AutismKB 2.0

Annotation Detail for THBS2


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Basic Information Top
Gene Symbol:THBS2 ( TSP2 )
Gene Full Name: thrombospondin 2
Band: 6q27
Quick LinksEntrez ID:7058; OMIM: 188061; Uniprot ID:TSP2_HUMAN; ENSEMBL ID: ENSG00000186340; HGNC ID: 11786
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst3 / 6231948
fetus57 / 564012101
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult109 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma6 / 17475343
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma21 / 82823253
colorectal tumor14 / 114246122
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor5 / 26384518
glioma2 / 10688318
head and neck tumor9 / 13630266
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal244 / 336030772
ovarian tumor0 / 766820 
pancreatic tumor28 / 104616267
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone34 / 71655474
bone marrow6 / 48801122
brain55 / 110098949
cervix0 / 481710 
connective tissue21 / 149255140
ear7 / 16212431
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye13 / 21105461
heart6 / 8962666
intestine17 / 23447272
kidney9 / 21177742
larynx2 / 2414582
liver2 / 2077439
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth7 / 67052104
muscle11 / 107715102
nerve3 / 15768190
ovary0 / 1020510 
pancreas31 / 214812144
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin26 / 210574123
spleen0 / 539520 
stomach4 / 9661941
testis12 / 33044236
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus19 / 23287881
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203083_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.4
Adipocyte280.95
AdrenalCortex17.2
Adrenalgland11.25
Amygdala25.7
Appendix132.5
AtrioventricularNode37.35
BDCA4+_DentriticCells7.2
Bonemarrow13.75
BronchialEpithelialCells11
CD105+_Endothelial7.5
CD14+_Monocytes5.9
CD19+_BCells(neg._sel.)9.45
CD33+_Myeloid13.5
CD34+10.8
CD4+_Tcells6.5
CD56+_NKCells8.4
CD71+_EarlyErythroid8.6
CD8+_Tcells7.35
CardiacMyocytes408.85
Caudatenucleus46.05
Cerebellum18.1
CerebellumPeduncles15.75
CiliaryGanglion15.85
CingulateCortex12.9
Colorectaladenocarcinoma7.05
DorsalRootGanglion11
FetalThyroid74
Fetalbrain11.55
Fetalliver12.65
Fetallung73.25
GlobusPallidus10.15
Heart14.5
Hypothalamus76
Kidney9.3
Leukemia_chronicMyelogenousK-56210.45
Leukemia_promyelocytic-HL-6010.2
Leukemialymphoblastic(MOLT-4)9.3
Liver15.1
Lung18.3
Lymphnode10.7
Lymphoma_burkitts(Daudi)18.35
Lymphoma_burkitts(Raji)13.25
MedullaOblongata48.8
OccipitalLobe32.25
OlfactoryBulb56.45
Ovary20.55
Pancreas21.55
PancreaticIslet13.75
ParietalLobe58
Pituitary63.9
Placenta11.7
Pons38.55
PrefrontalCortex25.25
Prostate13.4
Salivarygland16.7
SkeletalMuscle15.2
Skin98.3
SmoothMuscle1846.25
Spinalcord106.2
SubthalamicNucleus11.8
SuperiorCervicalGanglion14.7
TemporalLobe11.7
Testis11.15
TestisGermCell9.75
TestisIntersitial9.75
TestisLeydigCell11.95
TestisSeminiferousTubule12.9
Thalamus54.1
Thymus9.1
Thyroid20.85
Tongue23.7
Tonsil11.4
Trachea21.3
TrigeminalGanglion23.9
Uterus162.2
UterusCorpus643.05
WholeBlood8.65
Wholebrain24.35
colon42.4
pineal_day14.48
pineal_night12.94
retina55.45
small_intestine23.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_652_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.27 ± 0.62
Basal Forebrain4.83 ± 0.56
Basal Part of Pons4.8 ± 0.66
Cerebellar Cortex4.04 ± 0.45
Cerebellar Nuclei5.59 ± 0.74
Claustrum4.16 ± 0.7
Epithalamus4.98 ± 0.42
Frontal Lobe4.44 ± 0.76
Globus Pallidus6.33 ± 0.47
Hypothalamus4.73 ± 0.7
Insula4.09 ± 0.43
Limbic Lobe4.26 ± 0.86
Mesencephalon4.66 ± 0.76
Myelencephalon4.74 ± 0.66
Occipital Lobe4.72 ± 0.81
Parietal Lobe4.48 ± 0.73
Pontine Tegmentum4.73 ± 0.72
Striatum5.42 ± 0.69
Subthalamus4.34 ± 0.68
Temporal Lobe4.34 ± 0.73
Thalamus4.99 ± 0.47
White Matter6.9 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Thbs2CBCerebellum2.04
3.46
Thbs2CTXCerebral cortex5.11
4.4
Thbs2HIPHippocampal region2.76
5.02
Thbs2HPFHippocampal formation2.49
4.34
Thbs2HYHypothalamus2.06
2.66
Thbs2LSXLateral septal complex0.43
0.49
Thbs2MBMidbrain0.84
1.81
Thbs2MYMedulla4.58
6.42
Thbs2OLFOlfactory bulb8.06
8.04
Thbs2PPons2.33
3.68
Thbs2PALPallidum1.04
1.01
Thbs2RHPRetrohippocampal region1.91
3.31
Thbs2sAMYStriatum-like amygdalar nuclei0.58
0.79
Thbs2STRStriatum0.83
0.89
Thbs2STRdStriatum dorsal region1.08
1.18
Thbs2STRvStriatum ventral region0.4
0.33
Thbs2THThalamus1.97
2.59
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00071489 22 224 245 KGCQQGQGAEINAISENTETLR Peptide Atlas
TSP2_HUMAN_541 6 541 546 QMCNKR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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