AutismKB 2.0

Annotation Detail for TGM2


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Basic Information Top
Gene Symbol:TGM2 ( G-ALPHA-h,GNAH,TG2,TGC )
Gene Full Name: transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Band: 20q11.23
Quick LinksEntrez ID:7052; OMIM: 190196; Uniprot ID:TGM2_HUMAN; ENSEMBL ID: ENSG00000198959; HGNC ID: 11778
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body21 / 70761296
blastocyst2 / 6231932
fetus91 / 564012161
neonate160 / 310975145
infant0 / 236200 
juvenile13 / 55556233
adult1281 / 1939121660
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma21 / 82823253
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor29 / 119369242
germ cell tumor3 / 26384511
glioma139 / 1068831300
head and neck tumor20 / 136302146
kidney tumor18 / 68959261
leukemia12 / 95842125
liver tumor86 / 96359892
lung tumor13 / 103127126
lymphoma0 / 717550 
non-neoplasia29 / 97250298
normal2142 / 3360307637
ovarian tumor2 / 7668226
pancreatic tumor54 / 104616516
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer44 / 102680428
retinoblastoma0 / 463560 
skin tumor10 / 12494980
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor32 / 90257354
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland1 / 3319730
ascites0 / 400150 
bladder7 / 29757235
blood5 / 12347840
bone4 / 7165555
bone marrow15 / 48801307
brain412 / 1100989374
cervix7 / 48171145
connective tissue35 / 149255234
ear0 / 162120 
embryonic tissue26 / 215722120
esophagus1 / 2020949
eye51 / 211054241
heart15 / 89626167
intestine25 / 234472106
kidney155 / 211777731
larynx0 / 241450 
liver101 / 207743486
lung290 / 336974860
lymph0 / 442700 
lymph node10 / 91610109
mammary gland8 / 15327152
mouth16 / 67052238
muscle22 / 107715204
nerve1 / 1576863
ovary6 / 10205158
pancreas61 / 214812283
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta1054 / 2808253753
prostate55 / 189345290
salivary gland0 / 201550 
skin21 / 21057499
spleen12 / 53952222
stomach23 / 96619238
testis23 / 33044269
thymus39 / 81131480
thyroid7 / 47473147
tonsil0 / 169990 
trachea87 / 524131659
umbilical cord194 / 1368014181
uterus438 / 2328781880
vascular20 / 51780386
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201042_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.95
Adipocyte10.7
AdrenalCortex9
Adrenalgland31.95
Amygdala7.75
Appendix8.8
AtrioventricularNode5.65
BDCA4+_DentriticCells6.25
Bonemarrow12.5
BronchialEpithelialCells10.4
CD105+_Endothelial28.55
CD14+_Monocytes6.75
CD19+_BCells(neg._sel.)6.15
CD33+_Myeloid8.2
CD34+8.85
CD4+_Tcells6.5
CD56+_NKCells6.85
CD71+_EarlyErythroid125.95
CD8+_Tcells5.55
CardiacMyocytes26.8
Caudatenucleus7.55
Cerebellum5.6
CerebellumPeduncles8.15
CiliaryGanglion9.1
CingulateCortex7.4
Colorectaladenocarcinoma2078.65
DorsalRootGanglion5.5
FetalThyroid7.05
Fetalbrain6.5
