AutismKB 2.0

Annotation Detail for SYN1


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Basic Information Top
Gene Symbol:SYN1 ( SYN1a,SYN1b,SYNI )
Gene Full Name: synapsin I
Band: Xp11.3-p11.23
Quick LinksEntrez ID:6853; OMIM: 313440; Uniprot ID:SYN1_HUMAN; ENSEMBL ID: ENSG00000008056; HGNC ID: 11494
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult63 / 193912132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal76 / 336030722
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain65 / 110098959
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221914_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.8
Adipocyte4
AdrenalCortex4.35
Adrenalgland3.45
Amygdala444.95
Appendix5.15
AtrioventricularNode3.1
BDCA4+_DentriticCells4.35
Bonemarrow3.9
BronchialEpithelialCells3.85
CD105+_Endothelial4
CD14+_Monocytes4.15
CD19+_BCells(neg._sel.)4.15
CD33+_Myeloid5.05
CD34+5
CD4+_Tcells4.25
CD56+_NKCells4.65
CD71+_EarlyErythroid3.7
CD8+_Tcells3.8
CardiacMyocytes5.05
Caudatenucleus32.7
Cerebellum85.25
CerebellumPeduncles51.15
CiliaryGanglion2.8
CingulateCortex172.35
Colorectaladenocarcinoma3.95
DorsalRootGanglion3.15
FetalThyroid3.85
Fetalbrain10.15
Fetalliver3.5
Fetallung3.3
GlobusPallidus105
Heart5.15
Hypothalamus22.5
Kidney3.25
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)3.15
Liver5.35
Lung4.4
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.1
Lymphoma_burkitts(Raji)5.55
MedullaOblongata94.15
OccipitalLobe116.9
OlfactoryBulb3.2
Ovary2.7
Pancreas3.2
PancreaticIslet4.3
ParietalLobe73.15
Pituitary13.15
Placenta4.15
Pons72.45
PrefrontalCortex436.9
Prostate4.6
Salivarygland3.25
SkeletalMuscle4.75
Skin3.05
SmoothMuscle4.45
Spinalcord15.35
SubthalamicNucleus100.8
SuperiorCervicalGanglion4.6
TemporalLobe84.75
Testis3.5
TestisGermCell3.35
TestisIntersitial3.4
TestisLeydigCell4
TestisSeminiferousTubule3.4
Thalamus64.2
Thymus3.1
Thyroid4.95
Tongue3.9
Tonsil3.9
Trachea3.45
TrigeminalGanglion4.15
Uterus3.3
UterusCorpus4.05
WholeBlood4.3
Wholebrain259.7
colon4.05
pineal_day47.9
pineal_night41.4
retina5.975
small_intestine3.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_619_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.28 ± 0.42
Basal Forebrain8.33 ± 0.29
Basal Part of Pons9.13 ± 0.39
Cerebellar Cortex8.54 ± 0.31
Cerebellar Nuclei7.96 ± 0.59
Claustrum9.47 ± 0.43
Epithalamus7.21 ± 0.99
Frontal Lobe8.55 ± 0.62
Globus Pallidus7.13 ± 0.5
Hypothalamus8.43 ± 0.59
Insula8.71 ± 0.4
Limbic Lobe9.26 ± 0.5
Mesencephalon8.48 ± 0.8
Myelencephalon8.57 ± 0.65
Occipital Lobe9.13 ± 0.57
Parietal Lobe8.81 ± 0.6
Pontine Tegmentum8.48 ± 0.52
Striatum7.92 ± 0.68
Subthalamus8.48 ± 0.26
Temporal Lobe8.78 ± 0.42
Thalamus8.36 ± 0.39
White Matter6.17 ± 0.65
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Syn1CBCerebellum82.72
100
Syn1CTXCerebral cortex100
100
Syn1HIPHippocampal region100
100
Syn1HPFHippocampal formation100
100
Syn1HYHypothalamus100
100
Syn1LSXLateral septal complex100
100
Syn1MBMidbrain100
100
Syn1MYMedulla100
100
Syn1OLFOlfactory bulb100
100
Syn1PPons100
100
Syn1PALPallidum100
100
Syn1RHPRetrohippocampal region100
100
Syn1sAMYStriatum-like amygdalar nuclei100
100
Syn1STRStriatum100
100
Syn1STRdStriatum dorsal region100
100
Syn1STRvStriatum ventral region100
100
Syn1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00436572 25 532 556 QSRPVAGGPGAPPAARPPASPSPQR Peptide Atlas
SYN1_HUMAN_257 13 257 269 EMLSSTTYPVVVK PRIDE
SYN1_HUMAN_319 6 319 324 IGQNYK PRIDE
SYN1_HUMAN_337 16 337 352 TNTGSAMLEQIAMSDR PRIDE
SYN1_HUMAN_431 16 431 446 GSHGQTPSPGALPLGR PRIDE
SYN1_HUMAN_532 25 532 556 QSRPVAGGPGAPPAARPPASPSPQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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