AutismKB 2.0

Annotation Detail for TFR2


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Basic Information Top
Gene Symbol:TFR2 ( HFE3,MGC126368,TFRC2 )
Gene Full Name: transferrin receptor 2
Band: 7q22.1
Quick LinksEntrez ID:7036; OMIM: 604720; Uniprot ID:TFR2_HUMAN; ENSEMBL ID: ENSG00000106327; HGNC ID: 11762
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult32 / 193912116
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor5 / 9635951
lung tumor0 / 1031270 
lymphoma5 / 7175569
non-neoplasia0 / 972500 
normal43 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow1 / 4880120
brain6 / 11009895
cervix3 / 4817162
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver15 / 20774372
lung1 / 3369742
lymph0 / 442700 
lymph node3 / 9161032
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207883_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8
Adipocyte6.55
AdrenalCortex7.6
Adrenalgland5.55
Amygdala6.65
Appendix7.05
AtrioventricularNode5.9
BDCA4+_DentriticCells7
Bonemarrow7.2
BronchialEpithelialCells6.25
CD105+_Endothelial13.25
CD14+_Monocytes7
CD19+_BCells(neg._sel.)6.9
CD33+_Myeloid8.15
CD34+12.7
CD4+_Tcells6.8
CD56+_NKCells7.65
CD71+_EarlyErythroid99.45
CD8+_Tcells6.2
CardiacMyocytes8.25
Caudatenucleus5.9
Cerebellum5.35
CerebellumPeduncles7.8
CiliaryGanglion6.95
CingulateCortex6.8
Colorectaladenocarcinoma6.5
DorsalRootGanglion5.55
FetalThyroid6.5
Fetalbrain6.5
Fetalliver31.55
Fetallung5.35
GlobusPallidus5.1
Heart8.85
Hypothalamus6.85
Kidney5.55
Leukemia_chronicMyelogenousK-5625.95
Leukemia_promyelocytic-HL-605.85
Leukemialymphoblastic(MOLT-4)5
Liver254.4
Lung7.15
Lymphnode5.65
Lymphoma_burkitts(Daudi)8.7
Lymphoma_burkitts(Raji)9.4
MedullaOblongata5.95
OccipitalLobe5.85
OlfactoryBulb5.2
Ovary4.45
Pancreas5.3
PancreaticIslet7
ParietalLobe7.2
Pituitary7.8
Placenta6.7
Pons6.55
PrefrontalCortex7.9
Prostate7.45
Salivarygland5.45
SkeletalMuscle8.75
Skin5.6
SmoothMuscle7.4
Spinalcord7.05
SubthalamicNucleus6.3
SuperiorCervicalGanglion9
TemporalLobe6.3
Testis5.6
TestisGermCell5.35
TestisIntersitial5.5
TestisLeydigCell6.55
TestisSeminiferousTubule5.65
Thalamus6.9
Thymus5.05
Thyroid7.85
Tongue7.2
Tonsil6.5
Trachea5.5
TrigeminalGanglion7.85
Uterus5.25
UterusCorpus6.05
WholeBlood7.1
Wholebrain5.15
colon6.55
pineal_day8.04
pineal_night8.02
retina8
small_intestine6.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14038_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.3 ± 1.1
Basal Forebrain2.01 ± 0.53
Basal Part of Pons1.53 ± 0.38
Cerebellar Cortex1.77 ± 0.84
Cerebellar Nuclei2.14 ± 0.75
Claustrum2.66 ± 0.77
Epithalamus1.55 ± 0.78
Frontal Lobe1.69 ± 0.7
Globus Pallidus2.31 ± 0.36
Hypothalamus1.97 ± 0.7
Insula1.71 ± 0.71
Limbic Lobe1.77 ± 0.6
Mesencephalon2.06 ± 0.71
Myelencephalon1.9 ± 0.68
Occipital Lobe1.83 ± 0.56
Parietal Lobe1.85 ± 0.69
Pontine Tegmentum1.92 ± 0.69
Striatum1.87 ± 0.67
Subthalamus2.02 ± 0.73
Temporal Lobe1.95 ± 0.75
Thalamus1.81 ± 0.58
White Matter2.19 ± 0.11
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018