AutismKB 2.0

Annotation Detail for STAT2


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Basic Information Top
Gene Symbol:STAT2 ( ISGF-3,MGC59816,P113,STAT113 )
Gene Full Name: signal transducer and activator of transcription 2, 113kDa
Band: 12q13.2
Quick LinksEntrez ID:6773; OMIM: 600556; Uniprot ID:STAT2_HUMAN; ENSEMBL ID: ENSG00000170581; HGNC ID: 11363
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus12 / 56401221
neonate6 / 31097192
infant0 / 236200 
juvenile2 / 5555635
adult112 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma12 / 82823144
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor11 / 26384541
glioma3 / 10688328
head and neck tumor18 / 136302132
kidney tumor8 / 68959116
leukemia9 / 9584293
liver tumor1 / 9635910
lung tumor8 / 10312777
lymphoma3 / 7175541
non-neoplasia1 / 9725010
normal176 / 336030752
ovarian tumor5 / 7668265
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder3 / 29757100
blood11 / 12347889
bone6 / 7165583
bone marrow1 / 4880120
brain86 / 110098978
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye6 / 21105428
heart2 / 8962622
intestine12 / 23447251
kidney9 / 21177742
larynx2 / 2414582
liver2 / 2077439
lung25 / 33697474
lymph0 / 442700 
lymph node8 / 9161087
mammary gland8 / 15327152
mouth13 / 67052193
muscle6 / 10771555
nerve2 / 15768126
ovary9 / 10205188
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta6 / 28082521
prostate11 / 18934558
salivary gland0 / 201550 
skin9 / 21057442
spleen3 / 5395255
stomach2 / 9661920
testis12 / 33044236
thymus7 / 8113186
thyroid8 / 47473168
tonsil1 / 1699958
trachea16 / 52413305
umbilical cord4 / 13680292
uterus22 / 23287894
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205170_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.5
Adipocyte5
AdrenalCortex4.9
Adrenalgland3.8
Amygdala4.6
Appendix4.6
AtrioventricularNode3.8
BDCA4+_DentriticCells43.8
Bonemarrow4.45
BronchialEpithelialCells4.4
CD105+_Endothelial4.5
CD14+_Monocytes7.5
CD19+_BCells(neg._sel.)5.15
CD33+_Myeloid18.7
CD34+5.8
CD4+_Tcells9.3
CD56+_NKCells8.65
CD71+_EarlyErythroid4.2
CD8+_Tcells7.2
CardiacMyocytes6.4
Caudatenucleus4
Cerebellum3.65
CerebellumPeduncles5.1
CiliaryGanglion3.25
CingulateCortex4.65
Colorectaladenocarcinoma4.55
DorsalRootGanglion3.65
FetalThyroid4.4
Fetalbrain4.5
Fetalliver3.95
Fetallung3.7
GlobusPallidus3.4
Heart5.85
Hypothalamus4.75
Kidney3.65
Leukemia_chronicMyelogenousK-5624
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)3.6
Liver6.05
Lung4.95
Lymphnode3.9
Lymphoma_burkitts(Daudi)5.7
Lymphoma_burkitts(Raji)6.45
MedullaOblongata4.1
OccipitalLobe4
OlfactoryBulb3.6
Ovary3
Pancreas3.65
PancreaticIslet4.75
ParietalLobe4.8
Pituitary5.2
Placenta4.6
Pons4.3
PrefrontalCortex5.4
Prostate5.25
Salivarygland3.7
SkeletalMuscle5.45
Skin6
SmoothMuscle5.1
Spinalcord4.8
SubthalamicNucleus4.15
SuperiorCervicalGanglion13.4
TemporalLobe4.15
Testis3.8
TestisGermCell3.75
TestisIntersitial3.75
TestisLeydigCell4.5
TestisSeminiferousTubule3.9
Thalamus4.55
Thymus3.7
Thyroid5.55
Tongue4.5
Tonsil4.35
Trachea3.75
TrigeminalGanglion4.9
Uterus3.65
UterusCorpus4
WholeBlood4.95
Wholebrain3.6
colon4.45
pineal_day5.72
pineal_night5.44
retina5.475
small_intestine4.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P76090
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.36 ± 0.74
Basal Forebrain3.05 ± 0.49
Basal Part of Pons2.97 ± 0.46
Cerebellar Cortex3.65 ± 0.42
Cerebellar Nuclei3.37 ± 0.44
Claustrum3.34 ± 0.69
Epithalamus3.03 ± 0.66
Frontal Lobe3.29 ± 0.58
Globus Pallidus3.8 ± 0.84
Hypothalamus2.99 ± 0.75
Insula3.28 ± 0.47
Limbic Lobe3.32 ± 0.63
Mesencephalon3.34 ± 0.64
Myelencephalon3.31 ± 0.61
Occipital Lobe3.1 ± 0.65
Parietal Lobe3.3 ± 0.65
Pontine Tegmentum3.26 ± 0.7
Striatum2.83 ± 0.58
Subthalamus3.16 ± 0.72
Temporal Lobe3.29 ± 0.67
Thalamus3.19 ± 0.58
White Matter4.82 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Stat2CBCerebellum9.51
10.09
Stat2CTXCerebral cortex2.26
1.77
Stat2HIPHippocampal region5.35
5.23
Stat2HPFHippocampal formation4.48
4.07
Stat2HYHypothalamus0.43
0.34
Stat2LSXLateral septal complex0.7
0.91
Stat2MBMidbrain1.15
1.58
Stat2MYMedulla4.68
5.12
Stat2OLFOlfactory bulb4.55
4.22
Stat2PPons2.95
3.05
Stat2PALPallidum0.71
0.65
Stat2RHPRetrohippocampal region3.72
2.97
Stat2sAMYStriatum-like amygdalar nuclei1.34
1.55
Stat2STRStriatum1.41
1.09
Stat2STRdStriatum dorsal region1.24
0.82
Stat2STRvStriatum ventral region2.31
1.72
Stat2THThalamus1.91
1.52
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024519 15 74 88 CSQDPESLLLQHNLR Peptide Atlas
STAT2_HUMAN_797 11 797 807 HLNTEPMEIFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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