AutismKB 2.0

Annotation Detail for TCF7L2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TCF7L2 ( TCF-4,TCF4 )
Gene Full Name: transcription factor 7-like 2 (T-cell specific, HMG-box)
Band: 10q25.2-q25.3
Quick LinksEntrez ID:6934; OMIM: 602228; Uniprot ID:TF7L2_HUMAN; ENSEMBL ID: ENSG00000148737; HGNC ID: 11641
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus48 / 56401285
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult75 / 193912138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor11 / 94178116
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor4 / 26384515
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor9 / 68959130
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal166 / 336030749
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone4 / 7165555
bone marrow1 / 4880120
brain58 / 110098952
cervix2 / 4817141
connective tissue8 / 14925553
ear3 / 16212185
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye13 / 21105461
heart9 / 89626100
intestine18 / 23447276
kidney14 / 21177766
larynx3 / 24145124
liver2 / 2077439
lung17 / 33697450
lymph0 / 442700 
lymph node0 / 916100 
mammary gland15 / 15327197
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas8 / 21481237
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate3 / 18934515
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach3 / 9661931
testis10 / 33044230
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus10 / 23287842
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216035_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.75
Adipocyte36.35
AdrenalCortex9.25
Adrenalgland7.5
Amygdala10.45
Appendix9.1
AtrioventricularNode8.9
BDCA4+_DentriticCells7.65
Bonemarrow8.5
BronchialEpithelialCells8
CD105+_Endothelial7.45
CD14+_Monocytes15.45
CD19+_BCells(neg._sel.)7.55
CD33+_Myeloid15.05
CD34+10.45
CD4+_Tcells8.65
CD56+_NKCells70.75
CD71+_EarlyErythroid7.65
CD8+_Tcells6.45
CardiacMyocytes21.25
Caudatenucleus10.15
Cerebellum7.15
CerebellumPeduncles9.9
CiliaryGanglion9.25
CingulateCortex15.8
Colorectaladenocarcinoma9.35
DorsalRootGanglion7.05
FetalThyroid8.1
Fetalbrain7.15
Fetalliver11.65
Fetallung17.1
GlobusPallidus6.15
Heart11.25
Hypothalamus225.55
Kidney10.2
Leukemia_chronicMyelogenousK-5627.1
Leukemia_promyelocytic-HL-606.85
Leukemialymphoblastic(MOLT-4)6.75
Liver11.8
Lung27.9
Lymphnode8
Lymphoma_burkitts(Daudi)10.1
Lymphoma_burkitts(Raji)10.9
MedullaOblongata7.35
OccipitalLobe7.3
OlfactoryBulb9.45
Ovary7.3
Pancreas11
PancreaticIslet8.9
ParietalLobe9.25
Pituitary10.25
Placenta24.1
Pons7.1
PrefrontalCortex14.4
Prostate16.1
Salivarygland14.3
SkeletalMuscle10.6
Skin7.35
SmoothMuscle11.75
Spinalcord9.85
SubthalamicNucleus8.55
SuperiorCervicalGanglion11.1
TemporalLobe7.2
Testis8.35
TestisGermCell7.4
TestisIntersitial6.1
TestisLeydigCell8.5
TestisSeminiferousTubule9.55
Thalamus849.65
Thymus7.4
Thyroid13.45
Tongue8.75
Tonsil7.95
Trachea31.2
TrigeminalGanglion9.15
Uterus42.95
UterusCorpus8
WholeBlood10.05
Wholebrain8.05
colon151.8
pineal_day16.26
pineal_night15.3
retina18.025
small_intestine45.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P127013
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.61 ± 1.11
Basal Forebrain1.14 ± 0.23
Basal Part of Pons1.26 ± 0.79
Cerebellar Cortex1.02 ± 0.81
Cerebellar Nuclei1.37 ± 0.73
Claustrum2.35 ± 0.86
Epithalamus2.85 ± 1.12
Frontal Lobe1.89 ± 1.12
Globus Pallidus3.37 ± 1.19
Hypothalamus1.35 ± 0.67
Insula1.65 ± 1.42
Limbic Lobe1.44 ± 0.85
Mesencephalon2.12 ± 1.15
Myelencephalon1.97 ± 1.03
Occipital Lobe2.78 ± 1.35
Parietal Lobe2.11 ± 1.15
Pontine Tegmentum2.09 ± 0.8
Striatum2.26 ± 1.05
Subthalamus0.84 ± 0.43
Temporal Lobe1.66 ± 1.18
Thalamus4.07 ± 1.02
White Matter2.43 ± 1.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tcf7l2CBCerebellum12.51
18.15
Tcf7l2CTXCerebral cortex3.33
3.25
Tcf7l2HIPHippocampal region4.16
5.3
Tcf7l2HPFHippocampal formation3.36
3.93
Tcf7l2HYHypothalamus11.19
13.41
Tcf7l2LSXLateral septal complex3.14
3.64
Tcf7l2MBMidbrain64.51
88.62
Tcf7l2MYMedulla4.44
5.4
Tcf7l2OLFOlfactory bulb5.39
5.02
Tcf7l2PPons2.59
3.25
Tcf7l2PALPallidum10.71
13.25
Tcf7l2RHPRetrohippocampal region2.22
2.19
Tcf7l2sAMYStriatum-like amygdalar nuclei8.11
9.79
Tcf7l2STRStriatum3.28
3.54
Tcf7l2STRdStriatum dorsal region2.16
2.23
Tcf7l2STRvStriatum ventral region4.07
3.88
Tcf7l2THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved