AutismKB 2.0

Annotation Detail for STX1A


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Basic Information Top
Gene Symbol:STX1A ( HPC-1,P35-1,STX1,SYN1A )
Gene Full Name: syntaxin 1A (brain)
Band: 7q11.23
Quick LinksEntrez ID:6804; OMIM: 186590; Uniprot ID:STX1A_HUMAN; ENSEMBL ID: ENSG00000106089; HGNC ID: 11433
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus52 / 56401292
neonate0 / 310970 
infant4 / 23620169
juvenile4 / 5555671
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor8 / 11936967
germ cell tumor19 / 26384572
glioma2 / 10688318
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor11 / 103127106
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal221 / 336030765
ovarian tumor7 / 7668291
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma4 / 4635686
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites5 / 40015124
bladder1 / 2975733
blood0 / 1234780 
bone7 / 7165597
bone marrow0 / 488010 
brain185 / 1100989168
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye13 / 21105461
heart0 / 896260 
intestine2 / 2344728
kidney5 / 21177723
larynx0 / 241450 
liver1 / 2077434
lung15 / 33697444
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth1 / 6705214
muscle1 / 1077159
nerve2 / 15768126
ovary8 / 10205178
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta0 / 2808250 
prostate2 / 18934510
salivary gland2 / 2015599
skin0 / 2105740 
spleen0 / 539520 
stomach4 / 9661941
testis6 / 33044218
thymus2 / 8113124
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204729_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.85
Adipocyte4.05
AdrenalCortex4.1
Adrenalgland3.4
Amygdala147.1
Appendix4.1
AtrioventricularNode3.1
BDCA4+_DentriticCells4.4
Bonemarrow4
BronchialEpithelialCells4
CD105+_Endothelial3.9
CD14+_Monocytes4.2
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid5
CD34+5.05
CD4+_Tcells4.4
CD56+_NKCells4.8
CD71+_EarlyErythroid3.65
CD8+_Tcells3.9
CardiacMyocytes5.15
Caudatenucleus3.7
Cerebellum17.55
CerebellumPeduncles10.7
CiliaryGanglion2.85
CingulateCortex64.5
Colorectaladenocarcinoma5.05
DorsalRootGanglion3.05
FetalThyroid3.9
Fetalbrain131.9
Fetalliver3.5
Fetallung3.4
GlobusPallidus98.15
Heart5
Hypothalamus7.85
Kidney3.25
Leukemia_chronicMyelogenousK-5623.7
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)3.25
Liver5.3
Lung4.45
Lymphnode3.5
Lymphoma_burkitts(Daudi)5.15
Lymphoma_burkitts(Raji)5.7
MedullaOblongata36.4
OccipitalLobe82.55
OlfactoryBulb3.2
Ovary2.6
Pancreas3.3
PancreaticIslet24.8
ParietalLobe45.25
Pituitary7.85
Placenta4.25
Pons9.9
PrefrontalCortex77
Prostate4.8
Salivarygland3.15
SkeletalMuscle4.85
Skin3
SmoothMuscle4.7
Spinalcord4.3
SubthalamicNucleus70.35
SuperiorCervicalGanglion4.45
TemporalLobe92.9
Testis3.5
TestisGermCell3.45
TestisIntersitial3.35
TestisLeydigCell3.95
TestisSeminiferousTubule3.5
Thalamus4.25
Thymus3.2
Thyroid5.15
Tongue3.95
Tonsil3.9
Trachea3.4
TrigeminalGanglion4
Uterus3.35
UterusCorpus3.65
WholeBlood4.45
Wholebrain306.1
colon4.05
pineal_day22.02
pineal_night17.24
retina4.9
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P226541
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.54 ± 0.91
Basal Forebrain7.48 ± 0.47
Basal Part of Pons8.63 ± 0.72
Cerebellar Cortex8.02 ± 0.46
Cerebellar Nuclei6.08 ± 0.76
Claustrum9.24 ± 0.44
Epithalamus6.29 ± 1.01
Frontal Lobe8.16 ± 0.83
Globus Pallidus5.37 ± 1.24
Hypothalamus7.42 ± 0.75
Insula8.43 ± 0.56
Limbic Lobe9.02 ± 0.77
Mesencephalon7.67 ± 0.99
Myelencephalon8.06 ± 0.89
Occipital Lobe8.44 ± 0.86
Parietal Lobe8.42 ± 1
Pontine Tegmentum7.76 ± 0.94
Striatum6.45 ± 1.28
Subthalamus6.96 ± 0.25
Temporal Lobe8.59 ± 0.53
Thalamus7.85 ± 0.55
White Matter6.3 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Stx1aCBCerebellum14.44
9.65
Stx1aCTXCerebral cortex100
100
Stx1aHIPHippocampal region65.01
64.43
Stx1aHPFHippocampal formation96.84
92.86
Stx1aHYHypothalamus74.67
38.16
Stx1aLSXLateral septal complex23.38
12.25
Stx1aMBMidbrain52.79
29.75
Stx1aMYMedulla36.33
23.29
Stx1aOLFOlfactory bulb100
100
Stx1aPPons45.24
27.71
Stx1aPALPallidum39.5
23.96
Stx1aRHPRetrohippocampal region100
100
Stx1asAMYStriatum-like amygdalar nuclei71.77
53.64
Stx1aSTRStriatum31.81
20.13
Stx1aSTRdStriatum dorsal region18.69
13.58
Stx1aSTRvStriatum ventral region63.23
26.78
Stx1aTHThalamus52.86
33.01
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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