Fetalliver56.65
Fetallung220.85
GlobusPallidus5.2
Heart189.6
Hypothalamus8.7
Kidney8.95
Leukemia_chronicMyelogenousK-56215.85
Leukemia_promyelocytic-HL-605.65
Leukemialymphoblastic(MOLT-4)5.65
Liver153.7
Lung619.8
Lymphnode15.85
Lymphoma_burkitts(Daudi)8.55
Lymphoma_burkitts(Raji)9.25
MedullaOblongata6.2
OccipitalLobe6.55
OlfactoryBulb7.7
Ovary71.45
Pancreas5.8
PancreaticIslet294.65
ParietalLobe7.35
Pituitary15.1
Placenta2411.8
Pons6.85
PrefrontalCortex15.2
Prostate27.8
Salivarygland5.7
SkeletalMuscle14.75
Skin5.35
SmoothMuscle24.65
Spinalcord13.45
SubthalamicNucleus7.1
SuperiorCervicalGanglion7.95
TemporalLobe6.45
Testis5.65
TestisGermCell5.3
TestisIntersitial5.5
TestisLeydigCell6.75
TestisSeminiferousTubule6.7
Thalamus9.8
Thymus7.5
Thyroid9.05
Tongue6.35
Tonsil6.8
Trachea18.45
TrigeminalGanglion7.15
Uterus114.45
UterusCorpus15.65
WholeBlood6.45
Wholebrain5.7
colon7.4
pineal_day7.88
pineal_night8.3
retina624.875
small_intestine22.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13507_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.91 ± 0.96
Basal Forebrain2.53 ± 0.41
Basal Part of Pons2.36 ± 0.49
Cerebellar Cortex2.26 ± 0.53
Cerebellar Nuclei3.03 ± 0.55
Claustrum3.12 ± 0.77
Epithalamus2.51 ± 0.93
Frontal Lobe2.63 ± 0.76
Globus Pallidus4.5 ± 0.33
Hypothalamus2.7 ± 0.89
Insula2.44 ± 0.81
Limbic Lobe2.67 ± 0.81
Mesencephalon2.88 ± 0.83
Myelencephalon2.76 ± 0.73
Occipital Lobe2.83 ± 0.7
Parietal Lobe2.75 ± 0.78
Pontine Tegmentum2.83 ± 0.75
Striatum3.4 ± 0.75
Subthalamus3.14 ± 0.36
Temporal Lobe2.58 ± 0.74
Thalamus2.81 ± 0.65
White Matter4.02 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tgm2CBCerebellum7.86
11.11
Tgm2CTXCerebral cortex4.41
3.99
Tgm2HIPHippocampal region5.84
6.72
Tgm2HPFHippocampal formation5.41
5.91
Tgm2HYHypothalamus2.1
2.49
Tgm2LSXLateral septal complex2.48
2.64
Tgm2MBMidbrain3.97
6.08
Tgm2MYMedulla5.93
7.58
Tgm2OLFOlfactory bulb4.45
3.67
Tgm2PPons3.21
4.68
Tgm2PALPallidum4.41
5.43
Tgm2RHPRetrohippocampal region4.72
4.62
Tgm2sAMYStriatum-like amygdalar nuclei4.95
4.96
Tgm2STRStriatum3.03
3.16
Tgm2STRdStriatum dorsal region2.43
2.77
Tgm2STRvStriatum ventral region3.87
3.3
Tgm2THThalamus6.32
6.98
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009044 12 551 562 YRDCLTESNLIK Peptide Atlas
TGM2_HUMAN_0 0 0 0 ALLVEPVINSYLLAER PRIDE
TGM2_HUMAN_0 0 0 0 YLLNLNLEPFSEK PRIDE
TGM2_HUMAN_2 8 2 9 AEELVLER PRIDE
TGM2_HUMAN_234 7 234 240 QGVLLGR PRIDE
TGM2_HUMAN_364 13 364 376 SEGTYCCGPVPVR PRIDE
TGM2_HUMAN_464 12 464 475 LAEKEETGMAMR PRIDE
TGM2_HUMAN_465 12 465 476 LAEKEETGMAMR PRIDE
TGM2_HUMAN_527 13 527 539 YLLNLNLEPFSEK PRIDE
TGM2_HUMAN_564 16 564 579 ALLVEPVINSYLLAER PRIDE
TGM2_HUMAN_580 10 580 589 DLYLENPEIK PRIDE
TGM2_HUMAN_652 12 652 663 MDLLPLHMGLHK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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