AutismKB 2.0

Annotation Detail for DYNLT1


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Basic Information Top
Gene Symbol:DYNLT1 ( CW-1,MGC111571,TCTEL1,tctex-1 )
Gene Full Name: dynein, light chain, Tctex-type 1
Band: 6q25.3
Quick LinksEntrez ID:6993; OMIM: 601554; Uniprot ID:DYLT1_HUMAN; ENSEMBL ID: ENSG00000146425; HGNC ID: 11697
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst1 / 6231916
fetus79 / 564012140
neonate4 / 31097128
infant2 / 2362084
juvenile3 / 5555653
adult147 / 193912175
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor12 / 119369100
germ cell tumor3 / 26384511
glioma10 / 10688393
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia5 / 9584252
liver tumor6 / 9635962
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal343 / 3360307102
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland6 / 33197180
ascites0 / 400150 
bladder2 / 2975767
blood17 / 123478137
bone11 / 71655153
bone marrow7 / 48801143
brain33 / 110098929
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye9 / 21105442
heart19 / 89626211
intestine17 / 23447272
kidney9 / 21177742
larynx0 / 241450 
liver16 / 20774377
lung52 / 336974154
lymph0 / 442700 
lymph node10 / 91610109
mammary gland11 / 15327171
mouth2 / 6705229
muscle5 / 10771546
nerve1 / 1576863
ovary2 / 10205119
pancreas19 / 21481288
parathyroid10 / 20539486
pharynx4 / 4132896
pituitary gland4 / 16585241
placenta24 / 28082585
prostate3 / 18934515
salivary gland0 / 201550 
skin38 / 210574180
spleen2 / 5395237
stomach6 / 9661962
testis31 / 33044293
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord4 / 13680292
uterus36 / 232878154
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201999_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts237
Adipocyte269.95
AdrenalCortex67.25
Adrenalgland113.3
Amygdala46.75
Appendix70.25
AtrioventricularNode23.9
BDCA4+_DentriticCells258.6
Bonemarrow114.15
BronchialEpithelialCells786.85
CD105+_Endothelial256.8
CD14+_Monocytes918.25
CD19+_BCells(neg._sel.)97.25
CD33+_Myeloid529.1
CD34+269.65
CD4+_Tcells788
CD56+_NKCells488.2
CD71+_EarlyErythroid165.35
CD8+_Tcells640.2
CardiacMyocytes511.8
Caudatenucleus36.1
Cerebellum18.4
CerebellumPeduncles18.25
CiliaryGanglion35.05
CingulateCortex12.7
Colorectaladenocarcinoma95.2
DorsalRootGanglion25.55
FetalThyroid563.5
Fetalbrain313
Fetalliver60.75
Fetallung572.45
GlobusPallidus8.85
Heart81.2
Hypothalamus107
Kidney158.45
Leukemia_chronicMyelogenousK-562246.9
Leukemia_promyelocytic-HL-60106.55
Leukemialymphoblastic(MOLT-4)16.15
Liver47.6
Lung329
Lymphnode209.9
Lymphoma_burkitts(Daudi)148.85
Lymphoma_burkitts(Raji)227.05
MedullaOblongata12.7
OccipitalLobe24.3
OlfactoryBulb108.65
Ovary80.75
Pancreas88.65
PancreaticIslet289.1
ParietalLobe23.2
Pituitary189.15
Placenta378.65
Pons12.2
PrefrontalCortex52.65
Prostate415.45
Salivarygland135.9
SkeletalMuscle27.8
Skin31.6
SmoothMuscle838.25
Spinalcord128.85
SubthalamicNucleus15.5
SuperiorCervicalGanglion18.45
TemporalLobe16.35
Testis770.95
TestisGermCell742
TestisIntersitial532.85
TestisLeydigCell402.65
TestisSeminiferousTubule476.9
Thalamus35.1
Thymus129.15
Thyroid506.45
Tongue166.6
Tonsil168.6
Trachea280.5
TrigeminalGanglion17.9
Uterus218.6
UterusCorpus183.7
WholeBlood1024.65
Wholebrain51.8
colon282.75
pineal_day96.72
pineal_night95.7
retina209.9
small_intestine354
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P174680
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.21 ± 1.05
Basal Forebrain1.79 ± 0.61
Basal Part of Pons1.45 ± 0.74
Cerebellar Cortex1.97 ± 0.88
Cerebellar Nuclei1.9 ± 0.8
Claustrum2.77 ± 0.85
Epithalamus1.88 ± 0.69
Frontal Lobe1.58 ± 0.74
Globus Pallidus2.05 ± 0.67
Hypothalamus1.7 ± 0.65
Insula1.38 ± 0.46
Limbic Lobe1.86 ± 0.72
Mesencephalon1.96 ± 0.87
Myelencephalon1.82 ± 0.7
Occipital Lobe2.14 ± 0.8
Parietal Lobe1.78 ± 0.85
Pontine Tegmentum1.95 ± 0.77
Striatum2.02 ± 0.82
Subthalamus1.7 ± 0.64
Temporal Lobe1.72 ± 0.74
Thalamus1.66 ± 0.63
White Matter1.87 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dynlt1CBCerebellum43.73
59.38
Dynlt1CTXCerebral cortex28.75
23.31
Dynlt1HIPHippocampal region17.59
23.94
Dynlt1HPFHippocampal formation16.53
18.77
Dynlt1HYHypothalamus28.91
25.02
Dynlt1LSXLateral septal complex16.02
12.61
Dynlt1MBMidbrain28.8
25.66
Dynlt1MYMedulla24.82
26.89
Dynlt1OLFOlfactory bulb31.81
31.94
Dynlt1PPons23.57
24.53
Dynlt1PALPallidum26.54
23.95
Dynlt1RHPRetrohippocampal region15.08
11.73
Dynlt1sAMYStriatum-like amygdalar nuclei16.87
12.45
Dynlt1STRStriatum18.2
15.14
Dynlt1STRdStriatum dorsal region14.91
13.29
Dynlt1STRvStriatum ventral region33.16
24.72
Dynlt1THThalamus20.41
19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DYLT1_HUMAN_22 16 22 37 EAIESAIGGNAYQHSK PRIDE
DYLT1_HUMAN_38 18 38 55 VNQWTTNVVEQTLSQLTK PRIDE
DYLT1_HUMAN_62 10 62 71 YIVTCVIMQK PRIDE
PAp00041900 24 73 96 NGAGLHTASSCFWDSSTDGSCTVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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