AutismKB 2.0

Annotation Detail for TBX3


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Basic Information Top
Gene Symbol:TBX3 ( TBX3-ISO,UMS,XHL )
Gene Full Name: T-box 3
Band: 12q24.21
Quick LinksEntrez ID:6926; OMIM: 601621; Uniprot ID:TBX3_HUMAN; ENSEMBL ID: ENSG00000135111; HGNC ID: 11602
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst0 / 623190 
fetus31 / 56401254
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult151 / 193912177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor4 / 26384515
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal214 / 336030763
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer19 / 102680185
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland13 / 33197391
ascites1 / 4001524
bladder2 / 2975767
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain7 / 11009896
cervix3 / 4817162
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye3 / 21105414
heart4 / 8962644
intestine10 / 23447242
kidney12 / 21177756
larynx0 / 241450 
liver1 / 2077434
lung21 / 33697462
lymph0 / 442700 
lymph node2 / 9161021
mammary gland8 / 15327152
mouth0 / 670520 
muscle0 / 1077150 
nerve2 / 15768126
ovary1 / 1020519
pancreas2 / 2148129
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta84 / 280825299
prostate41 / 189345216
salivary gland0 / 201550 
skin9 / 21057442
spleen0 / 539520 
stomach2 / 9661920
testis1 / 3304423
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus8 / 23287834
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219682_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.2
Adipocyte14.45
AdrenalCortex235.55
Adrenalgland639.3
Amygdala7.5
Appendix9
AtrioventricularNode7.05
BDCA4+_DentriticCells6.45
Bonemarrow8.15
BronchialEpithelialCells7
CD105+_Endothelial7.4
CD14+_Monocytes7.9
CD19+_BCells(neg._sel.)7.3
CD33+_Myeloid9.35
CD34+8.7
CD4+_Tcells7.7
CD56+_NKCells8.15
CD71+_EarlyErythroid7
CD8+_Tcells6.3
CardiacMyocytes16.4
Caudatenucleus6.65
Cerebellum6.05
CerebellumPeduncles8.9
CiliaryGanglion8.7
CingulateCortex7.8
Colorectaladenocarcinoma13.85
DorsalRootGanglion7
FetalThyroid16.5
Fetalbrain7.5
Fetalliver6.8
Fetallung28.75
GlobusPallidus5.9
Heart11.6
Hypothalamus8.05
Kidney6.75
Leukemia_chronicMyelogenousK-5626.75
Leukemia_promyelocytic-HL-606.7
Leukemialymphoblastic(MOLT-4)5.85
Liver13.1
Lung22.65
Lymphnode6.2
Lymphoma_burkitts(Daudi)9.9
Lymphoma_burkitts(Raji)10.8
MedullaOblongata6.85
OccipitalLobe6.7
OlfactoryBulb6.1
Ovary9.7
Pancreas9.95
PancreaticIslet8.2
ParietalLobe8.4
Pituitary10.65
Placenta572.4
Pons9.35
PrefrontalCortex8.65
Prostate328
Salivarygland7.55
SkeletalMuscle10.75
Skin6.65
SmoothMuscle11.7
Spinalcord8
SubthalamicNucleus7.2
SuperiorCervicalGanglion20.55
TemporalLobe7.15
Testis6.65
TestisGermCell6.3
TestisIntersitial6.35
TestisLeydigCell9.1
TestisSeminiferousTubule6.3
Thalamus7.85
Thymus5.8
Thyroid197.7
Tongue8.6
Tonsil7.55
Trachea18.1
TrigeminalGanglion10.8
Uterus17.4
UterusCorpus8.8
WholeBlood7.95
Wholebrain5.95
colon7.85
pineal_day8.82
pineal_night8.82
retina13.275
small_intestine66.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P13772
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.63 ± 0.64
Basal Forebrain2.79 ± 0.6
Basal Part of Pons2.76 ± 0.63
Cerebellar Cortex2.47 ± 0.56
Cerebellar Nuclei3.54 ± 0.63
Claustrum2.64 ± 0.56
Epithalamus2.77 ± 0.88
Frontal Lobe2.86 ± 0.8
Globus Pallidus4.14 ± 0.53
Hypothalamus3.32 ± 0.86
Insula2.9 ± 0.7
Limbic Lobe2.63 ± 0.77
Mesencephalon2.91 ± 0.74
Myelencephalon2.99 ± 0.74
Occipital Lobe3.04 ± 0.82
Parietal Lobe2.76 ± 0.67
Pontine Tegmentum2.81 ± 0.71
Striatum3.54 ± 0.72
Subthalamus3.54 ± 0.59
Temporal Lobe2.66 ± 0.66
Thalamus3.15 ± 0.64
White Matter2.89 ± 0.84
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tbx3CBCerebellum74.9
100
Tbx3CTXCerebral cortex59.39
38.38
Tbx3HIPHippocampal region28.34
22.92
Tbx3HPFHippocampal formation44.27
35.43
Tbx3HYHypothalamus31.32
23.55
Tbx3LSXLateral septal complex4.41
2.53
Tbx3MBMidbrain27.98
20.87
Tbx3MYMedulla42.89
37.79
Tbx3OLFOlfactory bulb76.61
61.43
Tbx3PPons31.25
27.54
Tbx3PALPallidum34.47
30.09
Tbx3RHPRetrohippocampal region71.35
52.93
Tbx3sAMYStriatum-like amygdalar nuclei25.8
16.77
Tbx3STRStriatum33.86
24.89
Tbx3STRdStriatum dorsal region29.49
20.31
Tbx3STRvStriatum ventral region52.6
42.1
Tbx3THThalamus18.71
13.86
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00072515 17 710 726 LCAEKEAATSELQSIQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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