AutismKB 2.0

Annotation Detail for TEC


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Basic Information Top
Gene Symbol:TEC ( MGC126760,MGC126762,PSCTK4 )
Gene Full Name: tec protein tyrosine kinase
Band: 4p12-p11
Quick LinksEntrez ID:7006; OMIM: 600583; Uniprot ID:TEC_HUMAN; ENSEMBL ID: ENSG00000135605; HGNC ID: 11719
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult11 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal11 / 33603073
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow3 / 4880161
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine2 / 2344728
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph1 / 4427022
lymph node2 / 9161021
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206301_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.45
Adipocyte4.25
AdrenalCortex4.55
Adrenalgland3.6
Amygdala4.5
Appendix4.35
AtrioventricularNode3.3
BDCA4+_DentriticCells4.55
Bonemarrow4.3
BronchialEpithelialCells4.2
CD105+_Endothelial4.25
CD14+_Monocytes4.55
CD19+_BCells(neg._sel.)4.6
CD33+_Myeloid5.45
CD34+5.4
CD4+_Tcells4.6
CD56+_NKCells5
CD71+_EarlyErythroid4
CD8+_Tcells4.05
CardiacMyocytes5.4
Caudatenucleus3.8
Cerebellum3.45
CerebellumPeduncles4.8
CiliaryGanglion3
CingulateCortex4.35
Colorectaladenocarcinoma4.3
DorsalRootGanglion3.35
FetalThyroid4.15
Fetalbrain4.25
Fetalliver3.7
Fetallung3.6
GlobusPallidus3.1
Heart5.45
Hypothalamus4.65
Kidney3.5
Leukemia_chronicMyelogenousK-5623.85
Leukemia_promyelocytic-HL-603.8
Leukemialymphoblastic(MOLT-4)3.4
Liver10.9
Lung4.75
Lymphnode3.65
Lymphoma_burkitts(Daudi)5.45
Lymphoma_burkitts(Raji)6.1
MedullaOblongata3.9
OccipitalLobe3.8
OlfactoryBulb3.3
Ovary2.85
Pancreas3.45
PancreaticIslet4.6
ParietalLobe4.5
Pituitary5
Placenta4.4
Pons4.1
PrefrontalCortex5.3
Prostate5
Salivarygland3.45
SkeletalMuscle5.05
Skin3.35
SmoothMuscle4.8
Spinalcord4.55
SubthalamicNucleus3.9
SuperiorCervicalGanglion5
TemporalLobe3.9
Testis3.7
TestisGermCell3.6
TestisIntersitial3.6
TestisLeydigCell4.2
TestisSeminiferousTubule3.65
Thalamus4.3
Thymus3.4
Thyroid5.35
Tongue4.25
Tonsil4.15
Trachea3.6
TrigeminalGanglion4.3
Uterus3.5
UterusCorpus3.85
WholeBlood4.75
Wholebrain3.65
colon4.3
pineal_day5.28
pineal_night5.16
retina5.15
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P213114
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.19 ± 1.06
Basal Forebrain2.2 ± 0.53
Basal Part of Pons1.65 ± 0.24
Cerebellar Cortex1.68 ± 0.74
Cerebellar Nuclei2.12 ± 0.62
Claustrum2.68 ± 0.85
Epithalamus1.5 ± 0.8
Frontal Lobe1.84 ± 0.73
Globus Pallidus2.48 ± 0.48
Hypothalamus1.79 ± 0.64
Insula1.76 ± 0.61
Limbic Lobe1.74 ± 0.62
Mesencephalon2.01 ± 0.71
Myelencephalon1.9 ± 0.69
Occipital Lobe1.99 ± 0.73
Parietal Lobe1.79 ± 0.6
Pontine Tegmentum1.85 ± 0.65
Striatum1.91 ± 0.49
Subthalamus2.19 ± 0.42
Temporal Lobe1.73 ± 0.67
Thalamus1.98 ± 0.62
White Matter2.19 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TecCBCerebellum0.41
1.08
TecCTXCerebral cortex0.94
1.54
TecHIPHippocampal region0.07
0.14
TecHPFHippocampal formation0.1
0.21
TecHYHypothalamus0.09
0.28
TecLSXLateral septal complex0
0
TecMBMidbrain0.49
1.48
TecMYMedulla0.21
0.6
TecOLFOlfactory bulb0.85
2.38
TecPPons0.1
0.23
TecPALPallidum0.06
0.05
TecRHPRetrohippocampal region0.14
0.28
TecsAMYStriatum-like amygdalar nuclei0
0
TecSTRStriatum0.04
0.06
TecSTRdStriatum dorsal region0.04
0.06
TecSTRvStriatum ventral region0.05
0.09
TecTHThalamus0.16
0.23
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069183 14 318 331 HAFGSIPEIIEYHK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018