AutismKB 2.0

Annotation Detail for TCF3


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Basic Information Top
Gene Symbol:TCF3 ( E2A,ITF1,MGC129647,MGC129648,VDIR,bHLHb21 )
Gene Full Name: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
Band: 19p13.3
Quick LinksEntrez ID:6929; OMIM: 147141; Uniprot ID:TFE2_HUMAN; ENSEMBL ID: ENSG00000071564; HGNC ID: 11633
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst11 / 62319176
fetus53 / 56401293
neonate0 / 310970 
infant3 / 23620127
juvenile3 / 5555653
adult137 / 193912170
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor4 / 34366116
chondrosarcoma9 / 82823108
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor33 / 263845125
glioma20 / 106883187
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia26 / 95842271
liver tumor10 / 96359103
lung tumor11 / 103127106
lymphoma25 / 71755348
non-neoplasia3 / 9725030
normal260 / 336030777
ovarian tumor21 / 76682273
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer4 / 10268038
retinoblastoma8 / 46356172
skin tumor4 / 12494932
soft tissue/muscle tissue tumor22 / 125191175
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites4 / 4001599
bladder1 / 2975733
blood6 / 12347848
bone5 / 7165569
bone marrow1 / 4880120
brain39 / 110098935
cervix9 / 48171186
connective tissue3 / 14925520
ear1 / 1621261
embryonic tissue35 / 215722162
esophagus0 / 202090 
eye19 / 21105490
heart7 / 8962678
intestine34 / 234472145
kidney11 / 21177751
larynx0 / 241450 
liver14 / 20774367
lung40 / 336974118
lymph17 / 44270384
lymph node67 / 91610731
mammary gland18 / 153271117
mouth1 / 6705214
muscle13 / 107715120
nerve0 / 157680 
ovary24 / 102051235
pancreas17 / 21481279
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta16 / 28082556
prostate7 / 18934536
salivary gland1 / 2015549
skin9 / 21057442
spleen4 / 5395274
stomach7 / 9661972
testis23 / 33044269
thymus4 / 8113149
thyroid0 / 474730 
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord0 / 136800 
uterus20 / 23287885
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210776_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts544.05
Adipocyte44.1
AdrenalCortex49.25
Adrenalgland31.95
Amygdala33.5
Appendix45.2
AtrioventricularNode40.3
BDCA4+_DentriticCells569.9
Bonemarrow87.75
BronchialEpithelialCells65.3
CD105+_Endothelial702.8
CD14+_Monocytes81.75
CD19+_BCells(neg._sel.)597.9
CD33+_Myeloid108.9
CD34+350.55
CD4+_Tcells92.45
CD56+_NKCells114.85
CD71+_EarlyErythroid1097.65
CD8+_Tcells117.8
CardiacMyocytes74.55
Caudatenucleus36.65
Cerebellum40.25
CerebellumPeduncles55.5
CiliaryGanglion33.25
CingulateCortex45.15
Colorectaladenocarcinoma70.65
DorsalRootGanglion35.1
FetalThyroid47.25
Fetalbrain49.6
Fetalliver80.4
Fetallung46.7
GlobusPallidus38.2
Heart58.2
Hypothalamus34.25
Kidney37.1
Leukemia_chronicMyelogenousK-562100.85
Leukemia_promyelocytic-HL-60430.85
Leukemialymphoblastic(MOLT-4)161.9
Liver53.1
Lung52.6
Lymphnode68.75
Lymphoma_burkitts(Daudi)796.55
Lymphoma_burkitts(Raji)509.2
MedullaOblongata38.05
OccipitalLobe40.9
OlfactoryBulb36.7
Ovary30.55
Pancreas43.3
PancreaticIslet48.7
ParietalLobe51.3
Pituitary56.8
Placenta46.25
Pons41.9
PrefrontalCortex46.5
Prostate78.3
Salivarygland35.95
SkeletalMuscle54.25
Skin36.65
SmoothMuscle70.8
Spinalcord29.85
SubthalamicNucleus41.85
SuperiorCervicalGanglion54.5
TemporalLobe40.15
Testis107
TestisGermCell94.25
TestisIntersitial66.6
TestisLeydigCell60.7
TestisSeminiferousTubule116.1
Thalamus30.7
Thymus99.2
Thyroid66.35
Tongue47.55
Tonsil169.7
Trachea40.25
TrigeminalGanglion45.75
Uterus40.4
UterusCorpus42.35
WholeBlood48.5
Wholebrain26.2
colon40.8
pineal_day56.3
pineal_night50.78
retina56.775
small_intestine56.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P367397
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.16 ± 0.41
Basal Forebrain5.04 ± 0.17
Basal Part of Pons4.65 ± 0.42
Cerebellar Cortex4.61 ± 0.32
Cerebellar Nuclei4.63 ± 0.41
Claustrum5.07 ± 0.73
Epithalamus5 ± 0.25
Frontal Lobe4.62 ± 0.44
Globus Pallidus5.48 ± 0.27
Hypothalamus4.53 ± 0.52
Insula4.53 ± 0.42
Limbic Lobe4.84 ± 0.56
Mesencephalon4.82 ± 0.55
Myelencephalon4.9 ± 0.53
Occipital Lobe5.14 ± 0.57
Parietal Lobe4.84 ± 0.47
Pontine Tegmentum4.84 ± 0.55
Striatum5.34 ± 0.45
Subthalamus4.79 ± 0.43
Temporal Lobe4.79 ± 0.45
Thalamus4.83 ± 0.47
White Matter5.63 ± 0.74
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tcfe2aCBCerebellum7.45
7.8
Tcfe2aCTXCerebral cortex8.81
4.07
Tcfe2aHIPHippocampal region8.42
6.11
Tcfe2aHPFHippocampal formation7.81
4.9
Tcfe2aHYHypothalamus2.41
1.18
Tcfe2aLSXLateral septal complex3.53
1.51
Tcfe2aMBMidbrain2.96
2.55
Tcfe2aMYMedulla7.61
7.42
Tcfe2aOLFOlfactory bulb10.19
5.49
Tcfe2aPPons5.89
5.21
Tcfe2aPALPallidum3.69
1.67
Tcfe2aRHPRetrohippocampal region7.64
3.62
Tcfe2asAMYStriatum-like amygdalar nuclei7.13
2.19
Tcfe2aSTRStriatum2.71
1.55
Tcfe2aSTRdStriatum dorsal region1.44
1.15
Tcfe2aSTRvStriatum ventral region4.25
2.04
Tcfe2aTHThalamus3.54
2.22
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00070124 13 393 405 IEDHLDEAIHVLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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