Annotation Detail for TDO2
Basic Information Top
| Gene Symbol: | TDO2 ( TDO,TPH2,TRPO ) |
|---|---|
| Gene Full Name: | tryptophan 2,3-dioxygenase |
| Band: | 4q32.1 |
| Quick Links | Entrez ID:6999; OMIM: 191070; Uniprot ID:T23O_HUMAN; ENSEMBL ID: ENSG00000151790; HGNC ID: 11708 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.183671
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 1 / 70761 | 14 |  |
| blastocyst | 1 / 62319 | 16 | |
| fetus | 22 / 564012 | 39 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 52 / 1939121 | 26 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 3 / 17475 | 171 |  |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 |  |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 13 / 96359 | 134 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 120 / 3360307 | 35 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 7 / 124949 | 56 | |
| soft tissue/muscle tissue tumor | 3 / 125191 | 23 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 3 / 29757 | 100 | |
| blood | 2 / 123478 | 16 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 2 / 1100989 | 1 |  |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 2 / 215722 | 9 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 3 / 89626 | 33 | |
| intestine | 1 / 234472 | 4 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 95 / 207743 | 457 |  |
| lung | 2 / 336974 | 5 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 2 / 153271 | 13 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 3 / 107715 | 27 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 7 / 210574 | 33 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 1 / 330442 | 3 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 205943_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 4.6 | |
| Adipocyte | 3.7 | |
| AdrenalCortex | 3.85 | |
| Adrenalgland | 3.15 | |
| Amygdala | 4 | |
| Appendix | 4.65 | |
| AtrioventricularNode | 2.9 | |
| BDCA4+_DentriticCells | 4.05 | |
| Bonemarrow | 3.7 | |
| BronchialEpithelialCells | 3.65 | |
| CD105+_Endothelial | 3.75 | |
| CD14+_Monocytes | 3.95 | |
| CD19+_BCells(neg._sel.) | 3.95 | |
| CD33+_Myeloid | 4.75 | |
| CD34+ | 4.65 | |
| CD4+_Tcells | 4 | |
| CD56+_NKCells | 4.45 | |
| CD71+_EarlyErythroid | 3.5 | |
| CD8+_Tcells | 3.6 | |
| CardiacMyocytes | 4.85 | |
| Caudatenucleus | 3.65 | |
| Cerebellum | 3.65 | |
| CerebellumPeduncles | 4.3 | |
| CiliaryGanglion | 2.6 | |
| CingulateCortex | 3.85 | |
| Colorectaladenocarcinoma | 3.7 | |
| DorsalRootGanglion | 3 | |
| FetalThyroid | 3.6 | |
| Fetalbrain | 3.75 | |
| Fetalliver | 253.55 | |
| Fetallung | 49.1 | |
| GlobusPallidus | 2.85 | |
| Heart | 5.05 | |
| Hypothalamus | 4.15 | |
| Kidney | 3.1 | |
| Leukemia_chronicMyelogenousK-562 | 42.7 | |
| Leukemia_promyelocytic-HL-60 | 3.3 | |
| Leukemialymphoblastic(MOLT-4) | 3 | |
| Liver | 144.85 | |
| Lung | 4.1 | |
| Lymphnode | 3.25 | |
| Lymphoma_burkitts(Daudi) | 4.7 | |
