75
Prostate2549.65
Salivarygland1119.4
SkeletalMuscle39.3
Skin117.1
SmoothMuscle1599.55
Spinalcord402
SubthalamicNucleus141.6
SuperiorCervicalGanglion34.1
TemporalLobe165.4
Testis677.9
TestisGermCell620.25
TestisIntersitial336.9
TestisLeydigCell498.7
TestisSeminiferousTubule400.95
Thalamus287.6
Thymus1362.9
Thyroid1517.45
Tongue321.8
Tonsil1249.5
Trachea2225.1
TrigeminalGanglion67
Uterus1020.8
UterusCorpus524.35
WholeBlood744.8
Wholebrain853.7
colon842.55
pineal_day1545.62
pineal_night1875.38
retina704.1
small_intestine1489.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P259172
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.36 ± 0.29
Basal Forebrain9.63 ± 0.2
Basal Part of Pons9.59 ± 0.35
Cerebellar Cortex9.47 ± 0.29
Cerebellar Nuclei9.81 ± 0.24
Claustrum9.34 ± 0.45
Epithalamus10.13 ± 0.14
Frontal Lobe9.73 ± 0.3
Globus Pallidus10.27 ± 0.34
Hypothalamus10.22 ± 0.36
Insula9.72 ± 0.33
Limbic Lobe9.44 ± 0.43
Mesencephalon9.6 ± 0.37
Myelencephalon9.63 ± 0.3
Occipital Lobe9.11 ± 0.39
Parietal Lobe9.54 ± 0.29
Pontine Tegmentum9.7 ± 0.3
Striatum9.66 ± 0.22
Subthalamus9.67 ± 0.24
Temporal Lobe9.7 ± 0.32
Thalamus9.62 ± 0.24
White Matter10.41 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ssr4CBCerebellum34.82
49.08
Ssr4CTXCerebral cortex86.04
70.45
Ssr4HIPHippocampal region44
56.8
Ssr4HPFHippocampal formation56.61
60.5
Ssr4HYHypothalamus58.49
55.95
Ssr4LSXLateral septal complex40.56
27.04
Ssr4MBMidbrain40.95
38.89
Ssr4MYMedulla41.29
46.9
Ssr4OLFOlfactory bulb69.74
61.94
Ssr4PPons39.05
43.4
Ssr4PALPallidum49.65
46.78
Ssr4RHPRetrohippocampal region74.8
64.35
Ssr4sAMYStriatum-like amygdalar nuclei71.14
55.98
Ssr4STRStriatum55.63
42.78
Ssr4STRdStriatum dorsal region53.9
41.71
Ssr4STRvStriatum ventral region56.67
42.2
Ssr4THThalamus52.88
47.04
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00005900 19 121 139 NNEDISIIPPLFTVSVDHR Peptide Atlas
SSRD_HUMAN_0 0 0 0 FFDEESYSLLR PRIDE
SSRD_HUMAN_0 0 0 0 NNEDISIIPPLFTVSVDHR PRIDE
SSRD_HUMAN_105 11 105 115 FFDEESYSLLR PRIDE
SSRD_HUMAN_106 11 106 116 FFDEESYSLLR PRIDE
SSRD_HUMAN_120 19 120 138 NNEDISIIPPLFTVSVDHR PRIDE
SSRD_HUMAN_60 13 60 72 VQNMALYADVGGK PRIDE
SSRD_HUMAN_61 13 61 73 VQNMALYADVGGK PRIDE
SSRD_HUMAN_96 10 96 105 SAHAGTYEVR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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