AutismKB 2.0

Annotation Detail for NR2F1


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Basic Information Top
Gene Symbol:NR2F1 ( COUP-TFI,EAR-3,EAR3,ERBAL3,NR2F2,SVP44,TCFCOUP1,TFCOUP1 )
Gene Full Name: nuclear receptor subfamily 2, group F, member 1
Band: 5q15
Quick LinksEntrez ID:7025; OMIM: 132890; Uniprot ID:COT1_HUMAN; ENSEMBL ID: ENSG00000175745; HGNC ID: 7975
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus41 / 56401272
neonate1 / 3109732
infant1 / 2362042
juvenile1 / 5555617
adult61 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor3 / 26384511
glioma11 / 106883102
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal131 / 336030738
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain59 / 110098953
cervix3 / 4817162
connective tissue0 / 1492550 
ear20 / 162121233
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye12 / 21105456
heart0 / 896260 
intestine4 / 23447217
kidney5 / 21177723
larynx0 / 241450 
liver0 / 2077430 
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth1 / 6705214
muscle3 / 10771527
nerve2 / 15768126
ovary2 / 10205119
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach3 / 9661931
testis10 / 33044230
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus15 / 23287864
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209505_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.65
Adipocyte32.4
AdrenalCortex48.35
Adrenalgland40.75
Amygdala412.05
Appendix27.35
AtrioventricularNode39.4
BDCA4+_DentriticCells8.15
Bonemarrow11.9
BronchialEpithelialCells8.25
CD105+_Endothelial27.05
CD14+_Monocytes9.7
CD19+_BCells(neg._sel.)15.3
CD33+_Myeloid10.25
CD34+12.9
CD4+_Tcells11.9
CD56+_NKCells13.55
CD71+_EarlyErythroid13.6
CD8+_Tcells7.15
CardiacMyocytes184.7
Caudatenucleus19.5
Cerebellum138.05
CerebellumPeduncles75.3
CiliaryGanglion39.5
CingulateCortex130.1
Colorectaladenocarcinoma33.7
DorsalRootGanglion26.8
FetalThyroid21.2
Fetalbrain683.55
Fetalliver19.8
Fetallung226.55
GlobusPallidus39.45
Heart42.6
Hypothalamus146.65
Kidney28.45
Leukemia_chronicMyelogenousK-5628.15
Leukemia_promyelocytic-HL-607.5
Leukemialymphoblastic(MOLT-4)8.75
Liver32.5
Lung109.6
Lymphnode38.35
Lymphoma_burkitts(Daudi)12.75
Lymphoma_burkitts(Raji)28.6
MedullaOblongata46.55
OccipitalLobe85.35
OlfactoryBulb250.85
Ovary34.7
Pancreas15.4
PancreaticIslet23.15
ParietalLobe52.2
Pituitary24.75
Placenta308.85
Pons24.7
PrefrontalCortex219.95
Prostate113.9
Salivarygland17.85
SkeletalMuscle25.15
Skin22.45
SmoothMuscle24.95
Spinalcord161.9
SubthalamicNucleus62.45
SuperiorCervicalGanglion34.35
TemporalLobe68.25
Testis10.45
TestisGermCell15.75
TestisIntersitial17.35
TestisLeydigCell14.25
TestisSeminiferousTubule11.25
Thalamus100.55
Thymus8.2
Thyroid33.35
Tongue36.5
Tonsil16.75
Trachea15.55
TrigeminalGanglion31.3
Uterus207.05
UterusCorpus49.25
WholeBlood9.95
Wholebrain272.55
colon24
pineal_day48.48
pineal_night54.84
retina442.225
small_intestine27.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1339_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.06 ± 0.56
Basal Forebrain4.14 ± 0.52
Basal Part of Pons4 ± 0.42
Cerebellar Cortex4.74 ± 0.41
Cerebellar Nuclei4.23 ± 0.41
Claustrum5.39 ± 0.57
Epithalamus4.69 ± 0.5
Frontal Lobe4.34 ± 0.45
Globus Pallidus4.43 ± 0.59
Hypothalamus4.23 ± 0.54
Insula4.76 ± 0.3
Limbic Lobe4.48 ± 0.6
Mesencephalon4.51 ± 0.53
Myelencephalon4.58 ± 0.66
Occipital Lobe5.18 ± 0.7
Parietal Lobe4.42 ± 0.45
Pontine Tegmentum4.62 ± 0.6
Striatum3.71 ± 0.73
Subthalamus3.63 ± 1.04
Temporal Lobe4.76 ± 0.45
Thalamus4.78 ± 0.52
White Matter3.22 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nr2f1CBCerebellum61
59.15
Nr2f1CTXCerebral cortex100
94.04
Nr2f1HIPHippocampal region77.84
85.93
Nr2f1HPFHippocampal formation78.12
77.38
Nr2f1HYHypothalamus49.4
39.98
Nr2f1LSXLateral septal complex9.38
7.12
Nr2f1MBMidbrain30.27
28.43
Nr2f1MYMedulla30.87
28.13
Nr2f1OLFOlfactory bulb100
100
Nr2f1PPons35.26
31.77
Nr2f1PALPallidum33.16
30.32
Nr2f1RHPRetrohippocampal region74.75
62.98
Nr2f1sAMYStriatum-like amygdalar nuclei100
100
Nr2f1STRStriatum22.21
21.93
Nr2f1STRdStriatum dorsal region9.93
10.23
Nr2f1STRvStriatum ventral region17.55
11.95
Nr2f1THThalamus99.06
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00029964 22 71 92 GQGPPGSGQSQQHIECVVCGDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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