AutismKB 2.0

Annotation Detail for TCF21


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Basic Information Top
Gene Symbol:TCF21 ( POD1,bHLHa23 )
Gene Full Name: transcription factor 21
Band: 6q23.2
Quick LinksEntrez ID:6943; OMIM: 603306; Uniprot ID:TCF21_HUMAN; ENSEMBL ID: ENSG00000118526; HGNC ID: 11632
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus27 / 56401247
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult63 / 193912132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma17 / 82823205
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal104 / 336030730
ovarian tumor7 / 7668291
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine5 / 23447221
kidney12 / 21177756
larynx0 / 241450 
liver1 / 2077434
lung29 / 33697486
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary10 / 10205197
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta31 / 280825110
prostate3 / 18934515
salivary gland0 / 201550 
skin1 / 2105744
spleen3 / 5395255
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204931_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.25
Adipocyte5.25
AdrenalCortex6.4
Adrenalgland4.65
Amygdala5.45
Appendix5.9
AtrioventricularNode4.6
BDCA4+_DentriticCells5.45
Bonemarrow5.6
BronchialEpithelialCells5.15
CD105+_Endothelial5.45
CD14+_Monocytes5.7
CD19+_BCells(neg._sel.)5.6
CD33+_Myeloid6.95
CD34+6.4
CD4+_Tcells5.5
CD56+_NKCells6.05
CD71+_EarlyErythroid5.05
CD8+_Tcells4.9
CardiacMyocytes12.5
Caudatenucleus4.9
Cerebellum4.4
CerebellumPeduncles6.1
CiliaryGanglion4.15
CingulateCortex5.55
Colorectaladenocarcinoma5.35
DorsalRootGanglion4.4
FetalThyroid5.2
Fetalbrain5.3
Fetalliver4.8
Fetallung499.6
GlobusPallidus4
Heart26.6
Hypothalamus5.75
Kidney15.65
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.8
Leukemialymphoblastic(MOLT-4)4.3
Liver7.85
Lung589.1
Lymphnode4.65
Lymphoma_burkitts(Daudi)6.95
Lymphoma_burkitts(Raji)7.95
MedullaOblongata4.8
OccipitalLobe4.8
OlfactoryBulb4.2
Ovary3.8
Pancreas4.45
PancreaticIslet5.8
ParietalLobe5.8
Pituitary6.2
Placenta231.05
Pons5.15
PrefrontalCortex6.7
Prostate15.95
Salivarygland4.35
SkeletalMuscle7.55
Skin4.4
SmoothMuscle21.95
Spinalcord5.7
SubthalamicNucleus5.05
SuperiorCervicalGanglion6.8
TemporalLobe4.95
Testis4.6
TestisGermCell4.8
TestisIntersitial4.55
TestisLeydigCell5.5
TestisSeminiferousTubule4.65
Thalamus5.5
Thymus4.15
Thyroid6.55
Tongue5.8
Tonsil5.25
Trachea4.55
TrigeminalGanglion5.85
Uterus8.65
UterusCorpus5.05
WholeBlood5.8
Wholebrain4.45
colon23.75
pineal_day6.52
pineal_night6.54
retina6.425
small_intestine31.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P156890
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.38 ± 1.06
Basal Forebrain1.92 ± 0.19
Basal Part of Pons1.57 ± 0.45
Cerebellar Cortex1.7 ± 0.63
Cerebellar Nuclei2.26 ± 0.81
Claustrum2.87 ± 0.92
Epithalamus1.62 ± 0.79
Frontal Lobe1.75 ± 0.7
Globus Pallidus2.64 ± 0.8
Hypothalamus2.07 ± 0.64
Insula1.58 ± 0.47
Limbic Lobe1.86 ± 0.61
Mesencephalon2.19 ± 0.87
Myelencephalon1.94 ± 0.72
Occipital Lobe2.01 ± 0.66
Parietal Lobe2.05 ± 1.01
Pontine Tegmentum1.89 ± 0.61
Striatum1.98 ± 0.5
Subthalamus1.99 ± 0.66
Temporal Lobe1.84 ± 0.68
Thalamus1.9 ± 0.69
White Matter2.18 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tcf21STRdStriatum dorsal region1.06
1.34
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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