AutismKB 2.0

Annotation Detail for SVIL


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Basic Information Top
Gene Symbol:SVIL ( DKFZp686A17191 )
Gene Full Name: supervillin
Band: 10p11.23
Quick LinksEntrez ID:6840; OMIM: 604126; Uniprot ID:SVIL_HUMAN; ENSEMBL ID: ENSG00000197321; HGNC ID: 11480
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst2 / 6231932
fetus34 / 56401260
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult174 / 193912189
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor14 / 94178148
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor6 / 26384522
glioma6 / 10688356
head and neck tumor16 / 136302117
kidney tumor4 / 6895958
leukemia12 / 95842125
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal208 / 336030761
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood11 / 12347889
bone0 / 716550 
bone marrow0 / 488010 
brain28 / 110098925
cervix1 / 4817120
connective tissue3 / 14925520
ear2 / 16212123
embryonic tissue16 / 21572274
esophagus1 / 2020949
eye7 / 21105433
heart17 / 89626189
intestine26 / 234472110
kidney16 / 21177775
larynx13 / 24145538
liver7 / 20774333
lung12 / 33697435
lymph0 / 442700 
lymph node0 / 916100 
mammary gland25 / 153271163
mouth0 / 670520 
muscle31 / 107715287
nerve2 / 15768126
ovary2 / 10205119
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta4 / 28082514
prostate16 / 18934584
salivary gland0 / 201550 
skin8 / 21057437
spleen1 / 5395218
stomach7 / 9661972
testis10 / 33044230
thymus2 / 8113124
thyroid5 / 47473105
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus25 / 232878107
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202566_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.1
Adipocyte9.8
AdrenalCortex8.05
Adrenalgland6.45
Amygdala7.15
Appendix12.75
AtrioventricularNode6.75
BDCA4+_DentriticCells6.7
Bonemarrow7.9
BronchialEpithelialCells6.8
CD105+_Endothelial6.8
CD14+_Monocytes7.6
CD19+_BCells(neg._sel.)7
CD33+_Myeloid9
CD34+8.15
CD4+_Tcells8.15
CD56+_NKCells7.8
CD71+_EarlyErythroid6.65
CD8+_Tcells6.8
CardiacMyocytes11.5
Caudatenucleus6.35
Cerebellum5.95
CerebellumPeduncles8.8
CiliaryGanglion6.7
CingulateCortex7.4
Colorectaladenocarcinoma7.45
DorsalRootGanglion6.4
FetalThyroid8.7
Fetalbrain6.95
Fetalliver6.4
Fetallung13.4
GlobusPallidus5.35
Heart15.15
Hypothalamus7.35
Kidney6.15
Leukemia_chronicMyelogenousK-5626.55
Leukemia_promyelocytic-HL-606.25
Leukemialymphoblastic(MOLT-4)6.1
Liver10.7
Lung8
Lymphnode8.15
Lymphoma_burkitts(Daudi)9.2
Lymphoma_burkitts(Raji)10.55
MedullaOblongata6.35
OccipitalLobe6.3
OlfactoryBulb6.2
Ovary5.4
Pancreas5.75
PancreaticIslet7.7
ParietalLobe7.9
Pituitary8.5
Placenta7.2
Pons7.1
PrefrontalCortex8.45
Prostate32.6
Salivarygland6.15
SkeletalMuscle25.05
Skin7.5
SmoothMuscle9.1
Spinalcord7.8
SubthalamicNucleus6.75
SuperiorCervicalGanglion11.35
TemporalLobe6.65
Testis8.6
TestisGermCell19.8
TestisIntersitial6.5
TestisLeydigCell11.25
TestisSeminiferousTubule6.4
Thalamus7.25
Thymus8.25
Thyroid14.65
Tongue9.95
Tonsil7.3
Trachea9.4
TrigeminalGanglion11.45
Uterus76.85
UterusCorpus17.55
WholeBlood17.3
Wholebrain5.7
colon42.9
pineal_day8.62
pineal_night9.1
retina23.375
small_intestine9.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P35349
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.94 ± 0.98
Basal Forebrain3.52 ± 0.71
Basal Part of Pons2.51 ± 0.49
Cerebellar Cortex3.18 ± 0.59
Cerebellar Nuclei3.13 ± 0.57
Claustrum3.3 ± 0.73
Epithalamus2.96 ± 0.69
Frontal Lobe2.77 ± 0.69
Globus Pallidus2.97 ± 0.91
Hypothalamus2.74 ± 0.62
Insula2.88 ± 0.67
Limbic Lobe2.71 ± 0.65
Mesencephalon3.04 ± 0.72
Myelencephalon2.94 ± 0.7
Occipital Lobe3.05 ± 0.73
Parietal Lobe2.72 ± 0.65
Pontine Tegmentum3.03 ± 0.65
Striatum3.14 ± 0.66
Subthalamus2.81 ± 0.8
Temporal Lobe2.93 ± 0.72
Thalamus3.03 ± 0.64
White Matter2.35 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SvilCBCerebellum26.55
60.05
SvilCTXCerebral cortex31.47
23.34
SvilHIPHippocampal region22.69
22.47
SvilHPFHippocampal formation22.76
20.21
SvilHYHypothalamus8.79
7.03
SvilLSXLateral septal complex9.97
6.96
SvilMBMidbrain10.46
9.73
SvilMYMedulla16.84
18.43
SvilOLFOlfactory bulb37.15
29.55
SvilPPons13.02
13.69
SvilPALPallidum11.19
9.46
SvilRHPRetrohippocampal region23.12
17.16
SvilsAMYStriatum-like amygdalar nuclei12.84
9.9
SvilSTRStriatum19.81
15.04
SvilSTRdStriatum dorsal region20.77
16.36
SvilSTRvStriatum ventral region23.37
15.71
SvilTHThalamus12.61
10.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009713 19 671 689 CTSHSETPTVDDEEKVDER Peptide Atlas
SVIL_HUMAN_1276 21 1276 1296 LNNKVGGMHETVLTVTGKSVK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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