AutismKB 2.0

Annotation Detail for TCN2


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Basic Information Top
Gene Symbol:TCN2 ( D22S676,D22S750,II,TC,TC II,TC-2,TC2,TCII )
Gene Full Name: transcobalamin II
Band: 22q12.2
Quick LinksEntrez ID:6948; OMIM: 613441; Uniprot ID:TCO2_HUMAN; ENSEMBL ID: ENSG00000185339; HGNC ID: 11653
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult72 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor12 / 26384545
glioma7 / 10688365
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal92 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor6 / 12494948
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood4 / 12347832
bone0 / 716550 
bone marrow6 / 48801122
brain17 / 110098915
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye9 / 21105442
heart1 / 8962611
intestine7 / 23447229
kidney8 / 21177737
larynx0 / 241450 
liver0 / 2077430 
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland8 / 15327152
mouth6 / 6705289
muscle1 / 1077159
nerve0 / 157680 
ovary4 / 10205139
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta15 / 28082553
prostate1 / 1893455
salivary gland0 / 201550 
skin6 / 21057428
spleen2 / 5395237
stomach3 / 9661931
testis7 / 33044221
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204043_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.35
Adipocyte4.8
AdrenalCortex4.85
Adrenalgland5.55
Amygdala5.05
Appendix4.8
AtrioventricularNode3.75
BDCA4+_DentriticCells5.55
Bonemarrow4.7
BronchialEpithelialCells4.6
CD105+_Endothelial4.95
CD14+_Monocytes12.9
CD19+_BCells(neg._sel.)5.2
CD33+_Myeloid8.3
CD34+5.75
CD4+_Tcells5.4
CD56+_NKCells5.7
CD71+_EarlyErythroid4.45
CD8+_Tcells4.75
CardiacMyocytes5.95
Caudatenucleus4.35
Cerebellum3.9
CerebellumPeduncles5.45
CiliaryGanglion4.15
CingulateCortex4.85
Colorectaladenocarcinoma4.85
DorsalRootGanglion3.6
FetalThyroid4.7
Fetalbrain4.85
Fetalliver4.1
Fetallung4.1
GlobusPallidus4.45
Heart6.05
Hypothalamus5.35
Kidney52.1
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.2
Leukemialymphoblastic(MOLT-4)3.9
Liver6.25
Lung8.5
Lymphnode4.2
Lymphoma_burkitts(Daudi)6.15
Lymphoma_burkitts(Raji)6.6
MedullaOblongata4.45
OccipitalLobe4.35
OlfactoryBulb4.1
Ovary3.15
Pancreas3.85
PancreaticIslet5.15
ParietalLobe5
Pituitary5.6
Placenta5.05
Pons4.55
PrefrontalCortex6.2
Prostate5.75
Salivarygland3.8
SkeletalMuscle5.35
Skin3.65
SmoothMuscle5.45
Spinalcord5.2
SubthalamicNucleus4.3
SuperiorCervicalGanglion5.3
TemporalLobe4.4
Testis4.2
TestisGermCell4.1
TestisIntersitial4
TestisLeydigCell4.75
TestisSeminiferousTubule4.25
Thalamus5
Thymus3.85
Thyroid6.4
Tongue4.6
Tonsil4.6
Trachea4.1
TrigeminalGanglion4.65
Uterus4
UterusCorpus4.25
WholeBlood5.2
Wholebrain4
colon4.75
pineal_day7.66
pineal_night8.98
retina5.925
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P40611
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.8 ± 0.7
Basal Forebrain3.05 ± 0.42
Basal Part of Pons2.47 ± 0.41
Cerebellar Cortex2.67 ± 0.6
Cerebellar Nuclei3.64 ± 0.7
Claustrum2.93 ± 0.6
Epithalamus3.22 ± 0.54
Frontal Lobe3.01 ± 0.65
Globus Pallidus4.19 ± 0.39
Hypothalamus3.23 ± 0.66
Insula3.17 ± 0.56
Limbic Lobe2.81 ± 0.77
Mesencephalon3.32 ± 0.76
Myelencephalon3.19 ± 0.64
Occipital Lobe3.38 ± 0.58
Parietal Lobe2.85 ± 0.74
Pontine Tegmentum3.15 ± 0.61
Striatum3.63 ± 0.5
Subthalamus3.62 ± 0.62
Temporal Lobe2.95 ± 0.68
Thalamus3.34 ± 0.66
White Matter3.92 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tcn2CBCerebellum4.29
7.36
Tcn2CTXCerebral cortex2.42
2.94
Tcn2HIPHippocampal region5.14
9.02
Tcn2HPFHippocampal formation3.34
5.4
Tcn2HYHypothalamus0.93
1.23
Tcn2LSXLateral septal complex3.03
5.88
Tcn2MBMidbrain1.14
1.84
Tcn2MYMedulla6.69
10.53
Tcn2OLFOlfactory bulb5.45
5.17
Tcn2PPons0.84
1.45
Tcn2PALPallidum1.62
1.69
Tcn2RHPRetrohippocampal region0.75
0.96
Tcn2sAMYStriatum-like amygdalar nuclei1.11
1.66
Tcn2STRStriatum4.28
6.28
Tcn2STRdStriatum dorsal region5.83
8.7
Tcn2STRvStriatum ventral region0.68
0.7
Tcn2THThalamus3.12
4.62
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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