AutismKB 2.0

Annotation Detail for THBS1


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Basic Information Top
Gene Symbol:THBS1 ( THBS,THBS-1,TSP,TSP-1,TSP1 )
Gene Full Name: thrombospondin 1
Band: 15q14
Quick LinksEntrez ID:7057; OMIM: 188060; Uniprot ID:TSP1_HUMAN; ENSEMBL ID: ENSG00000137801; HGNC ID: 11785
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst29 / 62319465
fetus120 / 564012212
neonate14 / 31097450
infant0 / 236200 
juvenile5 / 5555689
adult365 / 1939121188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma4 / 17475228
breast (mammary gland) tumor31 / 94178329
cervical tumor1 / 3436629
chondrosarcoma20 / 82823241
colorectal tumor32 / 114246280
esophageal tumor52 / 172903007
gastrointestinal tumor16 / 119369134
germ cell tumor3 / 26384511
glioma14 / 106883130
head and neck tumor29 / 136302212
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor38 / 96359394
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia16 / 97250164
normal612 / 3360307182
ovarian tumor16 / 76682208
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland3 / 3319790
ascites0 / 400150 
bladder6 / 29757201
blood8 / 12347864
bone56 / 71655781
bone marrow13 / 48801266
brain54 / 110098949
cervix1 / 4817120
connective tissue32 / 149255214
ear2 / 16212123
embryonic tissue44 / 215722203
esophagus52 / 202092573
eye11 / 21105452
heart5 / 8962655
intestine50 / 234472213
kidney60 / 211777283
larynx5 / 24145207
liver57 / 207743274
lung96 / 336974284
lymph0 / 442700 
lymph node0 / 916100 
mammary gland81 / 153271528
mouth10 / 67052149
muscle21 / 107715194
nerve5 / 15768317
ovary18 / 102051176
pancreas23 / 214812107
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta31 / 280825110
prostate22 / 189345116
salivary gland2 / 2015599
skin60 / 210574284
spleen1 / 5395218
stomach22 / 96619227
testis4 / 33044212
thymus4 / 8113149
thyroid14 / 47473294
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord10 / 13680730
uterus41 / 232878176
vascular57 / 517801100
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201109_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.1
Adipocyte647.85
AdrenalCortex15.05
Adrenalgland7.8
Amygdala6.4
Appendix9.1
AtrioventricularNode8.35
BDCA4+_DentriticCells6.55
Bonemarrow14.8
BronchialEpithelialCells1288.65
CD105+_Endothelial6.6
CD14+_Monocytes11.8
CD19+_BCells(neg._sel.)6.75
CD33+_Myeloid8.6
CD34+7.85
CD4+_Tcells6.75
CD56+_NKCells7.8
CD71+_EarlyErythroid6.2
CD8+_Tcells5.7
CardiacMyocytes2277.05
Caudatenucleus5.7
Cerebellum5.25
CerebellumPeduncles7.5
CiliaryGanglion6.95
CingulateCortex6.7
Colorectaladenocarcinoma6.35
DorsalRootGanglion5.5
FetalThyroid7.1
Fetalbrain21.25
Fetalliver7.2
Fetallung537.05
GlobusPallidus4.95
Heart8.8
Hypothalamus6.6
Kidney11.8
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.75
Leukemialymphoblastic(MOLT-4)5
Liver8.95
Lung57.05
Lymphnode25.95
Lymphoma_burkitts(Daudi)8.35
Lymphoma_burkitts(Raji)9.5
MedullaOblongata5.7
OccipitalLobe5.65
OlfactoryBulb5.15
Ovary97.6
Pancreas10.95
PancreaticIslet9
ParietalLobe7.05
Pituitary7.6
Placenta282.5
Pons6.25
PrefrontalCortex7.45
Prostate7.65
Salivarygland10.55
SkeletalMuscle8.1
Skin6.15
SmoothMuscle1423.75
Spinalcord6.9
SubthalamicNucleus6
SuperiorCervicalGanglion8.7
TemporalLobe6.1
Testis5.55
TestisGermCell5.5
TestisIntersitial5.5
TestisLeydigCell6.6
TestisSeminiferousTubule5.65
Thalamus6.7
Thymus5.15
Thyroid8
Tongue7.3
Tonsil6.4
Trachea47.4
TrigeminalGanglion7.35
Uterus154.3
UterusCorpus24.75
WholeBlood7.45
Wholebrain5.05
colon30.05
pineal_day7.7
pineal_night7.6
retina7.975
small_intestine25.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P17182
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.27 ± 1.01
Basal Forebrain1.73 ± 0.63
Basal Part of Pons1.43 ± 0.39
Cerebellar Cortex1.91 ± 0.79
Cerebellar Nuclei1.94 ± 0.67
Claustrum2.26 ± 0.69
Epithalamus1.43 ± 0.68
Frontal Lobe1.68 ± 0.72
Globus Pallidus1.83 ± 0.49
Hypothalamus1.66 ± 0.59
Insula1.68 ± 0.43
Limbic Lobe1.91 ± 0.71
Mesencephalon1.87 ± 0.8
Myelencephalon1.78 ± 0.68
Occipital Lobe1.99 ± 0.77
Parietal Lobe1.86 ± 0.68
Pontine Tegmentum1.87 ± 0.71
Striatum1.63 ± 0.84
Subthalamus1.83 ± 0.74
Temporal Lobe1.7 ± 0.72
Thalamus1.67 ± 0.71
White Matter1.89 ± 0.57
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Thbs1CBCerebellum25.53
31.89
Thbs1CTXCerebral cortex19.84
14.28
Thbs1HIPHippocampal region14.98
15.77
Thbs1HPFHippocampal formation17.34
18.16
Thbs1HYHypothalamus13.02
10.24
Thbs1LSXLateral septal complex14
14.42
Thbs1MBMidbrain18.38
19.53
Thbs1MYMedulla20.43
20.94
Thbs1OLFOlfactory bulb37.49
31.44
Thbs1PPons19.5
22
Thbs1PALPallidum12.05
9.68
Thbs1RHPRetrohippocampal region21.2
21.36
Thbs1sAMYStriatum-like amygdalar nuclei16.3
11.14
Thbs1STRStriatum12.34
9.73
Thbs1STRdStriatum dorsal region7.08
6.21
Thbs1STRvStriatum ventral region30.27
19.54
Thbs1THThalamus10.5
9.35
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009604 13 663 675 CNYLGHYSDPMYR Peptide Atlas
TSP1_HUMAN_959 10 959 968 RFQMIPLDPK PRIDE
TSP1_HUMAN_960 9 960 968 FQMIPLDPK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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