AutismKB 2.0

Annotation Detail for MED22


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Basic Information Top
Gene Symbol:MED22 ( MED24,MGC48682,SURF5 )
Gene Full Name: mediator complex subunit 22
Band: 9q34.2
Quick LinksEntrez ID:6837; OMIM: 185641; Uniprot ID:MED22_HUMAN; ENSEMBL ID: ENSG00000148297; HGNC ID: 11477
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst4 / 6231964
fetus34 / 56401260
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor3 / 3436687
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor36 / 263845136
glioma6 / 10688356
head and neck tumor4 / 13630229
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor7 / 10312767
lymphoma7 / 7175597
non-neoplasia3 / 9725030
normal167 / 336030749
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer4 / 10268038
retinoblastoma3 / 4635664
skin tumor15 / 124949120
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites6 / 40015149
bladder0 / 297570 
blood4 / 12347832
bone0 / 716550 
bone marrow2 / 4880140
brain83 / 110098975
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye18 / 21105485
heart6 / 8962666
intestine7 / 23447229
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung10 / 33697429
lymph2 / 4427045
lymph node11 / 91610120
mammary gland14 / 15327191
mouth2 / 6705229
muscle9 / 10771583
nerve0 / 157680 
ovary3 / 10205129
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate8 / 18934542
salivary gland2 / 2015599
skin19 / 21057490
spleen4 / 5395274
stomach1 / 9661910
testis32 / 33044296
thymus12 / 81131147
thyroid0 / 474730 
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord0 / 136800 
uterus19 / 23287881
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206593_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.5
Adipocyte5.25
AdrenalCortex6.1
Adrenalgland4.5
Amygdala5.8
Appendix5.3
AtrioventricularNode4.05
BDCA4+_DentriticCells14.3
Bonemarrow4.95
BronchialEpithelialCells5.35
CD105+_Endothelial5
CD14+_Monocytes7.15
CD19+_BCells(neg._sel.)22.8
CD33+_Myeloid7
CD34+7.1
CD4+_Tcells6.5
CD56+_NKCells8.45
CD71+_EarlyErythroid4.7
CD8+_Tcells6.45
CardiacMyocytes7.35
Caudatenucleus5.3
Cerebellum7.35
CerebellumPeduncles7.1
CiliaryGanglion3.75
CingulateCortex5.55
Colorectaladenocarcinoma12
DorsalRootGanglion4.1
FetalThyroid5.35
Fetalbrain5.45
Fetalliver4.65
Fetallung4.45
GlobusPallidus5.15
Heart12.45
Hypothalamus6.4
Kidney4.3
Leukemia_chronicMyelogenousK-5624.45
Leukemia_promyelocytic-HL-605
Leukemialymphoblastic(MOLT-4)5.65
Liver7.05
Lung6.15
Lymphnode4.65
Lymphoma_burkitts(Daudi)7.9
Lymphoma_burkitts(Raji)17.3
MedullaOblongata5
OccipitalLobe4.85
OlfactoryBulb4.3
Ovary3.6
Pancreas3.6
PancreaticIslet5.3
ParietalLobe5.65
Pituitary6.6
Placenta5.9
Pons5.15
PrefrontalCortex9.8
Prostate10.45
Salivarygland4.3
SkeletalMuscle6.05
Skin3.95
SmoothMuscle6.2
Spinalcord7.95
SubthalamicNucleus5.85
SuperiorCervicalGanglion5.75
TemporalLobe4.9
Testis4.65
TestisGermCell4.3
TestisIntersitial3.75
TestisLeydigCell4.85
TestisSeminiferousTubule4.6
Thalamus5.8
Thymus4.1
Thyroid13.8
Tongue5
Tonsil5.3
Trachea4.45
TrigeminalGanglion5.15
Uterus4.1
UterusCorpus4.8
WholeBlood6.05
Wholebrain8.3
colon5.4
pineal_day7.64
pineal_night6.68
retina7.225
small_intestine5.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P55719
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.34 ± 0.93
Basal Forebrain2.97 ± 0.33
Basal Part of Pons2.97 ± 0.71
Cerebellar Cortex3.46 ± 0.42
Cerebellar Nuclei3.31 ± 0.64
Claustrum3.32 ± 0.58
Epithalamus2.9 ± 0.6
Frontal Lobe3.18 ± 0.64
Globus Pallidus2.7 ± 0.65
Hypothalamus2.92 ± 0.53
Insula3.04 ± 0.67
Limbic Lobe3 ± 0.53
Mesencephalon3.18 ± 0.64
Myelencephalon3.13 ± 0.57
Occipital Lobe2.85 ± 0.64
Parietal Lobe3.18 ± 0.57
Pontine Tegmentum3.06 ± 0.6
Striatum2.78 ± 0.7
Subthalamus3.17 ± 0.71
Temporal Lobe3.11 ± 0.62
Thalamus3.06 ± 0.53
White Matter3.4 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Surf5CBCerebellum1.05
1.29
Surf5CTXCerebral cortex0.25
0.38
Surf5HIPHippocampal region0.18
0.27
Surf5HPFHippocampal formation0.18
0.22
Surf5HYHypothalamus0.01
0.02
Surf5LSXLateral septal complex0
0
Surf5MBMidbrain0.15
0.2
Surf5MYMedulla0.11
0.16
Surf5OLFOlfactory bulb0.36
1.14
Surf5PPons0.12
0.18
Surf5PALPallidum0
0
Surf5RHPRetrohippocampal region0.19
0.14
Surf5sAMYStriatum-like amygdalar nuclei0.1
0.23
Surf5STRStriatum0.02
0.06
Surf5STRdStriatum dorsal region0.02
0.06
Surf5STRvStriatum ventral region0
0
Surf5THThalamus0.08
0.09
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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