AutismKB 2.0

Annotation Detail for TCF12


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Basic Information Top
Gene Symbol:TCF12 ( HEB,HTF4,HsT17266,bHLHb20 )
Gene Full Name: transcription factor 12
Band: 15q21.3
Quick LinksEntrez ID:6938; OMIM: 600480; Uniprot ID:HTF4_HUMAN; ENSEMBL ID: ENSG00000140262; HGNC ID: 11623
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body19 / 70761268
blastocyst8 / 62319128
fetus86 / 564012152
neonate6 / 31097192
infant11 / 23620465
juvenile4 / 5555671
adult174 / 193912189
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor12 / 94178127
cervical tumor5 / 34366145
chondrosarcoma6 / 8282372
colorectal tumor7 / 11424661
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor41 / 263845155
glioma18 / 106883168
head and neck tumor19 / 136302139
kidney tumor7 / 68959101
leukemia6 / 9584262
liver tumor7 / 9635972
lung tumor7 / 10312767
lymphoma1 / 7175513
non-neoplasia10 / 97250102
normal345 / 3360307102
ovarian tumor3 / 7668239
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer7 / 10268068
retinoblastoma8 / 46356172
skin tumor7 / 12494956
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder3 / 29757100
blood6 / 12347848
bone6 / 7165583
bone marrow3 / 4880161
brain157 / 1100989142
cervix6 / 48171124
connective tissue10 / 14925566
ear9 / 16212555
embryonic tissue38 / 215722176
esophagus1 / 2020949
eye25 / 211054118
heart11 / 89626122
intestine15 / 23447263
kidney14 / 21177766
larynx4 / 24145165
liver16 / 20774377
lung24 / 33697471
lymph1 / 4427022
lymph node6 / 9161065
mammary gland13 / 15327184
mouth8 / 67052119
muscle21 / 107715194
nerve0 / 157680 
ovary6 / 10205158
pancreas12 / 21481255
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta15 / 28082553
prostate12 / 18934563
salivary gland0 / 201550 
skin17 / 21057480
spleen4 / 5395274
stomach6 / 9661962
testis51 / 330442154
thymus21 / 81131258
thyroid8 / 47473168
tonsil0 / 169990 
trachea24 / 52413457
umbilical cord1 / 1368073
uterus39 / 232878167
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208986_at
Cell line Expression level Expression bar
721_B_lymphoblasts81.05
Adipocyte19.95
AdrenalCortex14.65
Adrenalgland12.65
Amygdala55.7
Appendix30.05
AtrioventricularNode11.3
BDCA4+_DentriticCells35.5
Bonemarrow11.25
BronchialEpithelialCells29.85
CD105+_Endothelial59.1
CD14+_Monocytes27.5
CD19+_BCells(neg._sel.)61.4
CD33+_Myeloid21.7
CD34+49.5
CD4+_Tcells20.2
CD56+_NKCells47.1
CD71+_EarlyErythroid19.85
CD8+_Tcells22.7
CardiacMyocytes29.8
Caudatenucleus30.4
Cerebellum12.2
CerebellumPeduncles18.15
CiliaryGanglion12.45
CingulateCortex17.2
Colorectaladenocarcinoma30.2
DorsalRootGanglion13.8
FetalThyroid41.35
Fetalbrain76.2
Fetalliver26.9
Fetallung76.7
GlobusPallidus8.15
Heart14.8
Hypothalamus66.9
Kidney9.9
Leukemia_chronicMyelogenousK-56242.2
Leukemia_promyelocytic-HL-6027.5
Leukemialymphoblastic(MOLT-4)131.35
Liver9.95
Lung16.15
Lymphnode35.2
Lymphoma_burkitts(Daudi)33.55
Lymphoma_burkitts(Raji)63.95
MedullaOblongata20.5
OccipitalLobe26.8
OlfactoryBulb41.2
Ovary11.15
Pancreas18.6
PancreaticIslet21.75
ParietalLobe17.75
Pituitary18.65
Placenta21.8
Pons13.1
PrefrontalCortex55.55
Prostate51.6
Salivarygland17.85
SkeletalMuscle7.8
Skin14.95
SmoothMuscle63.3
Spinalcord55.95
SubthalamicNucleus14.1
SuperiorCervicalGanglion26.7
TemporalLobe9.75
Testis13.55
TestisGermCell28.75
TestisIntersitial15.2
TestisLeydigCell25.6
TestisSeminiferousTubule23.9
Thalamus20.5
Thymus173.55
Thyroid102.4
Tongue19.65
Tonsil15.2
Trachea23.1
TrigeminalGanglion18
Uterus148.3
UterusCorpus14.6
WholeBlood19.25
Wholebrain15.9
colon64.85
pineal_day109.94
pineal_night110.66
retina39.125
small_intestine43.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P151930
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.78 ± 0.32
Basal Forebrain9.14 ± 0.34
Basal Part of Pons8.62 ± 0.29
Cerebellar Cortex8.91 ± 0.19
Cerebellar Nuclei9.35 ± 0.4
Claustrum8.58 ± 0.44
Epithalamus9.19 ± 0.24
Frontal Lobe8.82 ± 0.41
Globus Pallidus10.08 ± 0.28
Hypothalamus8.66 ± 0.26
Insula8.75 ± 0.3
Limbic Lobe8.98 ± 0.38
Mesencephalon9.18 ± 0.35
Myelencephalon9.03 ± 0.42
Occipital Lobe9.21 ± 0.47
Parietal Lobe8.88 ± 0.35
Pontine Tegmentum9.11 ± 0.44
Striatum9.47 ± 0.5
Subthalamus8.93 ± 0.12
Temporal Lobe8.82 ± 0.29
Thalamus9.16 ± 0.27
White Matter10.45 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tcf12CBCerebellum25.38
41.98
Tcf12CTXCerebral cortex22.1
15.54
Tcf12HIPHippocampal region34.99
45.38
Tcf12HPFHippocampal formation28.09
31.43
Tcf12HYHypothalamus6.52
5.01
Tcf12LSXLateral septal complex53
48.17
Tcf12MBMidbrain9.04
7.94
Tcf12MYMedulla21.92
20.77
Tcf12OLFOlfactory bulb34.62
29.3
Tcf12PPons19.1
18.62
Tcf12PALPallidum7.94
6.48
Tcf12RHPRetrohippocampal region16.43
13.11
Tcf12sAMYStriatum-like amygdalar nuclei19.23
13.77
Tcf12STRStriatum16.48
13.34
Tcf12STRdStriatum dorsal region13.56
11.29
Tcf12STRvStriatum ventral region13.69
9.38
Tcf12THThalamus8.34
7.23
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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