AutismKB 2.0

Annotation Detail for SYPL1


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Basic Information Top
Gene Symbol:SYPL1 ( H-SP1,SYPL )
Gene Full Name: synaptophysin-like 1
Band: 7q22.2
Quick LinksEntrez ID:6856; OMIM: NA; Uniprot ID:SYPL1_HUMAN; ENSEMBL ID: ENSG00000008282; HGNC ID: 11507
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst5 / 6231980
fetus28 / 56401249
neonate8 / 31097257
infant1 / 2362042
juvenile21 / 55556377
adult227 / 1939121117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma11 / 17475629
breast (mammary gland) tumor14 / 94178148
cervical tumor2 / 3436658
chondrosarcoma7 / 8282384
colorectal tumor11 / 11424696
esophageal tumor31 / 172901792
gastrointestinal tumor17 / 119369142
germ cell tumor43 / 263845162
glioma12 / 106883112
head and neck tumor21 / 136302154
kidney tumor34 / 68959493
leukemia20 / 95842208
liver tumor19 / 96359197
lung tumor6 / 10312758
lymphoma7 / 7175597
non-neoplasia23 / 97250236
normal479 / 3360307142
ovarian tumor7 / 7668291
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer17 / 102680165
retinoblastoma0 / 463560 
skin tumor10 / 12494980
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland8 / 33197240
ascites4 / 4001599
bladder25 / 29757840
blood15 / 123478121
bone6 / 7165583
bone marrow16 / 48801327
brain172 / 1100989156
cervix6 / 48171124
connective tissue40 / 149255267
ear0 / 162120 
embryonic tissue26 / 215722120
esophagus32 / 202091583
eye12 / 21105456
heart18 / 89626200
intestine36 / 234472153
kidney75 / 211777354
larynx2 / 2414582
liver30 / 207743144
lung34 / 336974100
lymph3 / 4427067
lymph node7 / 9161076
mammary gland15 / 15327197
mouth12 / 67052178
muscle14 / 107715129
nerve2 / 15768126
ovary7 / 10205168
pancreas22 / 214812102
parathyroid7 / 20539340
pharynx5 / 41328120
pituitary gland2 / 16585120
placenta35 / 280825124
prostate32 / 189345169
salivary gland2 / 2015599
skin22 / 210574104
spleen15 / 53952278
stomach13 / 96619134
testis117 / 330442354
thymus14 / 81131172
thyroid6 / 47473126
tonsil0 / 169990 
trachea13 / 52413248
umbilical cord1 / 1368073
uterus38 / 232878163
vascular19 / 51780366
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201260_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts198
Adipocyte116.1
AdrenalCortex69
Adrenalgland98.8
Amygdala73.9
Appendix95.3
AtrioventricularNode47.35
BDCA4+_DentriticCells104.15
Bonemarrow69.15
BronchialEpithelialCells813.4
CD105+_Endothelial87.6
CD14+_Monocytes111.55
CD19+_BCells(neg._sel.)511.25
CD33+_Myeloid125
CD34+472.75
CD4+_Tcells59
CD56+_NKCells59.85
CD71+_EarlyErythroid30.05
CD8+_Tcells67.35
CardiacMyocytes100.65
Caudatenucleus80.9
Cerebellum41.5
CerebellumPeduncles54.55
CiliaryGanglion47.65
CingulateCortex52.35
Colorectaladenocarcinoma532.2
DorsalRootGanglion45.5
FetalThyroid106
Fetalbrain47.35
Fetalliver62.05
Fetallung110.75
GlobusPallidus27.85
Heart68.45
Hypothalamus251.1
Kidney77.25
Leukemia_chronicMyelogenousK-562100.4
Leukemia_promyelocytic-HL-60173.95
Leukemialymphoblastic(MOLT-4)206.25
Liver73.3
Lung103.6
Lymphnode199.8
Lymphoma_burkitts(Daudi)181.85
Lymphoma_burkitts(Raji)208.7
MedullaOblongata66.25
OccipitalLobe94.75
OlfactoryBulb146.2
Ovary58.2
Pancreas149.5
PancreaticIslet123.2
ParietalLobe66.65
Pituitary69.05
Placenta305.3
Pons45.55
PrefrontalCortex88.9
Prostate416.3
Salivarygland261.3
SkeletalMuscle52.15
Skin87.65
SmoothMuscle144.65
Spinalcord554.25
SubthalamicNucleus47
SuperiorCervicalGanglion72.05
TemporalLobe47.25
Testis252.4
TestisGermCell172.1
TestisIntersitial102.55
TestisLeydigCell171.55
TestisSeminiferousTubule114.15
Thalamus102.3
Thymus84.75
Thyroid1217
Tongue153.85
Tonsil163.7
Trachea304.9
TrigeminalGanglion71
Uterus675.65
UterusCorpus86.7
WholeBlood137.85
Wholebrain110.35
colon637.25
pineal_day49.42
pineal_night50.76
retina302.175
small_intestine829.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P141005
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.34 ± 0.85
Basal Forebrain4.87 ± 0.51
Basal Part of Pons4.61 ± 0.61
Cerebellar Cortex4.46 ± 0.45
Cerebellar Nuclei5.9 ± 0.97
Claustrum4.35 ± 0.7
Epithalamus5.21 ± 0.75
Frontal Lobe4.81 ± 0.76
Globus Pallidus6.51 ± 0.45
Hypothalamus4.77 ± 0.49
Insula4.2 ± 0.48
Limbic Lobe4.33 ± 0.67
Mesencephalon4.99 ± 0.75
Myelencephalon4.92 ± 0.66
Occipital Lobe4.89 ± 0.64
Parietal Lobe4.66 ± 0.8
Pontine Tegmentum5.01 ± 0.52
Striatum5.24 ± 0.64
Subthalamus5.12 ± 0.42
Temporal Lobe4.54 ± 0.6
Thalamus5.16 ± 0.5
White Matter7.36 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SyplCBCerebellum27.1
26.15
SyplCTXCerebral cortex33.98
21.74
SyplHIPHippocampal region23.49
21.43
SyplHPFHippocampal formation24.73
20.27
SyplHYHypothalamus20.72
13.6
SyplLSXLateral septal complex15.23
9.46
SyplMBMidbrain25.74
18.27
SyplMYMedulla52.27
42.38
SyplOLFOlfactory bulb34.17
23.1
SyplPPons53.35
37.77
SyplPALPallidum25.89
17.95
SyplRHPRetrohippocampal region28.7
19.91
SyplsAMYStriatum-like amygdalar nuclei27.17
17.94
SyplSTRStriatum27.7
17.61
SyplSTRdStriatum dorsal region32.24
20.88
SyplSTRvStriatum ventral region18.31
10.5
SyplTHThalamus27.14
17.9
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002251 25 235 259 ETSLHSPSNTSAPHSQGGIPPPTGI Peptide Atlas
SYPL1_HUMAN_72 11 72 82 TVTATFGYPFR PRIDE
SYPL1_HUMAN_73 11 73 83 TVTATFGYPFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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