AutismKB 2.0

Annotation Detail for STK4


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Basic Information Top
Gene Symbol:STK4 ( DKFZp686A2068,KRS2,MST1,YSK3 )
Gene Full Name: serine/threonine kinase 4
Band: 20q13.12
Quick LinksEntrez ID:6789; OMIM: 604965; Uniprot ID:STK4_HUMAN; ENSEMBL ID: ENSG00000101109; HGNC ID: 11408
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult90 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor4 / 11936933
germ cell tumor9 / 26384534
glioma3 / 10688328
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia19 / 95842198
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia4 / 9725041
normal115 / 336030734
ovarian tumor5 / 7668265
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood17 / 123478137
bone2 / 7165527
bone marrow4 / 4880181
brain22 / 110098919
cervix3 / 4817162
connective tissue3 / 14925520
ear2 / 16212123
embryonic tissue6 / 21572227
esophagus2 / 2020998
eye6 / 21105428
heart0 / 896260 
intestine10 / 23447242
kidney4 / 21177718
larynx0 / 241450 
liver4 / 20774319
lung12 / 33697435
lymph2 / 4427045
lymph node23 / 91610251
mammary gland6 / 15327139
mouth1 / 6705214
muscle8 / 10771574
nerve0 / 157680 
ovary5 / 10205148
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta2 / 2808257
prostate7 / 18934536
salivary gland1 / 2015549
skin11 / 21057452
spleen0 / 539520 
stomach3 / 9661931
testis5 / 33044215
thymus8 / 8113198
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus4 / 23287817
vascular3 / 5178057
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205411_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.7
Adipocyte4.45
AdrenalCortex4.65
Adrenalgland3.85
Amygdala4.65
Appendix4.85
AtrioventricularNode3.85
BDCA4+_DentriticCells5.05
Bonemarrow4.4
BronchialEpithelialCells4.4
CD105+_Endothelial4.5
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)4.9
CD33+_Myeloid6.45
CD34+5.65
CD4+_Tcells9.25
CD56+_NKCells7.4
CD71+_EarlyErythroid4.25
CD8+_Tcells9.15
CardiacMyocytes6.2
Caudatenucleus4
Cerebellum3.65
CerebellumPeduncles5.2
CiliaryGanglion3.45
CingulateCortex4.65
Colorectaladenocarcinoma4.5
DorsalRootGanglion3.6
FetalThyroid4.35
Fetalbrain4.4
Fetalliver3.9
Fetallung3.65
GlobusPallidus3.4
Heart6
Hypothalamus4.85
Kidney3.7
Leukemia_chronicMyelogenousK-5624.05
Leukemia_promyelocytic-HL-603.9
Leukemialymphoblastic(MOLT-4)3.6
Liver6.15
Lung4.9
Lymphnode3.85
Lymphoma_burkitts(Daudi)5.8
Lymphoma_burkitts(Raji)6.55
MedullaOblongata4.05
OccipitalLobe4
OlfactoryBulb3.55
Ovary3.05
Pancreas3.65
PancreaticIslet4.8
ParietalLobe4.85
Pituitary5.2
Placenta4.55
Pons4.3
PrefrontalCortex5.5
Prostate5.2
Salivarygland3.65
SkeletalMuscle5.55
Skin3.75
SmoothMuscle5
Spinalcord5
SubthalamicNucleus4.15
SuperiorCervicalGanglion5.65
TemporalLobe4.15
Testis3.8
TestisGermCell3.7
TestisIntersitial3.8
TestisLeydigCell4.5
TestisSeminiferousTubule3.9
Thalamus4.55
Thymus3.45
Thyroid5.6
Tongue4.6
Tonsil4.35
Trachea3.75
TrigeminalGanglion5.1
Uterus3.65
UterusCorpus4.8
WholeBlood7.4
Wholebrain3.7
colon4.5
pineal_day5.56
pineal_night5.44
retina5.425
small_intestine4.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P94054
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.71 ± 0.34
Basal Forebrain6.55 ± 0.26
Basal Part of Pons6.63 ± 0.21
Cerebellar Cortex6.56 ± 0.32
Cerebellar Nuclei6.38 ± 0.5
Claustrum6.71 ± 0.45
Epithalamus6.73 ± 0.35
Frontal Lobe6.75 ± 0.33
Globus Pallidus6.83 ± 0.27
Hypothalamus6.48 ± 0.47
Insula6.76 ± 0.24
Limbic Lobe6.62 ± 0.39
Mesencephalon6.61 ± 0.43
Myelencephalon6.56 ± 0.38
Occipital Lobe6.31 ± 0.33
Parietal Lobe6.64 ± 0.34
Pontine Tegmentum6.58 ± 0.31
Striatum6.38 ± 0.26
Subthalamus6.62 ± 0.33
Temporal Lobe6.72 ± 0.29
Thalamus6.33 ± 0.31
White Matter7.29 ± 0.15
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
STK4_HUMAN_1 7 1 7 METVQLR PRIDE
STK4_HUMAN_119 16 119 134 TLTEDEIATILQSTLK PRIDE
STK4_HUMAN_25 11 25 35 QPEEVFDVLEK PRIDE
STK4_HUMAN_35 11 35 45 LGEGSYGSVYK PRIDE
STK4_HUMAN_448 16 448 463 LLALDPMMEQEIEEIR PRIDE
STK4_HUMAN_464 7 464 470 QKYQSKR PRIDE
STK4_HUMAN_471 12 471 482 QPILDAIEAKKR PRIDE
STK4_HUMAN_51 22 51 72 ETGQIVAIKQVPVESDLQEIIK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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