AutismKB 2.0

Annotation Detail for TGM3


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Basic Information Top
Gene Symbol:TGM3 ( MGC126249,MGC126250,TGE )
Gene Full Name: transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Band: 20p13
Quick LinksEntrez ID:7053; OMIM: 600238; Uniprot ID:TGM3_HUMAN; ENSEMBL ID: ENSG00000125780; HGNC ID: 11779
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult29 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor8 / 17290462
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor26 / 136302190
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal65 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain5 / 11009894
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus16 / 20209791
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx2 / 2414582
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth56 / 67052835
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx19 / 41328459
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206004_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.8
Adipocyte5.4
AdrenalCortex5.75
Adrenalgland4.6
Amygdala5.9
Appendix5.55
AtrioventricularNode5.6
BDCA4+_DentriticCells6
Bonemarrow5.4
BronchialEpithelialCells5.45
CD105+_Endothelial5.6
CD14+_Monocytes5.8
CD19+_BCells(neg._sel.)5.95
CD33+_Myeloid7.15
CD34+6.95
CD4+_Tcells6.05
CD56+_NKCells6.15
CD71+_EarlyErythroid5.15
CD8+_Tcells4.9
CardiacMyocytes7.05
Caudatenucleus5
Cerebellum6.65
CerebellumPeduncles7
CiliaryGanglion3.85
CingulateCortex8.6
Colorectaladenocarcinoma5.55
DorsalRootGanglion4.25
FetalThyroid5.35
Fetalbrain5.75
Fetalliver4.75
Fetallung4.6
GlobusPallidus4.05
Heart7.15
Hypothalamus6.05
Kidney4.45
Leukemia_chronicMyelogenousK-5626.2
Leukemia_promyelocytic-HL-604.85
Leukemialymphoblastic(MOLT-4)4.4
Liver7.3
Lung6.05
Lymphnode4.75
Lymphoma_burkitts(Daudi)7.05
Lymphoma_burkitts(Raji)7.7
MedullaOblongata5
OccipitalLobe4.95
OlfactoryBulb4.55
Ovary3.65
Pancreas4.4
PancreaticIslet5.9
ParietalLobe5.8
Pituitary6.45
Placenta5.75
Pons5.2
PrefrontalCortex6.8
Prostate6.55
Salivarygland4.4
SkeletalMuscle23.1
Skin9
SmoothMuscle6.3
Spinalcord6.35
SubthalamicNucleus5.05
SuperiorCervicalGanglion17.4
TemporalLobe5
Testis4.75
TestisGermCell4.55
TestisIntersitial4.65
TestisLeydigCell5.4
TestisSeminiferousTubule5.35
Thalamus5.6
Thymus4.4
Thyroid6.95
Tongue437.6
Tonsil63.7
Trachea4.7
TrigeminalGanglion8.35
Uterus5.45
UterusCorpus10.1
WholeBlood7.15
Wholebrain4.6
colon5.55
pineal_day6.84
pineal_night6.64
retina6.7
small_intestine5.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15510_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.45 ± 0.89
Basal Forebrain1.79 ± 0.19
Basal Part of Pons1.56 ± 0.33
Cerebellar Cortex1.74 ± 0.81
Cerebellar Nuclei2.13 ± 0.78
Claustrum2.82 ± 0.87
Epithalamus1.97 ± 1.07
Frontal Lobe1.8 ± 0.73
Globus Pallidus2.36 ± 0.39
Hypothalamus1.9 ± 0.73
Insula2.08 ± 0.7
Limbic Lobe2.02 ± 0.63
Mesencephalon2.01 ± 0.73
Myelencephalon1.95 ± 0.7
Occipital Lobe2.01 ± 0.65
Parietal Lobe1.9 ± 0.67
Pontine Tegmentum2.03 ± 0.76
Striatum2.03 ± 0.64
Subthalamus2.03 ± 0.77
Temporal Lobe1.87 ± 0.67
Thalamus1.89 ± 0.7
White Matter2.07 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tgm3CBCerebellum1.6
1.78
Tgm3CTXCerebral cortex1.19
1.04
Tgm3HIPHippocampal region1.14
1.06
Tgm3HPFHippocampal formation0.89
0.88
Tgm3HYHypothalamus0.37
0.44
Tgm3LSXLateral septal complex0.09
0.63
Tgm3MBMidbrain0.67
0.91
Tgm3MYMedulla0.75
1.01
Tgm3OLFOlfactory bulb0.76
0.55
Tgm3PPons0.9
1.29
Tgm3PALPallidum0.21
0.2
Tgm3RHPRetrohippocampal region0.47
0.56
Tgm3sAMYStriatum-like amygdalar nuclei0.28
0.16
Tgm3STRStriatum0.13
0.13
Tgm3STRdStriatum dorsal region0.12
0.09
Tgm3STRvStriatum ventral region0.07
0.15
Tgm3THThalamus0.64
0.61
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00043830 18 589 606 DIILDNPTLTLEVLNEAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018