AutismKB 2.0

Annotation Detail for VAMP2


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Basic Information Top
Gene Symbol:VAMP2 ( FLJ11460,SYB2,VAMP-2 )
Gene Full Name: vesicle-associated membrane protein 2 (synaptobrevin 2)
Band: 17p13.1
Quick LinksEntrez ID:6844; OMIM: 185881; Uniprot ID:VAMP2_HUMAN; ENSEMBL ID: ENSG00000220205; HGNC ID: 12643
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus32 / 56401256
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult181 / 193912193
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor13 / 26384549
glioma9 / 10688384
head and neck tumor11 / 13630280
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma3 / 7175541
non-neoplasia4 / 9725041
normal297 / 336030788
ovarian tumor3 / 7668239
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder1 / 2975733
blood6 / 12347848
bone9 / 71655125
bone marrow1 / 4880120
brain137 / 1100989124
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye39 / 211054184
heart5 / 8962655
intestine8 / 23447234
kidney19 / 21177789
larynx1 / 2414541
liver0 / 2077430 
lung26 / 33697477
lymph2 / 4427045
lymph node4 / 9161043
mammary gland6 / 15327139
mouth0 / 670520 
muscle3 / 10771527
nerve4 / 15768253
ovary4 / 10205139
pancreas27 / 214812125
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta16 / 28082556
prostate9 / 18934547
salivary gland1 / 2015549
skin5 / 21057423
spleen0 / 539520 
stomach6 / 9661962
testis9 / 33044227
thymus0 / 811310 
thyroid9 / 47473189
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214792_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts40.45
Adipocyte36.8
AdrenalCortex42.85
Adrenalgland64.15
Amygdala593.75
Appendix42
AtrioventricularNode30.55
BDCA4+_DentriticCells19.3
Bonemarrow38.3
BronchialEpithelialCells29.2
CD105+_Endothelial17.75
CD14+_Monocytes24.5
CD19+_BCells(neg._sel.)40.8
CD33+_Myeloid24.85
CD34+14.25
CD4+_Tcells36.8
CD56+_NKCells46.3
CD71+_EarlyErythroid30.4
CD8+_Tcells38.15
CardiacMyocytes46.75
Caudatenucleus78.15
Cerebellum97.75
CerebellumPeduncles112.75
CiliaryGanglion25.15
CingulateCortex122.2
Colorectaladenocarcinoma64.15
DorsalRootGanglion30.2
FetalThyroid35.6
Fetalbrain46.35
Fetalliver28.9
Fetallung26.25
GlobusPallidus50.45
Heart120.7
Hypothalamus113.95
Kidney40.6
Leukemia_chronicMyelogenousK-56228.5
Leukemia_promyelocytic-HL-6028.15
Leukemialymphoblastic(MOLT-4)27.75
Liver53.6
Lung41.35
Lymphnode32.65
Lymphoma_burkitts(Daudi)41.75
Lymphoma_burkitts(Raji)73.7
MedullaOblongata164.15
OccipitalLobe112.1
OlfactoryBulb37.25
Ovary49
Pancreas25.6
PancreaticIslet35.65
ParietalLobe71.3
Pituitary56.1
Placenta69.65
Pons138.85
PrefrontalCortex348.55
Prostate45.6
Salivarygland30.15
SkeletalMuscle49.8
Skin25.6
SmoothMuscle30
Spinalcord53.2
SubthalamicNucleus49.9
SuperiorCervicalGanglion43.25
TemporalLobe107.2
Testis39.25
TestisGermCell32.25
TestisIntersitial31.55
TestisLeydigCell36.35
TestisSeminiferousTubule35.2
Thalamus186.2
Thymus24.3
Thyroid85.35
Tongue42.6
Tonsil30.5
Trachea33.4
TrigeminalGanglion40.05
Uterus30.15
UterusCorpus36.6
WholeBlood48.85
Wholebrain167.55
colon32.35
pineal_day768.6
pineal_night632.82
retina338.85
small_intestine30.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P313576
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.04 ± 0.34
Basal Forebrain8.65 ± 0.19
Basal Part of Pons8.78 ± 0.34
Cerebellar Cortex8.43 ± 0.17
Cerebellar Nuclei8.73 ± 0.48
Claustrum9.28 ± 0.49
Epithalamus7.91 ± 0.44
Frontal Lobe8.86 ± 0.44
Globus Pallidus8.45 ± 0.41
Hypothalamus8.5 ± 0.29
Insula8.74 ± 0.28
Limbic Lobe8.95 ± 0.4
Mesencephalon8.75 ± 0.4
Myelencephalon8.85 ± 0.41
Occipital Lobe8.6 ± 0.28
Parietal Lobe8.83 ± 0.4
Pontine Tegmentum8.73 ± 0.41
Striatum8.65 ± 0.52
Subthalamus8.82 ± 0.12
Temporal Lobe8.88 ± 0.28
Thalamus9.01 ± 0.28
White Matter8.29 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Vamp2CBCerebellum3.64
3.73
Vamp2CTXCerebral cortex52.86
47.28
Vamp2HIPHippocampal region53.74
59.76
Vamp2HPFHippocampal formation58.13
57.69
Vamp2HYHypothalamus16.5
13.33
Vamp2LSXLateral septal complex13.15
9.19
Vamp2MBMidbrain13.67
13.16
Vamp2MYMedulla5.9
3.74
Vamp2OLFOlfactory bulb61.91
59.11
Vamp2PPons20.52
20.65
Vamp2PALPallidum20.85
22.87
Vamp2RHPRetrohippocampal region55.23
54.37
Vamp2sAMYStriatum-like amygdalar nuclei28.12
23.25
Vamp2STRStriatum12.95
11.07
Vamp2STRdStriatum dorsal region8.37
8.07
Vamp2STRvStriatum ventral region19.22
13.28
Vamp2THThalamus23.25
20.83
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00005321 24 60 83 LSELDDRADALQAGASQFETSAAK Peptide Atlas
VAMP2_HUMAN_30 17 30 46 RLQQTQAQVDEVVDIMR PRIDE
VAMP2_HUMAN_31 16 31 46 LQQTQAQVDEVVDIMR PRIDE
VAMP2_HUMAN_47 12 47 58 VNVDKVLERDQK PRIDE
VAMP2_HUMAN_47 9 47 55 VNVDKVLER PRIDE
VAMP2_HUMAN_59 24 59 82 LSELDDRADALQAGASQFETSAAK PRIDE
VAMP2_HUMAN_66 17 66 82 ADALQAGASQFETSAAK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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