AutismKB 2.0

Annotation Detail for TFAP2C


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Basic Information Top
Gene Symbol:TFAP2C ( AP2-GAMMA,ERF1,TFAP2G,hAP-2g )
Gene Full Name: transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Band: 20q13.31
Quick LinksEntrez ID:7022; OMIM: 601602; Uniprot ID:AP2C_HUMAN; ENSEMBL ID: ENSG00000087510; HGNC ID: 11744
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult32 / 193912116
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal29 / 33603078
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye1 / 2110544
heart2 / 8962622
intestine1 / 2344724
kidney0 / 2117770 
larynx1 / 2414541
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary5 / 10205148
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta10 / 28082535
prostate4 / 18934521
salivary gland1 / 2015549
skin5 / 21057423
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205286_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.7
Adipocyte9.05
AdrenalCortex9.75
Adrenalgland11
Amygdala9.9
Appendix9.35
AtrioventricularNode9.9
BDCA4+_DentriticCells9.85
Bonemarrow9.9
BronchialEpithelialCells19.55
CD105+_Endothelial8.95
CD14+_Monocytes10.15
CD19+_BCells(neg._sel.)10.1
CD33+_Myeloid11.7
CD34+11.75
CD4+_Tcells9.95
CD56+_NKCells10.85
CD71+_EarlyErythroid8.8
CD8+_Tcells7.4
CardiacMyocytes12.75
Caudatenucleus8.4
Cerebellum7.7
CerebellumPeduncles10.8
CiliaryGanglion12.6
CingulateCortex9.85
Colorectaladenocarcinoma15.8
DorsalRootGanglion9.35
FetalThyroid10.25
Fetalbrain9.2
Fetalliver8.1
Fetallung7.65
GlobusPallidus7.35
Heart18.15
Hypothalamus9.3
Kidney8.95
Leukemia_chronicMyelogenousK-5628.55
Leukemia_promyelocytic-HL-608.25
Leukemialymphoblastic(MOLT-4)29.75
Liver14.85
Lung10.6
Lymphnode7.9
Lymphoma_burkitts(Daudi)12
Lymphoma_burkitts(Raji)14.05
MedullaOblongata8.65
OccipitalLobe8.3
OlfactoryBulb7.45
Ovary6.55
Pancreas7.8
PancreaticIslet10.65
ParietalLobe9.85
Pituitary11.1
Placenta188.8
Pons8.9
PrefrontalCortex11
Prostate22.55
Salivarygland15.9
SkeletalMuscle15.8
Skin37.65
SmoothMuscle10.3
Spinalcord10.05
SubthalamicNucleus8.55
SuperiorCervicalGanglion16.45
TemporalLobe8.6
Testis8.1
TestisGermCell7.9
TestisIntersitial7.75
TestisLeydigCell10.1
TestisSeminiferousTubule8.05
Thalamus9.5
Thymus7.45
Thyroid12
Tongue28.5
Tonsil9.5
Trachea19.15
TrigeminalGanglion9.2
Uterus8.15
UterusCorpus12
WholeBlood10.4
Wholebrain8
colon9.2
pineal_day11.1
pineal_night10.52
retina11.175
small_intestine8.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P120472
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.92 ± 0.78
Basal Forebrain2.86 ± 0.33
Basal Part of Pons3.51 ± 0.66
Cerebellar Cortex3.4 ± 0.69
Cerebellar Nuclei3.49 ± 0.45
Claustrum3.5 ± 0.8
Epithalamus2.64 ± 0.8
Frontal Lobe3.39 ± 0.77
Globus Pallidus2.85 ± 0.91
Hypothalamus3.15 ± 0.64
Insula3.32 ± 0.78
Limbic Lobe3.53 ± 0.57
Mesencephalon3.49 ± 0.79
Myelencephalon3.38 ± 0.66
Occipital Lobe3.58 ± 0.44
Parietal Lobe3.41 ± 0.71
Pontine Tegmentum3.19 ± 0.72
Striatum3.32 ± 0.76
Subthalamus3.62 ± 1.45
Temporal Lobe3.31 ± 0.71
Thalamus3.24 ± 0.63
White Matter2.98 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tcfap2cCBCerebellum4.53
6.2
Tcfap2cCTXCerebral cortex16.55
12.11
Tcfap2cHIPHippocampal region8.07
8.17
Tcfap2cHPFHippocampal formation8.79
7.99
Tcfap2cHYHypothalamus3.87
3.1
Tcfap2cLSXLateral septal complex5.68
3.7
Tcfap2cMBMidbrain8
8.06
Tcfap2cMYMedulla4.73
7.47
Tcfap2cOLFOlfactory bulb14.64
12.12
Tcfap2cPPons6
7.92
Tcfap2cPALPallidum9.48
8.02
Tcfap2cRHPRetrohippocampal region10.09
7.71
Tcfap2csAMYStriatum-like amygdalar nuclei18.08
12.24
Tcfap2cSTRStriatum8.11
5.58
Tcfap2cSTRdStriatum dorsal region6.8
4.76
Tcfap2cSTRvStriatum ventral region7.89
5.29
Tcfap2cTHThalamus9.67
7.52
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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