AutismKB 2.0

Annotation Detail for ZEB1


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Basic Information Top
Gene Symbol:ZEB1 ( AREB6,BZP,DELTAEF1,FECD6,MGC133261,NIL2A,TCF8,ZFHEP,ZFHX1A )
Gene Full Name: zinc finger E-box binding homeobox 1
Band: 10p11.22
Quick LinksEntrez ID:6935; OMIM: 189909; Uniprot ID:ZEB1_HUMAN; ENSEMBL ID: ENSG00000148516; HGNC ID: 11642
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus82 / 564012145
neonate5 / 31097160
infant2 / 2362084
juvenile3 / 5555653
adult88 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor4 / 26384515
glioma4 / 10688337
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal244 / 336030772
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood7 / 12347856
bone3 / 7165541
bone marrow1 / 4880120
brain92 / 110098983
cervix0 / 481710 
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye4 / 21105418
heart7 / 8962678
intestine4 / 23447217
kidney7 / 21177733
larynx0 / 241450 
liver13 / 20774362
lung9 / 33697426
lymph0 / 442700 
lymph node4 / 9161043
mammary gland1 / 1532716
mouth4 / 6705259
muscle24 / 107715222
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta15 / 28082553
prostate4 / 18934521
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach6 / 9661962
testis21 / 33044263
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord2 / 13680146
uterus18 / 23287877
vascular10 / 51780193
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210875_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.65
Adipocyte16
AdrenalCortex14.45
Adrenalgland9.45
Amygdala11.15
Appendix16.55
AtrioventricularNode15.15
BDCA4+_DentriticCells9.5
Bonemarrow11.9
BronchialEpithelialCells12.05
CD105+_Endothelial9.75
CD14+_Monocytes10.85
CD19+_BCells(neg._sel.)10.25
CD33+_Myeloid11.95
CD34+11.9
CD4+_Tcells9.8
CD56+_NKCells10.7
CD71+_EarlyErythroid10
CD8+_Tcells8.65
CardiacMyocytes21.65
Caudatenucleus9
Cerebellum8.35
CerebellumPeduncles13.85
CiliaryGanglion12.7
CingulateCortex10.95
Colorectaladenocarcinoma9.8
DorsalRootGanglion10.6
FetalThyroid12.85
Fetalbrain9.6
Fetalliver9.15
Fetallung8.8
GlobusPallidus10.3
Heart18.75
Hypothalamus17.9
Kidney9.85
Leukemia_chronicMyelogenousK-5628.85
Leukemia_promyelocytic-HL-608.65
Leukemialymphoblastic(MOLT-4)7.7
Liver17.2
Lung10.85
Lymphnode8.3
Lymphoma_burkitts(Daudi)13.8
Lymphoma_burkitts(Raji)17
MedullaOblongata8.85
OccipitalLobe9.7
OlfactoryBulb7.8
Ovary10.4
Pancreas9
PancreaticIslet11.65
ParietalLobe12.2
Pituitary11.9
Placenta9.2
Pons10.8
PrefrontalCortex17.4
Prostate11.15
Salivarygland10.05
SkeletalMuscle20.15
Skin11.65
SmoothMuscle13.85
Spinalcord10.1
SubthalamicNucleus14
SuperiorCervicalGanglion20.85
TemporalLobe10.1
Testis8.25
TestisGermCell7.75
TestisIntersitial8.85
TestisLeydigCell11.1
TestisSeminiferousTubule8.5
Thalamus10.95
Thymus7.05
Thyroid11.1
Tongue12.55
Tonsil10.65
Trachea8.1
TrigeminalGanglion15.35
Uterus47.4
UterusCorpus14.1
WholeBlood10.7
Wholebrain7.35
colon9.85
pineal_day12.58
pineal_night12.52
retina12.625
small_intestine9.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P202013
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.59 ± 0.25
Basal Forebrain7.03 ± 0.2
Basal Part of Pons6.52 ± 0.32
Cerebellar Cortex6.38 ± 0.19
Cerebellar Nuclei6.67 ± 0.31
Claustrum6.23 ± 0.43
Epithalamus7.23 ± 0.17
Frontal Lobe6.66 ± 0.29
Globus Pallidus7.31 ± 0.19
Hypothalamus6.88 ± 0.34
Insula6.6 ± 0.32
Limbic Lobe6.55 ± 0.39
Mesencephalon6.84 ± 0.3
Myelencephalon6.76 ± 0.36
Occipital Lobe6.73 ± 0.46
Parietal Lobe6.82 ± 0.37
Pontine Tegmentum6.67 ± 0.47
Striatum6.9 ± 0.37
Subthalamus6.79 ± 0.42
Temporal Lobe6.81 ± 0.31
Thalamus6.92 ± 0.33
White Matter6.28 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfhx1aCBCerebellum78.07
100
Zfhx1aCTXCerebral cortex99.4
73.11
Zfhx1aHIPHippocampal region72.47
100
Zfhx1aHPFHippocampal formation79.53
96.22
Zfhx1aHYHypothalamus82.93
63.86
Zfhx1aLSXLateral septal complex87.84
64.82
Zfhx1aMBMidbrain79.2
70.75
Zfhx1aMYMedulla65.96
67.91
Zfhx1aOLFOlfactory bulb100
100
Zfhx1aPPons62.24
61.87
Zfhx1aPALPallidum77.63
65.63
Zfhx1aRHPRetrohippocampal region92.43
83.16
Zfhx1asAMYStriatum-like amygdalar nuclei82.49
55.47
Zfhx1aSTRStriatum92.95
69.04
Zfhx1aSTRdStriatum dorsal region88.77
65.82
Zfhx1aSTRvStriatum ventral region100
84.67
Zfhx1aTHThalamus71.12
57.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00505216 34 1055 1088 ECEKPQGDEEEEEEEEEVEEEEVEEAENEGEEAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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