| Lymphoma_burkitts(Raji) | 5.2 | |
| MedullaOblongata | 5.35 | |
| OccipitalLobe | 3.35 | |
| OlfactoryBulb | 2.95 | |
| Ovary | 2.55 | |
| Pancreas | 3.1 | |
| PancreaticIslet | 4.15 | |
| ParietalLobe | 4.75 | |
| Pituitary | 7.3 | |
| Placenta | 3.85 | |
| Pons | 14.25 | |
| PrefrontalCortex | 4.7 | |
| Prostate | 4.35 | |
| Salivarygland | 3.1 | |
| SkeletalMuscle | 6.25 | |
| Skin | 2.85 | |
| SmoothMuscle | 4.2 | |
| Spinalcord | 4 | |
| SubthalamicNucleus | 3.5 | |
| SuperiorCervicalGanglion | 5.2 | |
| TemporalLobe | 5.2 | |
| Testis | 3.2 | |
| TestisGermCell | 3.1 | |
| TestisIntersitial | 3.15 | |
| TestisLeydigCell | 3.7 | |
| TestisSeminiferousTubule | 3.25 | |
| Thalamus | 3.8 | |
| Thymus | 2.9 | |
| Thyroid | 4.7 | |
| Tongue | 3.75 | |
| Tonsil | 3.6 | |
| Trachea | 3.1 | |
| TrigeminalGanglion | 3.85 | |
| Uterus | 3.05 | |
| UterusCorpus | 3.95 | |
| WholeBlood | 4.2 | |
| Wholebrain | 3.2 | |
| colon | 3.75 | |
| pineal_day | 4.64 | |
| pineal_night | 4.56 | |
| retina | 4.575 | |
| small_intestine | 3.6 | |
- Probe name: CUST_7921_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.23 ± 1.02 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 1.65 ± 0.24 | |
| Basal Part of Pons | 1.54 ± 0.34 | |
| Cerebellar Cortex | 1.58 ± 0.69 | |
| Cerebellar Nuclei | 2 ± 0.67 | |
| Claustrum | 2.91 ± 0.8 | |
| Epithalamus | 1.57 ± 0.74 | |
| Frontal Lobe | 2.13 ± 0.99 | |
| Globus Pallidus | 2.16 ± 0.54 | |
| Hypothalamus | 1.82 ± 0.77 | |
| Insula | 1.59 ± 0.58 | |
| Limbic Lobe | 2.1 ± 0.9 | |
| Mesencephalon | 2.07 ± 0.91 | |
| Myelencephalon | 1.9 ± 0.71 | |
| Occipital Lobe | 1.63 ± 0.66 | |
| Parietal Lobe | 2.23 ± 0.81 | |
| Pontine Tegmentum | 2.08 ± 0.95 | |
| Striatum | 1.71 ± 0.63 | |
| Subthalamus | 2.15 ± 0.29 | |
| Temporal Lobe | 1.7 ± 0.77 | |
| Thalamus | 1.88 ± 0.77 | |
| White Matter | 1.84 ± 0.36 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Tdo2 | CB | Cerebellum | 6.51 | |
| 8.25 | | |||
| Tdo2 | CTX | Cerebral cortex | 1.79 | |
| 1.8 | | |||
| Tdo2 | HIP | Hippocampal region | 14.35 | |
| 32.69 | | |||
| Tdo2 | HPF | Hippocampal formation | 9.51 | |
| 19.02 | | |||
| Tdo2 | HY | Hypothalamus | 0.17 | |
| 0.2 | | |||
| Tdo2 | LSX | Lateral septal complex | 0.5 | |
| 0.48 | | |||
| Tdo2 | MB | Midbrain | 2.15 | |
| 2.94 | | |||
| Tdo2 | MY | Medulla | 1.53 | |
| 2.1 | | |||
| Tdo2 | OLF | Olfactory bulb | 2.16 | |
| 2.2 | | |||
| Tdo2 | P | Pons | 0.65 | |
| 0.74 | | |||
| Tdo2 | PAL | Pallidum | 0.44 | |
| 0.41 | | |||
| Tdo2 | RHP | Retrohippocampal region | 1.68 | |
| 1.5 | | |||
| Tdo2 | sAMY | Striatum-like amygdalar nuclei | 0.56 | |
| 0.6 | | |||
| Tdo2 | STR | Striatum | 0.63 | |
| 0.62 | | |||
| Tdo2 | STRd | Striatum dorsal region | 0.67 | |
| 0.64 | | |||
| Tdo2 | STRv | Striatum ventral region | 0.5 | |
| 0.58 | | |||
| Tdo2 | TH | Thalamus | 0.84 | |
| 1.31 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| T23O_HUMAN_326 | 9 | 326 | 334 | YNHVCMVHR | PRIDE |