AutismKB 2.0

Annotation Detail for TCF4


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Basic Information Top
Gene Symbol:TCF4 ( E2-2,ITF2,MGC149723,MGC149724,PTHS,SEF2,SEF2-1,SEF2-1A,SEF2-1B,bHLHb19 )
Gene Full Name: transcription factor 4
Band: 18q21.2
Quick LinksEntrez ID:6925; OMIM: 602272; Uniprot ID:ITF2_HUMAN; ENSEMBL ID: ENSG00000196628; HGNC ID: 11634
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst2 / 6231932
fetus202 / 564012358
neonate7 / 31097225
infant2 / 2362084
juvenile5 / 5555689
adult156 / 193912180
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor4 / 11424635
esophageal tumor3 / 17290173
gastrointestinal tumor6 / 11936950
germ cell tumor34 / 263845128
glioma10 / 10688393
head and neck tumor14 / 136302102
kidney tumor10 / 68959145
leukemia9 / 9584293
liver tumor3 / 9635931
lung tumor6 / 10312758
lymphoma6 / 7175583
non-neoplasia15 / 97250154
normal1113 / 3360307331
ovarian tumor6 / 7668278
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland4 / 33197120
ascites3 / 4001574
bladder1 / 2975733
blood11 / 12347889
bone5 / 7165569
bone marrow12 / 48801245
brain205 / 1100989186
cervix0 / 481710 
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue29 / 215722134
esophagus3 / 20209148
eye29 / 211054137
heart22 / 89626245
intestine14 / 23447259
kidney26 / 211777122
larynx0 / 241450 
liver4 / 20774319
lung50 / 336974148
lymph2 / 4427045
lymph node25 / 91610272
mammary gland5 / 15327132
mouth19 / 67052283
muscle6 / 10771555
nerve1 / 1576863
ovary7 / 10205168
pancreas19 / 21481288
parathyroid0 / 205390 
pharynx17 / 41328411
pituitary gland3 / 16585180
placenta21 / 28082574
prostate7 / 18934536
salivary gland1 / 2015549
skin8 / 21057437
spleen9 / 53952166
stomach6 / 9661962
testis40 / 330442121
thymus8 / 8113198
thyroid5 / 47473105
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord5 / 13680365
uterus27 / 232878115
vascular29 / 51780560
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212387_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.05
Adipocyte5.3
AdrenalCortex5.5
Adrenalgland4.35
Amygdala18.6
Appendix5.3
AtrioventricularNode4
BDCA4+_DentriticCells531.1
Bonemarrow4.05
BronchialEpithelialCells3.95
CD105+_Endothelial10.9
CD14+_Monocytes5.8
CD19+_BCells(neg._sel.)149.9
CD33+_Myeloid6.85
CD34+86.75
CD4+_Tcells4.4
CD56+_NKCells6.45
CD71+_EarlyErythroid4.65
CD8+_Tcells3.85
CardiacMyocytes6.05
Caudatenucleus5.95
Cerebellum8.75
CerebellumPeduncles10.35
CiliaryGanglion3.5
CingulateCortex17.25
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.95
FetalThyroid5.2
Fetalbrain164.05
Fetalliver3.45
Fetallung6.8
GlobusPallidus9.35
Heart5.15
Hypothalamus7.65
Kidney3.8
Leukemia_chronicMyelogenousK-5624.7
Leukemia_promyelocytic-HL-606.55
Leukemialymphoblastic(MOLT-4)3.25
Liver5.35
Lung4.9
Lymphnode5.8
Lymphoma_burkitts(Daudi)7.6
Lymphoma_burkitts(Raji)9.45
MedullaOblongata5.8
OccipitalLobe18.65
OlfactoryBulb10.3
Ovary3.4
Pancreas3.6
PancreaticIslet5
ParietalLobe9.4
Pituitary6.45
Placenta4.3
Pons7.05
PrefrontalCortex231.65
Prostate6
Salivarygland4.35
SkeletalMuscle5.3
Skin4.1
SmoothMuscle6.1
Spinalcord7.55
SubthalamicNucleus8.8
SuperiorCervicalGanglion5.25
TemporalLobe11.05
Testis3.45
TestisGermCell5.55
TestisIntersitial4.25
TestisLeydigCell4
TestisSeminiferousTubule4.1
Thalamus5.3
Thymus3.25
Thyroid6.75
Tongue5.2
Tonsil6.45
Trachea5
TrigeminalGanglion5.1
Uterus25.05
UterusCorpus4.6
WholeBlood4.4
Wholebrain6.4
colon5.3
pineal_day27.94
pineal_night24.28
retina7.05
small_intestine5.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P931428
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.72 ± 0.37
Basal Forebrain8.22 ± 0.15
Basal Part of Pons8.76 ± 0.27
Cerebellar Cortex8.96 ± 0.12
Cerebellar Nuclei8.23 ± 0.48
Claustrum8.38 ± 0.31
Epithalamus8.21 ± 0.29
Frontal Lobe8.55 ± 0.36
Globus Pallidus7.99 ± 0.3
Hypothalamus8.1 ± 0.35
Insula8.82 ± 0.3
Limbic Lobe8.95 ± 0.37
Mesencephalon8.3 ± 0.37
Myelencephalon8.51 ± 0.42
Occipital Lobe8.62 ± 0.45
Parietal Lobe8.63 ± 0.34
Pontine Tegmentum8.42 ± 0.44
Striatum7.65 ± 0.43
Subthalamus8.21 ± 0.15
Temporal Lobe8.68 ± 0.31
Thalamus8.15 ± 0.33
White Matter8.56 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tcf4CBCerebellum26.27
34.84
Tcf4CTXCerebral cortex81.54
75.34
Tcf4HIPHippocampal region95.71
100
Tcf4HPFHippocampal formation99.13
100
Tcf4HYHypothalamus25.53
24.48
Tcf4LSXLateral septal complex41.19
42.89
Tcf4MBMidbrain19.28
21.88
Tcf4MYMedulla13.41
17.83
Tcf4OLFOlfactory bulb87
81.28
Tcf4PPons19.65
26.59
Tcf4PALPallidum34.03
38.95
Tcf4RHPRetrohippocampal region100
100
Tcf4sAMYStriatum-like amygdalar nuclei47.12
45.73
Tcf4STRStriatum41.4
41.69
Tcf4STRdStriatum dorsal region40.79
40.74
Tcf4STRvStriatum ventral region35.57
39.11
Tcf4THThalamus23.69
25.62
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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