AutismKB 2.0

Annotation Detail for THRA


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Basic Information Top
Gene Symbol:THRA ( AR7,EAR7,ERB-T-1,ERBA,ERBA1,MGC000261,MGC43240,NR1A1,THRA1,THRA2,c-ERBA-1 )
Gene Full Name: thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
Band: 17q21.1
Quick LinksEntrez ID:7067; OMIM: 190120; Uniprot ID:THA_HUMAN; ENSEMBL ID: ENSG00000126351; HGNC ID: 11796
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus72 / 564012127
neonate0 / 310970 
infant3 / 23620127
juvenile2 / 5555635
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor7 / 26384526
glioma33 / 106883308
head and neck tumor13 / 13630295
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal210 / 336030762
ovarian tumor9 / 76682117
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder1 / 2975733
blood2 / 12347816
bone3 / 7165541
bone marrow0 / 488010 
brain163 / 1100989148
cervix3 / 4817162
connective tissue5 / 14925533
ear3 / 16212185
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye19 / 21105490
heart4 / 8962644
intestine16 / 23447268
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle9 / 10771583
nerve1 / 1576863
ovary9 / 10205188
pancreas7 / 21481232
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta4 / 28082514
prostate11 / 18934558
salivary gland12 / 20155595
skin4 / 21057418
spleen4 / 5395274
stomach2 / 9661920
testis12 / 33044236
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204100_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.7
Adipocyte6.35
AdrenalCortex7.05
Adrenalgland5.6
Amygdala40.55
Appendix6.5
AtrioventricularNode5.1
BDCA4+_DentriticCells5.85
Bonemarrow6.25
BronchialEpithelialCells6
CD105+_Endothelial6.3
CD14+_Monocytes6.35
CD19+_BCells(neg._sel.)6.3
CD33+_Myeloid8.1
CD34+8.05
CD4+_Tcells7
CD56+_NKCells7.4
CD71+_EarlyErythroid6.05
CD8+_Tcells6.25
CardiacMyocytes8.45
Caudatenucleus69.85
Cerebellum15.5
CerebellumPeduncles17.75
CiliaryGanglion4.5
CingulateCortex14.55
Colorectaladenocarcinoma6.35
DorsalRootGanglion4.85
FetalThyroid6.25
Fetalbrain35.5
Fetalliver5.25
Fetallung5.3
GlobusPallidus4.85
Heart8.3
Hypothalamus16.8
Kidney5.25
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.6
Leukemialymphoblastic(MOLT-4)4.9
Liver8.3
Lung6.95
Lymphnode5.5
Lymphoma_burkitts(Daudi)8.1
Lymphoma_burkitts(Raji)9.1
MedullaOblongata5.95
OccipitalLobe20
OlfactoryBulb9.65
Ovary4.45
Pancreas5.15
PancreaticIslet6.85
ParietalLobe7.25
Pituitary7.5
Placenta5.95
Pons6.85
PrefrontalCortex20.8
Prostate7.05
Salivarygland5.15
SkeletalMuscle7.3
Skin4.95
SmoothMuscle6.85
Spinalcord18.7
SubthalamicNucleus7.7
SuperiorCervicalGanglion7.35
TemporalLobe15.95
Testis5.5
TestisGermCell5.15
TestisIntersitial5.2
TestisLeydigCell6.35
TestisSeminiferousTubule5.55
Thalamus12.5
Thymus4.8
Thyroid8.15
Tongue6.05
Tonsil6.25
Trachea5.35
TrigeminalGanglion6.5
Uterus5.3
UterusCorpus5.6
WholeBlood6.05
Wholebrain33.8
colon6.45
pineal_day14.1
pineal_night9.7
retina9.4
small_intestine5.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P207742
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala13.03 ± 0.32
Basal Forebrain13.07 ± 0.32
Basal Part of Pons12.57 ± 0.23
Cerebellar Cortex12.7 ± 0.23
Cerebellar Nuclei12.38 ± 0.32
Claustrum12.76 ± 0.49
Epithalamus12.94 ± 0.23
Frontal Lobe12.79 ± 0.29
Globus Pallidus12.72 ± 0.23
Hypothalamus13.07 ± 0.29
Insula13.1 ± 0.3
Limbic Lobe12.77 ± 0.36
Mesencephalon12.64 ± 0.29
Myelencephalon12.73 ± 0.36
Occipital Lobe12.31 ± 0.36
Parietal Lobe12.66 ± 0.3
Pontine Tegmentum12.68 ± 0.32
Striatum12.88 ± 0.51
Subthalamus12.81 ± 0.07
Temporal Lobe12.92 ± 0.33
Thalamus12.38 ± 0.26
White Matter12.29 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ThraCBCerebellum100
70.01
ThraCTXCerebral cortex100
100
ThraHIPHippocampal region87.64
100
ThraHPFHippocampal formation100
100
ThraHYHypothalamus100
53.23
ThraLSXLateral septal complex93.19
53.34
ThraMBMidbrain95.24
60.62
ThraMYMedulla97.73
60.7
ThraOLFOlfactory bulb100
98.89
ThraPPons95.63
59.42
ThraPALPallidum92.64
57.02
ThraRHPRetrohippocampal region100
100
ThrasAMYStriatum-like amygdalar nuclei100
78.77
ThraSTRStriatum100
80.07
ThraSTRdStriatum dorsal region100
79.17
ThraSTRvStriatum ventral region100
94.61
ThraTHThalamus82.83
48.81
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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