AutismKB 2.0

Annotation Detail for MAP3K7


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Basic Information Top
Gene Symbol:MAP3K7 ( MEKK7,TAK1,TGF1a )
Gene Full Name: mitogen-activated protein kinase kinase kinase 7
Band: 6q15
Quick LinksEntrez ID:6885; OMIM: 602614; Uniprot ID:M3K7_HUMAN; ENSEMBL ID: ENSG00000135341; HGNC ID: 6859
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst4 / 6231964
fetus28 / 56401249
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult90 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor18 / 26384568
glioma4 / 10688337
head and neck tumor13 / 13630295
kidney tumor8 / 68959116
leukemia4 / 9584241
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia9 / 9725092
normal164 / 336030748
ovarian tumor6 / 7668278
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood4 / 12347832
bone3 / 7165541
bone marrow1 / 4880120
brain55 / 110098949
cervix1 / 4817120
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine6 / 23447225
kidney16 / 21177775
larynx0 / 241450 
liver3 / 20774314
lung6 / 33697417
lymph2 / 4427045
lymph node7 / 9161076
mammary gland7 / 15327145
mouth7 / 67052104
muscle6 / 10771555
nerve0 / 157680 
ovary6 / 10205158
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta16 / 28082556
prostate3 / 18934515
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach3 / 9661931
testis24 / 33044272
thymus7 / 8113186
thyroid7 / 47473147
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus13 / 23287855
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211537_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts50.2
Adipocyte9.5
AdrenalCortex7.5
Adrenalgland6.85
Amygdala13.75
Appendix7.4
AtrioventricularNode7.15
BDCA4+_DentriticCells17.1
Bonemarrow8.4
BronchialEpithelialCells15.25
CD105+_Endothelial9.15
CD14+_Monocytes11.05
CD19+_BCells(neg._sel.)13.9
CD33+_Myeloid24.6
CD34+14
CD4+_Tcells55.35
CD56+_NKCells22
CD71+_EarlyErythroid8.95
CD8+_Tcells51.25
CardiacMyocytes24.45
Caudatenucleus7.4
Cerebellum7.15
CerebellumPeduncles8.6
CiliaryGanglion5.4
CingulateCortex8
Colorectaladenocarcinoma10.2
DorsalRootGanglion6.6
FetalThyroid7.9
Fetalbrain10.7
Fetalliver10
Fetallung7.05
GlobusPallidus6.55
Heart10.9
Hypothalamus10.4
Kidney5.8
Leukemia_chronicMyelogenousK-5628.65
Leukemia_promyelocytic-HL-607.4
Leukemialymphoblastic(MOLT-4)7.45
Liver11.85
Lung8.25
Lymphnode8
Lymphoma_burkitts(Daudi)23.3
Lymphoma_burkitts(Raji)12.85
MedullaOblongata7.45
OccipitalLobe9.35
OlfactoryBulb7.95
Ovary5.65
Pancreas6.05
PancreaticIslet8.7
ParietalLobe9.45
Pituitary16.55
Placenta10.25
Pons7.5
PrefrontalCortex13.6
Prostate8.95
Salivarygland6.15
SkeletalMuscle14.05
Skin6.15
SmoothMuscle32.05
Spinalcord8.5
SubthalamicNucleus7
SuperiorCervicalGanglion9.8
TemporalLobe6.45
Testis5.75
TestisGermCell16.95
TestisIntersitial9.1
TestisLeydigCell7.75
TestisSeminiferousTubule15.3
Thalamus7.65
Thymus7.05
Thyroid11.6
Tongue7.2
Tonsil16.15
Trachea9.75
TrigeminalGanglion8.2
Uterus10.5
UterusCorpus10.8
WholeBlood12.25
Wholebrain7
colon13.45
pineal_day31.76
pineal_night23.36
retina10.3
small_intestine7.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16785_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.73 ± 0.17
Basal Forebrain7.54 ± 0.24
Basal Part of Pons7.94 ± 0.22
Cerebellar Cortex7.54 ± 0.31
Cerebellar Nuclei7.75 ± 0.37
Claustrum7.71 ± 0.32
Epithalamus7.66 ± 0.27
Frontal Lobe7.56 ± 0.29
Globus Pallidus7.61 ± 0.28
Hypothalamus7.49 ± 0.3
Insula7.36 ± 0.48
Limbic Lobe7.8 ± 0.31
Mesencephalon7.54 ± 0.33
Myelencephalon7.57 ± 0.29
Occipital Lobe7.94 ± 0.34
Parietal Lobe7.68 ± 0.27
Pontine Tegmentum7.55 ± 0.27
Striatum7.73 ± 0.25
Subthalamus7.53 ± 0.2
Temporal Lobe7.55 ± 0.28
Thalamus7.43 ± 0.25
White Matter8.08 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map3k7CBCerebellum22.02
17.41
Map3k7CTXCerebral cortex60.38
28.33
Map3k7HIPHippocampal region59.64
32.6
Map3k7HPFHippocampal formation60.29
31.57
Map3k7HYHypothalamus25.88
12.78
Map3k7LSXLateral septal complex23.59
10.33
Map3k7MBMidbrain25.46
14.46
Map3k7MYMedulla29.92
23.4
Map3k7OLFOlfactory bulb63.55
28.36
Map3k7PPons31.84
22.78
Map3k7PALPallidum14.73
9.33
Map3k7RHPRetrohippocampal region61.01
29.82
Map3k7sAMYStriatum-like amygdalar nuclei22.83
10.62
Map3k7STRStriatum14.58
6.43
Map3k7STRdStriatum dorsal region11.44
5.06
Map3k7STRvStriatum ventral region15.05
6.11
Map3k7THThalamus26.71
14.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00077550 18 439 456 SIQDLTVTGTEPGQVSSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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